Search Result
Results for "
L-Phenylmercapturic acid-d<sup>5</sup>
" in MedChemExpress (MCE) Product Catalog:
1296
Inhibitors & Agonists
1
Biochemical Assay Reagents
1249
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-143368S
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Isotope-Labeled Compounds
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Others
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L-Phenylmercapturic acid-d5is the deuterium labeledL-Phenylmercapturic acid(HY-143368) . L-Phenylmercapturic acid is often used as a biomarker for exposure to aniline compounds such as aniline and xylene .
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-
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- HY-15306S
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SB-497115-<sup>13sup>C4
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Thrombopoietin Receptor
Bacterial
Apoptosis
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Infection
Cardiovascular Disease
Cancer
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Eltrombopag- 13C4 (SB-497115- 13C4) is 13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells [5].
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- HY-108166
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Fluorescent Dye
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Inflammation/Immunology
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Hydroxystilbamidine, a dye capable of binding to both DNA and RNA, is a powerful inhibitor of cellular ribonucleases. Hydroxystilbamidine is a retrograde fluorescent tracer and a histochemical stain [1]sup .
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-
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- HY-145128
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-
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- HY-126906
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Antibiotic
P-glycoprotein
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Cancer
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Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity [1]sup>[2].
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-
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- HY-W011509
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Potassium Channel
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Neurological Disease
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CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels [1]sup .
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-
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- HY-N11122
-
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Others
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Others
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7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol is a cuminol glycoside. 7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol can be isolated from Rhodiola rosea sup>[1].
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- HY-161119
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Dynamin
Reactive Oxygen Species
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Cardiovascular Disease
Cancer
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Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer [1]sup .
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- HY-12741
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LDN-0212320; OSU-0212320
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EAAT
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Neurological Disease
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LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC [1]sup .
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-
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- HY-N8824
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Others
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Others
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Maackiaflavanone (compound 4) is a kind of prenylated flavanone. Maackia can be isolated from M. amurensi.
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-
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- HY-137048
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SARS-CoV
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Infection
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PF-00835231 is a CoV-2 cysteine 3C-like protease (3CL pro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CL pro, respectively. PF-00835231 is developed for the research of anti-SARS-CoV-2/COVID-19 [1]sup>[2].
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-
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- HY-N3872
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Others
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Others
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Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.
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-
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- HY-D1583
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DBCO-Cy5; Cyanine5 dibenzocyclooctyne
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Fluorescent Dye
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Others
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Cyanine5 DBCO (DBCO-Cy5) is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm) [2].
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- HY-N8859
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16-Hydroxyiridal
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Others
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Others
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Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against MCF-7 and C32 cell lines.
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- HY-156383
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PROTAC Linkers
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Cancer
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SCO-PEG3-NHS is a PEG linker with a terminal imine(NH) group. SCO-PEG3-NHS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
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- HY-D1327
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Fluorescent Dye
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Others
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Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λex=684 nm, λem=710 nm) [1]sup >. Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-N0733S2
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-
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- HY-B0271S1
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Pyrazinecarboxamide-<sup>13sup>C,<sup>15sup>N; Pyrazinoic acid amide-<sup>13sup>C,<sup>15sup>N
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Autophagy
Antibiotic
Bacterial
Isotope-Labeled Compounds
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Infection
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Pyrazinamide- 13C, 15N is 15N and 13C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
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- HY-N0650S6
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(-)-Serine-<sup>13sup>C,<sup>15sup>N; (S)-Serine-<sup>13sup>C,<sup>15sup>N
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Isotope-Labeled Compounds
Endogenous Metabolite
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Cancer
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L-Serine1- 13C, 15N is the 13C- and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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-
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- HY-A0061S
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Trifluorothymidine-<sup>13sup>C,<sup>15sup>N2; 5-Trifluorothymidine-<sup>13sup>C,<sup>15sup>N2; TFT-<sup>13sup>C,<sup>15sup>N2
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Thymidylate Synthase
Nucleoside Antimetabolite/Analog
HSV
Orthopoxvirus
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Cancer
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Trifluridine- 13C, 15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].
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- HY-Y0418S
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Dulcitol-<sup>13sup>C; Melampyrit-<sup>13sup>C; NSC 1944-<sup>13sup>C
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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Dulcite- 13C is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
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- HY-13458S1
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L-DOPS-<sup>13sup>C2,<sup>15sup>N hydrochloride; DOPS-<sup>13sup>C2,<sup>15sup>N hydrochloride; SM5688-<sup>13sup>C2,<sup>15sup>N hydrochloride
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Adrenergic Receptor
Isotope-Labeled Compounds
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Neurological Disease
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Droxidopa- 13C2, 15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier[1][2].
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-
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- HY-66005S4
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Paracetamol-<sup>13sup>C2,<sup>15sup>N; 4-Acetamidophenol-<sup>13sup>C2,<sup>15sup>N; 4'-Hydroxyacetanilide-<sup>13sup>C2,<sup>15sup>N
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COX
Bacterial
Histone Acetyltransferase
Parasite
Endogenous Metabolite
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Acetaminophen- 13C2, 15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].
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-
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- HY-15236S1
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RO 2433--d<sup>1sup>,<sup>13sup>C,<sup>15sup>N2; GS-331007--d<sup>1sup>,<sup>13sup>C,<sup>15sup>N2
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HCV
Isotope-Labeled Compounds
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Infection
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PSI-6206-d1, 13C, 15N2 is 15N and 13C labeled PSI-6206 (HY-15236). PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
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- HY-13613S2
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GG 745-<sup>13sup>C,<sup>15sup>N,d; GI 198745-<sup>13sup>C,<sup>15sup>N,d
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5 alpha Reductase
Apoptosis
Isotope-Labeled Compounds
|
Cancer
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Dutasteride- 13C, 15N,d is 15N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
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-
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- HY-B0389S10
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Glucose-<sup>13sup>C; D-(+)-Glucose-<sup>13sup>C; Dextrose-<sup>13sup>C
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Endogenous Metabolite
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Metabolic Disease
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D-Glucose- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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-
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- HY-B0389S29
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Glucose-<sup>18sup>O; D-(+)-Glucose-<sup>18sup>O; Dextrose-<sup>18sup>O
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Endogenous Metabolite
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Metabolic Disease
Cancer
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D-Glucose- 18O is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules
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-
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- HY-Y1250S6
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Fmoc glycine-<sup>13sup>C2,<sup>15sup>N; N-(9-Fluorenylmethoxycarbonyl)glycine-<sup>13sup>C2,<sup>15sup>N; N-Fluorenylmethoxycarbonylglycine-<sup>13sup>C2,<sup>15sup>N; NPC 14692-<sup>13sup>C2-<sup>15sup>N; NSC 334288-<sup>13sup>C2,<sup>15sup>N; [[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]acetic acid-<sup>13sup>C2,<sup>15sup>N
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Isotope-Labeled Compounds
Influenza Virus
Bacterial
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Infection
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Fmoc-Gly-OH- 13C2, 15N is a 15N-labeled and 13C-labled Crystal Violet. Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.
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-
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- HY-N1480S
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6-Desoxygalactose-<sup>13sup>C; L-(-)-Fucose-<sup>13sup>C; L-Galactomethylose-<sup>13sup>C
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Isotope-Labeled Compounds
Endogenous Metabolite
Parasite
|
Infection
Metabolic Disease
|
(-)-Fucose- 13C is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[1]
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-
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- HY-N8930
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Others
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Others
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Eupatorin-5-methyl ether (TMF) can be isolated from Orthosiphon stamineus. Eupatorin-5-methyl ether is a kind of flavonoid compound. Eupatorin-5-methyl ether inhibits NO production (IC50 5.5 μM).
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-
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- HY-128436
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HDAC
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Cancer
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KT-531 is a potent and selective inhibitor of HDAC6 with an IC50 of 8.5 nM. KT-531 exhibits strong inhibition against SUP-T11 cells with an IC50 of 0.42 μM. KT-531 can be used in study hematological cancers .
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-
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- HY-125818S2
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Cytidine triphosphate-<sup>13sup>C,d<sup>1sup> dilithium; 5'-CTP-<sup>13sup>C,d<sup>1sup> dilithium
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Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
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Infection
Cancer
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Cytidine-5'-triphosphate- 13C,d1 (Cytidine triphosphate- 13C,d1 dilithium; 5'-CTP- 13C,d1) dilithium is deuterium and 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
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-
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- HY-W067028S
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Aminourea-<sup>13sup>C,<sup>15sup>N2 hydrochloride; Hydrazinecarboxamide-<sup>13sup>C,<sup>15sup>N2 hydrochloride
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Isotope-Labeled Compounds
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Others
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Semicarbazide- 13C, 15N2 hydrochloride is 15N and 13C labeled Semicarbazide.
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-
-
- HY-Z0283S
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Benzenecarboxamide-<sup>15sup>N; Phenylamide-<sup>15sup>N
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Endogenous Metabolite
PARP
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Others
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Benzamide- 15N is a 15N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP)[1][2].
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-
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- HY-A0070AS1
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Triiodothyronine-<sup>13sup>C9,<sup>15sup>N; 3,3',5-Triiodo-L-thyronine-<sup>13sup>C9,<sup>15sup>N; T3-<sup>13sup>C9,<sup>15sup>N
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Thyroid Hormone Receptor
Endogenous Metabolite
|
|
Liothyronine- 13C9, 15N is the 13C and 15N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].
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-
-
- HY-B0215S1
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N-Acetylcysteine-<sup>15sup>N; N-Acetyl-L-cysteine-<sup>15sup>N; NAC-<sup>15sup>N
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Isotope-Labeled Compounds
Reactive Oxygen Species
Endogenous Metabolite
Apoptosis
Ferroptosis
Influenza Virus
|
Infection
Neurological Disease
|
Acetylcysteine- 15N (N-Acetylcysteine- 15N) is the 15N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].
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-
-
- HY-Y0504S2
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Hegzadesil-<sup>15sup>N; Trimethylamine hydrochloric acid-<sup>15sup>N; Trimethylamine monohydrochloride-<sup>15sup>N
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Endogenous Metabolite
|
Metabolic Disease
|
Trimethylammonium chloride- 15N is the 15N labeled Trimethylammonium chloride[1]. Trimethylammonium chloride is an endogenous metabolite.
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-
-
- HY-B0150S1
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Niacinamide-<sup>15sup>N,<sup>13sup>C3; Nicotinic acid amide-<sup>15sup>N,<sup>13sup>C3
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Endogenous Metabolite
Sirtuin
|
Neurological Disease
Cancer
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Nicotinamide- 15N, 13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
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-
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- HY-N0733S5
-
-
-
- HY-13417S
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Acadesine-<sup>13sup>C2,<sup>15sup>N; AICA Riboside-<sup>13sup>C2,<sup>15sup>N
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Isotope-Labeled Compounds
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Others
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AICAR- 13C2, 15N (Acadesine- 13C2, 15N; AICA Riboside- 13C2, 15N)is the 13C and 15N labeledAICAR(HY-13417) . AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .
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-
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- HY-B0178AS
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Guanidinium-<sup>13sup>C,<sup>15sup>N3 (chloride); Aminoformamidine-<sup>13sup>C,<sup>15sup>N3 (hydrochloride)
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Endogenous Metabolite
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Metabolic Disease
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Guanidine- 13C, 15N3 (hydrochloride)is the 13C-labeled and 15N-labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2].
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-
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- HY-N0650S5
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(-)-Serine-<sup>13sup>C3,<sup>15sup>N; (S)-Serine-<sup>13sup>C3,<sup>15sup>N
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Endogenous Metabolite
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Cancer
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L-Serine- 13C3, 15N is the 13C- and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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-
-
- HY-13677S1
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Mercaptopurine-<sup>13sup>C2,<sup>15sup>N; 6-MP-<sup>13sup>C2,<sup>15sup>N
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Nucleoside Antimetabolite/Analog
Autophagy
Endogenous Metabolite
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Cancer
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6-Mercaptopurine- 13C2, 15N is the 13C- and 15N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
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-
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- HY-N0091S1
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Purin-6-o-<sup>13sup>C,<sup>15sup>N2; Sarcine-<sup>13sup>C,<sup>15sup>N2
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Bacterial
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Infection
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Hypoxanthine- 13C, 15N2 is a 15N-labeled and 13C-labled Furaltadone. Furaltadone, a nitrofuran agent, has the potential for the study in infections of chickens with salmonella enteritidis. Furaltadone is inhibitory and bactericidal in vitro for staphylococci
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-
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- HY-N0091S3
-
-
-
- HY-13623S1
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BMS200475-<sup>13sup>C2,<sup>15sup>N; SQ34676-<sup>13sup>C2,<sup>15sup>N
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Isotope-Labeled Compounds
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Infection
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Entecavir- 13C2, 15N (BMS200475- 13C2, 15N; SQ34676- 13C2, 15N) is a 13C- and 15N-labeled Entecavir (HY-13623). Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
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-
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- HY-14164S1
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-
-
- HY-N0667S4
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(-)-Asparagine-4-<sup>13sup>C monohydrate; Asn-4-<sup>13sup>C monohydrate; Asparamide-4-<sup>13sup>C monohydrate
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Isotope-Labeled Compounds
Endogenous Metabolite
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Neurological Disease
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L-Asparagine-4- 13C (monohydrate) is the 13C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
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-
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- HY-Y0418S1
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Dulcitol-<sup>13sup>C-1; Melampyrit-<sup>13sup>C-1; NSC 1944-<sup>13sup>C-1
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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Dulcite- 13C-1 is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
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-
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- HY-Y0418S2
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Dulcitol-<sup>13sup>C-2; Melampyrit-<sup>13sup>C-2; NSC 1944-<sup>13sup>C-2
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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Dulcite- 13C-2 is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
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-
- HY-Y0418S3
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Dulcitol-<sup>13sup>C-3; Melampyrit-<sup>13sup>C-3; NSC 1944-<sup>13sup>C-3
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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Dulcite- 13C-3 is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
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-
- HY-B0617S1
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S-Adenosyl methionine-<sup>13sup>C; Ademetionine-<sup>13sup>C; AdoMet--<sup>13sup>C
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Endogenous Metabolite
|
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S-Adenosyl-L-methionine- 13C is the 13C labeled S-Adenosyl-L-methionine[1]. S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research[2][3][4].
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-
- HY-Y0842S
-
-
- HY-101037S
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N-Methylglycine-<sup>15sup>N; Sarcosin-<sup>15sup>N
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Endogenous Metabolite
GlyT
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Cancer
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Sarcosine- 15N is the 15N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
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- HY-N0623S1
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Tryptophan-<sup>13sup>C; Tryptophane-<sup>13sup>C
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Endogenous Metabolite
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Metabolic Disease
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L-Tryptophan- 13C is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
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- HY-N0623S7
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-
- HY-N0378S1
-
-
- HY-N0733S
-
-
- HY-N1150S2
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- HY-N0733S4
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-
- HY-N0545S
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Sodium taurocholate-<sup>13sup>C2,<sup>15sup>N; N-Choloyltaurine-<sup>13sup>C2,<sup>15sup>N (sodium)
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VEGFR
Endogenous Metabolite
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Inflammation/Immunology
|
Taurocholic acid- 13C2, 15N (sodium) is the 13C- and 15N- labeled Taurocholic acid (sodium).
|
-
- HY-14291S2
-
LAF237-<sup>13sup>C5,<sup>15sup>N; NVP-LAF 237-<sup>13sup>C5,<sup>15sup>N
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Vildagliptin- 13C5, 15N (LAF237- 13C5, 15N; NVP-LAF 237- 13C5, 15N) is a 13C- and 15N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
|
-
- HY-B0389S11
-
Glucose-<sup>13sup>C-1; D-(+)-Glucose-<sup>13sup>C-1; Dextrose-<sup>13sup>C-1
|
Endogenous Metabolite
|
Metabolic Disease
|
D-Glucose- 13C-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-B0389S12
-
Glucose-<sup>13sup>C-2; D-(+)-Glucose-<sup>13sup>C-2; Dextrose-<sup>13sup>C-2
|
Endogenous Metabolite
|
Metabolic Disease
|
D-Glucose- 13C-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-B0389S16
-
Glucose-<sup>13sup>C-4; D-(+)-Glucose-<sup>13sup>C-4; Dextrose-<sup>13sup>C-4
|
Endogenous Metabolite
|
Metabolic Disease
|
D-Glucose- 13C-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-B0389S17
-
Glucose-<sup>13sup>C-5; D-(+)-Glucose-<sup>13sup>C-5; Dextrose-<sup>13sup>C-5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
D-Glucose- 13C-5 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-B0389S13
-
Glucose-<sup>13sup>C-3; D-(+)-Glucose-<sup>13sup>C-3; Dextrose-<sup>13sup>C-3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
D-Glucose- 13C-3 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-W338294S
-
Deoxycytidine-<sup>13sup>C (monohydrate); Cytosine deoxyriboside-<sup>13sup>C (monohydrate); Deoxyribose cytidine-<sup>13sup>C (monohydrate)
|
Endogenous Metabolite
|
Others
|
2'-Deoxycytidine- 13C (monohydrate) is the 13C labeled 2'-Deoxycytidine[1].
|
-
- HY-B0389S30
-
Glucose-<sup>18sup>O-1; D-(+)-Glucose-<sup>18sup>O-1; Dextrose-<sup>18sup>O-1
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
D-Glucose- 18O-1 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
|
-
- HY-B0389S31
-
Glucose-<sup>18sup>O-2; D-(+)-Glucose-<sup>18sup>O-2; Dextrose-<sup>18sup>O-2
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
D-Glucose- 18O-2 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
|
-
- HY-B0389S32
-
Glucose-<sup>18sup>O-3; D-(+)-Glucose-<sup>18sup>O-3; Dextrose-<sup>18sup>O-3
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
D-Glucose- 18O-3 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
|
-
- HY-B0389S19
-
Glucose-<sup>13sup>C,d; D-(+)-Glucose-<sup>13sup>C,d; Dextrose-<sup>13sup>C,d
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sign
|
-
- HY-N0537S2
-
-
- HY-N0537S3
-
-
- HY-N0537S4
-
-
- HY-N0537S5
-
-
- HY-N0537S6
-
-
- HY-N0537S
-
-
- HY-16637S4
-
Vitamin B9-<sup>13sup>C5,<sup>15sup>N; Vitamin M-<sup>13sup>C5,<sup>15sup>N
|
Isotope-Labeled Compounds
|
Others
|
Folic acid- 15N, 13C5 is the 13C5 and 15N labeled Folic acid (HY-16637) .
|
-
- HY-N0157S1
-
6-Carboxyuracil-<sup>13sup>C,<sup>15sup>N2 monohydrate; Vitamin B13-<sup>13sup>C,<sup>15sup>N2 monohydrate
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Metabolic Disease
|
Orotic acid- 13C, 15N2 (monohydrate) is the 13C and 15N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].
|
-
- HY-N0650S1
-
(-)-Serine-<sup>13sup>C; (S)-Serine-<sup>13sup>C
|
Endogenous Metabolite
|
Cancer
|
L-Serine- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-N0650S10
-
(-)-Serine-<sup>15sup>N; (S)-Serine-<sup>15sup>N
|
Endogenous Metabolite
|
Cancer
|
L-Serine- 15N is the 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-B0400S1
-
Sorbitol-<sup>13sup>C; D-Glucitol-<sup>13sup>C
|
Endogenous Metabolite
|
Others
|
D-Sorbitol- 13C is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary s
|
-
- HY-B0228S5
-
-
- HY-D0844S
-
L-Glutathione oxidized-<sup>13sup>C4,<sup>15sup>N2; GSSG-<sup>13sup>C4,<sup>15sup>N2; Oxiglutatione-<sup>13sup>C4,<sup>15sup>N2
|
Endogenous Metabolite
Reactive Oxygen Species
|
Metabolic Disease
|
Glutathione oxidized- 13C4, 15N2 is the 13C and 15N labeled Glutathione oxidized (HY-D0844). Glutathione oxidized is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes[1][2].
|
-
- HY-D0184S3
-
Deoxycytidine-<sup>13sup>C9,<sup>15sup>N3; Cytosine deoxyriboside-<sup>13sup>C9,<sup>15sup>N3; Deoxyribose cytidine-<sup>13sup>C9,<sup>15sup>N3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
2'-Deoxycytidine- 13C9, 15N3 (Deoxycytidine- 13C9, 15N3; Cytosine deoxyriboside- 13C9, 15N3; Deoxyribose cytidine- 13C9, 15N3) is 13C and 15N-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
|
-
- HY-106950CS
-
-
- HY-106950CS1
-
-
- HY-106950CS3
-
-
- HY-N1480S1
-
6-Desoxygalactose-<sup>13sup>C-1; L-(-)-Fucose-<sup>13sup>C-1; L-Galactomethylose-<sup>13sup>C-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
Parasite
|
Infection
Metabolic Disease
|
(-)-Fucose- 13C-1 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
|
-
- HY-N1480S2
-
6-Desoxygalactose-<sup>13sup>C-2; L-(-)-Fucose-<sup>13sup>C-2; L-Galactomethylose-<sup>13sup>C-2
|
Isotope-Labeled Compounds
Endogenous Metabolite
Parasite
|
Infection
Metabolic Disease
|
(-)-Fucose- 13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
|
-
- HY-N1480S3
-
6-Desoxygalactose-<sup>13sup>C-3; L-(-)-Fucose-<sup>13sup>C-3; L-Galactomethylose-<sup>13sup>C-3
|
Isotope-Labeled Compounds
Endogenous Metabolite
Parasite
|
Infection
Metabolic Disease
|
(-)-Fucose- 13C-3 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
|
-
- HY-N0230S
-
2-Carboxyethylamine-<sup>13sup>C3,<sup>15sup>N; 3-Aminopropanoic acid-<sup>13sup>C3,<sup>15sup>N
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
β-Alanine- 13C3, 15N is the 13C- and 15N-labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
|
-
- HY-N0091S4
-
-
- HY-15129S
-
L-Serine O-phosphate-<sup>13sup>C3,<sup>15sup>N; L-SOP-<sup>13sup>C3,<sup>15sup>N
|
mGluR
Endogenous Metabolite
|
Neurological Disease
|
O-Phospho-L-serine- 13C3, 15N is the 13C- and 15N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2[1].
|
-
- HY-138253S
-
dFdU-<sup>13sup>C,<sup>15sup>N2; 2',2'-Difluoro-2'-deoxyuridine-<sup>13sup>C,<sup>15sup>N2
|
Isotope-Labeled Compounds
|
Others
|
2′,2′-Difluorodeoxyuridine- 13C, 15N2 (dFdU- 13C, 15N2; 2',2'-Difluoro-2'-deoxyuridine- 13C, 15N2) is a 13C- and 15N-labeled compound.
|
-
- HY-N0593S3
-
-
- HY-100582S
-
Adonitol-1-<sup>13sup>C; Adonite-1-<sup>13sup>C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Ribitol-1- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-100582S1
-
Adonitol-2-<sup>13sup>C; Adonite-2-<sup>13sup>C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Ribitol-2- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-100582S2
-
Adonitol-3-<sup>13sup>C; Adonite-3-<sup>13sup>C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Ribitol-3- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-100582S3
-
Adonitol-5-<sup>13sup>C; Adonite-5-<sup>13sup>C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Ribitol-5- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-I0400S
-
-
- HY-163080S
-
<sup>77sup>Se
|
Isotope-Labeled Compounds
|
Others
|
Selenium-77 (77Se) is a stable (non-radioactive) isotope of Selenium. Selenium-77 is both naturally occurring and produced by fission.
|
-
- HY-B0139S
-
5-Fluorocytosine-<sup>13sup>C,15sup>N2; NSC 103805-<sup>13sup>C,15sup>N2; Ro 2-9915-<sup>13sup>C,15sup>N2
|
Isotope-Labeled Compounds
|
Infection
|
Flucytosine- 13C, 15N2 (NSC 103805- 13C, 15N2; Ro 2-9915- 13C, 15N2) is a 13C- and 15N-labeled Flucytosine (HY-B0139).
|
-
- HY-16637S2
-
(Rac)-Vitamin B9-<sup>13sup>C5,<sup>15sup>N; (Rac)-Vitamin M-<sup>13sup>C5,<sup>15sup>N
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
(Rac)-Folic acid- 13C5, 15N is the 13C-labeled and 15N-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
|
-
- HY-N1150S8
-
DThyd-<sup>13sup>C10,<sup>15sup>N2; NSC-<sup>13sup>C10,<sup>15sup>N2
|
DNA/RNA Synthesis
Endogenous Metabolite
Orthopoxvirus
|
Cancer
|
Thymidine- 13C10, 15N2 is the 13C and 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
|
-
- HY-B1092AS
-
D-Gluconic acid sodium salt-1-<sup>13sup>C; Sodium D-gluconate-1-<sup>13sup>C; D-Gluconate sodium salt-1-<sup>13sup>C
|
Endogenous Metabolite
|
Others
|
Gluconate-1- 13C (sodium) is the 13C labeled Gluconate sodi[1][2].
|
-
- HY-N0623S4
-
Tryptophan-<sup>13sup>C11,<sup>15sup>N2; Tryptophane-<sup>13sup>C11,<sup>15sup>N2
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Tryptophan- 13C11, 15N2 is the 13C- and 15N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
|
-
- HY-D0187S
-
-
- HY-N0097S6
-
DL-Guanosine-<sup>13sup>C10,<sup>15sup>N5; Vernine-<sup>13sup>C10,<sup>15sup>N5
|
HSV
Isotope-Labeled Compounds
|
Infection
|
Guanosine- 13C10, 15N5 is the 13C and 15N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .
|
-
- HY-N0623S3
-
-
- HY-B0166S1
-
L-Ascorbate-<sup>13sup>C; Vitamin C-<sup>13sup>C
|
Reactive Oxygen Species
Calcium Channel
Apoptosis
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
Cancer
|
L-Ascorbic acid- 13C is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
|
-
- HY-W338294S2
-
Deoxyguanosine-<sup>13sup>C (monohydrate); Guanine deoxyriboside-<sup>13sup>C (monohydrate)
|
Endogenous Metabolite
|
Others
|
2'-Deoxyguanosine- 13C (monohydrate) Monohydrate is the 13C labeled 2'-Deoxyguanosine[1].
|
-
- HY-N2353S
-
(±)-Arabinose-1-<sup>13sup>C; DL-Arabinose-1-<sup>13sup>C
|
Endogenous Metabolite
|
Others
|
Arabinose-1- 13C is the 13C labeled Arabinose. Arabinose is an endogenous metabolite[1].
|
-
- HY-N0378S3
-
-
- HY-N0733S1
-
-
- HY-N0733S3
-
-
- HY-128850S1
-
N-Acetylmannosamine-<sup>13sup>C; ManNAc-<sup>13sup>C
|
Bacterial
|
Neurological Disease
|
N-Acetyl-D-mannosamine- 13C is the 13C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1][2]
|
-
- HY-N1150S4
-
-
- HY-N1150S3
-
-
- HY-128850S5
-
N-Acetylmannosamine-<sup>15sup>N; ManNAc-<sup>15sup>N
|
Isotope-Labeled Compounds
Bacterial
|
Neurological Disease
|
N-Acetyl-D-mannosamine- 15N is the 15N labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1][2]
|
-
- HY-108213S
-
5'-IMP-<sup>13sup>C10,<sup>15sup>N4 dilithium; IMP-<sup>13sup>C10,<sup>15sup>N4 dilithium; Inosine 5'-dihydrogen phosphate-<sup>13sup>C10,<sup>15sup>N4 dilithium
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Inosinic acid- 13C10, 15N4 dilithium (5'-IMP-13C10,15N4 (dilithium); IMP-13C10,15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-13C10,15N4 (dilithium)) is 13C- and 15N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .
|
-
- HY-N0305S
-
5-ALA-<sup>15sup>N hydrochloride; δ-Aminolevulinic acid-<sup>15sup>N hydrochloride; 5-Amino-4-oxopentanoic acid-<sup>15sup>N hydrochloride
|
Isotope-Labeled Compounds
Autophagy
Mitophagy
Endogenous Metabolite
Apoptosis
|
Metabolic Disease
Cancer
|
5-Aminolevulinic acid- 15N (hydrochloride) is the 15N-labeled 5-Aminolevulinic acid (hydrochloride). 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
|
-
- HY-W000450S
-
5-ALA-<sup>13sup>C; δ-Aminolevulinic acid-<sup>13sup>C; 5-Amino-4-oxopentanoic acid-<sup>13sup>C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
|
5-Aminolevulinic acid- 13C is the 13C-labeled 5-Aminolevulinic acid. 5-Aminolevulinic acid (5-ALA) is a non-protein amino acid that plays a rate-limiting role in heme biosynthesis.
|
-
- HY-W338294S1
-
Deoxycytidine-<sup>13sup>C-2 (monohydrate); Cytosine deoxyriboside-<sup>13sup>C-2 (monohydrate); Deoxyribose cytidine-<sup>13sup>C-2 (monohydrate)
|
Endogenous Metabolite
|
Others
|
2'-Deoxycytidine- 13C-2 (monohydrate) Monohydrate is the 13C labeled 2'-Deoxycytidine[1].
|
-
- HY-N0305S2
-
5-ALA-<sup>13sup>C hydrochloride; δ-Aminolevulinic acid-<sup>13sup>C hydrochloride; 5-Amino-4-oxopentanoic acid-<sup>13sup>C hydrochloride
|
Apoptosis
Autophagy
Mitophagy
Endogenous Metabolite
|
|
5-Aminolevulinic acid- 13C (hydrochloride) is the 13C labeled 5-Aminolevulinic acid hydrochloride[1]. 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles[2][3].
|
-
- HY-140015A
-
|
PROTAC Linkers
|
Cancer
|
(S)-TCO-PEG3-acid is a click chemistry PEG linker with a terminal carboxylic acid(COOH) group. The terminal carboxylic acid is reactive with primary amine groups to form a stable amide bond. (S)-TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-N0091S
-
-
- HY-B1118S1
-
RP-14539-<sup>13sup>C2, <sup>15sup>N2; PM-185184-<sup>13sup>C2, <sup>15sup>N2
|
Isotope-Labeled Compounds
Parasite
Antibiotic
|
Infection
|
Secnidazole- 13C2, 15N2 is the 13C2, 15N2 labeled Secnidazole. Secnidazole (RP-14539;PM-185184) is an orally active azole antibiotic with a longer half-life than metronidazole (HY-B0318). Secnidazole is against the vaginosis-associated bacteria and has the potential for bacterial vaginosis research.
|
-
- HY-17563S1
-
Deoxyguanosine-<sup>13sup>C10,<sup>15sup>N5; Guanine deoxyriboside-<sup>13sup>C10,<sup>15sup>N5
|
Isotope-Labeled Compounds
|
Cancer
|
2'-Deoxyguanosine- 13C10, 15N5 (Deoxyguanosine- 13C10, 15N5; Guanine deoxyriboside- 13C10, 15N5) is a 13C- and 15N-labeled 2'-Deoxyguanosine (HY-17563).
|
-
- HY-B0456S
-
Vitamin B2-<sup>13sup>C4,<sup>15sup>N2; E101-<sup>13sup>C4,<sup>15sup>N2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Riboflavin- 13C4, 15N2is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-Y0219S
-
s-Triazole<sup>13sup>C2,<sup>15sup>N3; Pyrrodiazole<sup>13sup>C2,<sup>15sup>N3
|
Isotope-Labeled Compounds
|
Others
|
NSC 83128- 13C2, 15N3 is the 13C and 15N labeled NSC 83128[1].
|
-
- HY-107372S
-
-
- HY-W011240S1
-
Methforylthiazidine-<sup>15sup>N2,<sup>13sup>C,d2; Rontyl-<sup>15sup>N2,<sup>13sup>C,d2
|
Isotope-Labeled Compounds
|
Others
|
Hydroflumethiazide- 15N2, 13C,d2 is the 13C- and 15N-labeled Hydroflumethiazide[1].
|
-
- HY-B0152S2
-
6-Aminopurine-<sup>13sup>C5,<sup>15sup>N5; Vitamin B4-<sup>13sup>C5,<sup>15sup>N5
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
Adenine- 13C5,15C5 (6-Aminopurine- 13C5,15C5; Vitamin B4- 13C5,15C5) is 13C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
|
-
- HY-118560S
-
NSC 6598-<sup>13sup>C2; Herbaflorat-<sup>13sup>C2; Greenyl acetate-<sup>13sup>C2; Verdyl acetate-<sup>13sup>C2
|
Isotope-Labeled Compounds
|
Others
|
Tricyclodecenyl acetate- 13C2 is 13C labeled 2-Acetylthiazole.
|
-
- HY-A0161S
-
Clofedanol-<sup>13sup>C6; Calmotusin-<sup>13sup>C6; NSC 113595-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Infection
|
Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2][3].
|
-
- HY-N0667S2
-
(-)-Asparagine-<sup>15sup>N2 monohydrate; Asn-<sup>15sup>N2 monohydrate; Asparamide-<sup>15sup>N2 monohydrate
|
Endogenous Metabolite
|
Neurological Disease
|
L-Asparagine- 15N2 (monohydrate) is the 15N-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
|
-
- HY-N0667S3
-
(-)-Asparagine-<sup>13sup>C4 monohydrate; Asn-<sup>13sup>C4 monohydrate; Asparamide-<sup>13sup>C4 monohydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
|
L-Asparagine- 13C4 (monohydrate) is the 13C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
|
-
- HY-N0898S
-
-
- HY-13966S2
-
2-DG-<sup>13sup>C; 2-Deoxy-D-arabino-hexose-<sup>13sup>C; D-Arabino-2-deoxyhexose-<sup>13sup>C
|
Isotope-Labeled Compounds
Apoptosis
Hexokinase
HSV
|
Cancer
|
2-Deoxy-D-glucose- 13C is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].
|
-
- HY-W015824S1
-
-
- HY-N0230S1
-
2-Carboxyethylamine-<sup>15sup>N; 3-Aminopropanoic acid-<sup>15sup>N
|
Endogenous Metabolite
|
Metabolic Disease
|
β-Alanine- 15N is the 15N-labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
|
-
- HY-N0650S2
-
(-)-Serine-1-<sup>13sup>C; (S)-Serine-1-<sup>13sup>C
|
Endogenous Metabolite
|
Cancer
|
L-Serine-1- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-N0650S4
-
(-)-Serine-2-<sup>13sup>C; (S)-Serine-2-<sup>13sup>C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
L-Serine-2- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-B0400S2
-
Sorbitol-<sup>13sup>C-1; D-Glucitol-<sup>13sup>C-1
|
Endogenous Metabolite
|
Others
|
D-Sorbitol- 13C-1 is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
|
-
- HY-B0400S3
-
Sorbitol-<sup>13sup>C-2; D-Glucitol-<sup>13sup>C-2
|
Endogenous Metabolite
|
Others
|
D-Sorbitol- 13C-2 is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
|
-
- HY-B0400S15
-
Sorbitol-<sup>18sup>O-1; D-Glucitol-<sup>18sup>O-1
|
Endogenous Metabolite
|
Others
|
D-Sorbitol- 18O-1 is the 18O labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
|
-
- HY-B0228S4
-
-
- HY-B0228S2
-
-
- HY-B0228S3
-
-
- HY-B0226S
-
Nitrofural-<sup>13sup>C,<sup>15sup>N2
|
Isotope-Labeled Compounds
|
Infection
|
Nitrofurazone- 13C, 15N2 (Nitrofural- 13C, 15N2) is the 13C and 15N labled Nitrofurazone (HY-B0226) . Nitrofurazone is a potential antibiotic that can be used topically to treat wounds, burns, ulcers and skin infections to combat various microorganisms and to prepare surfactants . Nitrofurazone may affect the ecosystem function in Marine environment and affect the functional processes of epiphytic fauna .
|
-
- HY-10572S1
-
-
- HY-B0389A
-
Glucose-<sup>13sup>C6; D-(+)-Glucose-<sup>13sup>C6; Dextrose-<sup>13sup>C6
|
Endogenous Metabolite
|
Others
Metabolic Disease
|
D-Glucose- 13C6 is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose- 13C6 can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard .
|
-
- HY-B0389S14
-
Glucose-<sup>13sup>C2; D-(+)-Glucose-<sup>13sup>C2; Dextrose-<sup>13sup>C2
|
Endogenous Metabolite
|
Metabolic Disease
|
D-Glucose- 13C2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-B0375S1
-
MD-805-<sup>13sup>C6 hydrochloride; MCI-9038-<sup>13sup>C6 hydrochloride; Argipidine-<sup>13sup>C6 hydrochloride
|
Thrombin
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
Argatroban- 13C6 hydrochloride is 13C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.
|
-
- HY-N0650S3
-
(-)-Serine-<sup>13sup>C3,<sup>15sup>N,d3; (S)-Serine-<sup>13sup>C3,<sup>15sup>N,d3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
L-Serine- 13C3, 15N,d3 is the deuterium, 13C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-B0141S4
-
β-Estradiol-<sup>13sup>C6; E2-<sup>13sup>C6; 17β-Estradiol-<sup>13sup>C6; 17β-Oestradiol-<sup>13sup>C6
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
Estradiol- 13C6 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
|
-
- HY-B0141S5
-
β-Estradiol-<sup>13sup>C2; E2-<sup>13sup>C2; 17β-Estradiol-<sup>13sup>C2; 17β-Oestradiol-<sup>13sup>C2
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
Estradiol- 13C2 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
|
-
- HY-16973S
-
A1443-<sup>13sup>C2,<sup>15sup>N,d3; AH252723-<sup>13sup>C2,<sup>15sup>N,d3
|
Isotope-Labeled Compounds
Parasite
|
Infection
|
Fluralaner- 13C2, 15N,d3 is the deuterium, 13C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
|
-
- HY-150712S
-
UTP-<sup>13sup>C9,<sup>15sup>N2 dilithium; Uridine 5'-triphosphate-<sup>13sup>C9,<sup>15sup>N2 dilithium
|
Isotope-Labeled Compounds
|
Others
|
Uridine triphosphate- 13C9, 15N5 dilithium is the 13C and 15N labeled Uridine triphosphate dilithium .
|
-
- HY-N0717S1
-
Valine-<sup>13sup>C5,<sup>15sup>N
|
Endogenous Metabolite
|
Others
|
L-Valine- 13C5, 15N is the 13C- and 15N-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
- HY-B0503S
-
Thiouracil-<sup>13sup>C,<sup>15sup>N2
|
Isotope-Labeled Compounds
NO Synthase
|
Endocrinology
Cancer
|
2-Thiouracil- 13C, 15N2 is the 13C, 15N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.
|
-
- HY-I0400S1
-
-
- HY-I0400S2
-
-
- HY-I0400S3
-
-
- HY-B0003S
-
LY 188011-<sup>13sup>C,<sup>15sup>N2 hydrochloride
|
Apoptosis
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
Autophagy
|
Cancer
|
Gemcitabine- 13C, 15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride[1]. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2][3].
|
-
- HY-B0211S
-
PK 26124-<sup>13sup>C,<sup>15sup>N2
|
GABA Receptor
Sodium Channel
|
|
Riluzole- 13C, 15N2 is the 13C and 15N labeled Riluzole[1]. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].
|
-
- HY-W015824S5
-
DL-Asp-OH-<sup>13sup>C,<sup>15sup>N- hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
DL-Aspartic acid- 13C, 15N-1 hydrochloride is the 13C and 15N labeled DL-Aspartic acid.
|
-
- HY-W010918S
-
Adenosine diphosphate-d<sup>13sup> dilithium; ADP--d<sup>13sup> dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Adenosine 5'-diphosphate-d13 (Adenosine diphosphate-d13 dilithium; ADP-d13) dilithium is deuterium labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
|
-
- HY-B0149S3
-
Cyclocapron-<sup>13sup>C2,<sup>15sup>N
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
Tranexamic acid- 13C2, 15N (Cyclocapron- 13C2, 15N) is the 13C2 and 15N labeled Tranexamic acid. Tranexamic acid is an antifibrinolytic agent that alleviates liver damage and fibrosis in mouse models of chronic bile duct injury .
|
-
- HY-A0003S2
-
CC-5013-<sup>13sup>C5,<sup>15sup>N
|
Ligands for E3 Ligase
Apoptosis
Molecular Glues
Isotope-Labeled Compounds
|
Inflammation/Immunology
Cancer
|
Lenalidomide- 13C5, 15N is 15N and 13C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .
|
-
- HY-10984S3
-
CC-4047-<sup>15sup>N,<sup>13sup>C5
|
Molecular Glues
Apoptosis
Ligands for E3 Ligase
Isotope-Labeled Compounds
|
Cancer
|
Pomalidomide- 15N, 13C5 is 15N and 13C labeled Pomalidomide (HY-10984). Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
|
-
- HY-13948BS
-
Angiotensin II-13sup>C6,<sup>15sup>N TFA; Ang II-13sup>C6,<sup>15sup>N TFA; DRVY(I-13sup>C6,<sup>15sup>N)HPF TFA
|
Isotope-Labeled Compounds
|
Cancer
|
Angiotensin II human- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
|
-
- HY-50896S1
-
CP-358774-<sup>13sup>C6; NSC 718781-<sup>13sup>C6; OSI-774-<sup>13sup>C6
|
Isotope-Labeled Compounds
EGFR
Autophagy
|
Cancer
|
Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].
|
-
- HY-12008S1
-
CP-358774-<sup>13sup>C6 hydrochloride; NSC 718781-<sup>13sup>C6 hydrochloride; OSI-774-<sup>13sup>C6 hydrochloride
|
EGFR
Autophagy
|
Cancer
|
Erlotinib- 13C6 (hydrochloride) is the 13C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2]. Erlotinib-13C6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-15027S2
-
Mesalamine-<sup>13sup>C6; 5-ASA-<sup>13sup>C6; Mesalazine-<sup>13sup>C6
|
PPAR
PAK
NF-κB
Endogenous Metabolite
|
|
5-Aminosalicylic acid- 13C6 is the 13C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].
|
-
- HY-D0184S2
-
Deoxycytidine-<sup>15sup>N3; Cytosine deoxyriboside-<sup>15sup>N3; Deoxyribose cytidine-<sup>15sup>N3
|
Endogenous Metabolite
|
Others
|
2'-Deoxycytidine- 15N3 is the 15N labeled 2'-Deoxycytidine[1]. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu)[2].
|
-
- HY-D0184S5
-
Deoxycytidine-<sup>13sup>C9; Cytosine deoxyriboside-<sup>13sup>C9; Deoxyribose cytidine-<sup>13sup>C9
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
2'-Deoxycytidine- 13C9 (Deoxycytidine- 13C9; Cytosine deoxyriboside- 13C9; Deoxyribose cytidine- 13C9) is 13C-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
|
-
- HY-143704S
-
Mesalamine-<sup>13sup>C6 hydrochloride; 5-ASA-<sup>13sup>C6 hydrochloride; Mesalazine-<sup>13sup>C6 hydrochloride
|
PPAR
NF-κB
PAK
|
Metabolic Disease
|
5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
|
-
- HY-B0456S1
-
Vitamin B2-<sup>13sup>C4,<sup>15sup>N2-1; E101-<sup>13sup>C4,<sup>15sup>N2-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Riboflavin-5-Phosphate- 13C4, 15N2-1 is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-B0158S5
-
Cytosine β-D-riboside-<sup>13sup>C9,<sup>15sup>N3; Cytosine-1-β-D-ribofuranoside-<sup>13sup>C9,<sup>15sup>N3
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Neurological Disease
|
Cytidine- 13C9, 15N3 is the 13C and 15N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].
|
-
- HY-N5134S5
-
5'-GMP-<sup>13sup>C10,<sup>15sup>N5 dilithium; 5'-guanosine monophosphate-<sup>13sup>C10,<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
5'-Guanylic acid- 13C10, 15N5 (5'-GMP- 13C10, 15N5 dilithium; 5'-guanosine monophosphate- 13C10, 15N5) dilithium is 13C and 15N-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
|
-
- HY-W009162S5
-
5'-Cytidylic acid-<sup>13sup>C9,<sup>15sup>N3 dilithium; 5'-CMP-<sup>13sup>C9,<sup>15sup>N3 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
Cytidine 5′-monophosphate- 13C9, 15N3 (5'-Cytidylic acid- 13C9, 15N3 dilithium; 5'-CMP- 13C9, 15N3) dilithium is 13C and 15N-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
|
-
- HY-101400S2
-
dCTP-<sup>13sup>C9,<sup>15sup>N3 dilithium; 2′-Deoxycytidine-5′-triphosphate-<sup>13sup>C9,<sup>15sup>N3 dilithium
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
Endogenous Metabolite
|
Metabolic Disease
|
Deoxycytidine triphosphate- 13C9, 15N3 (dCTP- 13C9, 15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate- 13C9, 15N3) dilithium is 13C and 15N-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
|
-
- HY-17413S1
-
Azidothymidine-<sup>13sup>C,d3; AZT-<sup>13sup>C,d3; ZDV-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
HIV
CRISPR/Cas9
|
Infection
|
Zidovudine- 13C,d3 is the 13C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-106950S1
-
Diphosphofructose-<sup>13sup>C6 tetrasodium hydrate; Esafosfan-<sup>13sup>C6 tetrasodium hydrate; FDP-<sup>13sup>C6 tetrasodium hydrate
|
Endogenous Metabolite
|
Cardiovascular Disease
|
Fosfructose- 13C6 (tetrasodium hydrate) is the 13C labeled Fosfructose (HY-106950). Fosfructose is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma[1].
|
-
- HY-B1431S1
-
Butyl parahydroxybenzoate-<sup>13sup>C6; Butyl paraben-<sup>13sup>C6; Butyl 4-hydroxybenzoate-<sup>13sup>C6
|
Bacterial
Endogenous Metabolite
|
Infection
|
Butylparaben- 13C6 is the 13C labeled Butylparaben[1]. Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.
|
-
- HY-N0305S3
-
5-ALA-<sup>13sup>C-1 hydrochloride; δ-Aminolevulinic acid-<sup>13sup>C-1 hydrochloride; 5-Amino-4-oxopentanoic acid-<sup>13sup>C-1 hydrochloride
|
Apoptosis
Autophagy
Mitophagy
Endogenous Metabolite
|
|
5-Aminolevulinic acid- 13C-1 (5-ALA- 13C-1) hydrochloride is the 13C labeled 5-Aminolevulinic acid hydrochloride . 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles .
|
-
- HY-B0139AS
-
5-Fluorocytosine-<sup>15sup>N3 hydrochloride; NSC 103805-<sup>15sup>N3 hydrochloride; Ro 2-9915-<sup>15sup>N3 hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
Flucytosine- 15N3 hydrochloride is 15N labeled Flucytosine.
|
-
- HY-B1290S3
-
-
- HY-N0229S
-
-
- HY-Y0271S
-
Carbamide-<sup>15sup>N2; Carbonyldiamide-<sup>15sup>N2
|
Endogenous Metabolite
|
Cardiovascular Disease
Cancer
|
Urea- 15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
- HY-N1446S
-
-
- HY-N0229S11
-
-
- HY-B0351S2
-
2-Aminoethanesulfonic acid-<sup>13sup>C2,<sup>15sup>N
|
Isotope-Labeled Compounds
Autophagy
Endogenous Metabolite
|
Metabolic Disease
|
Taurine- 13C2, 15N is the 13C- and 15N- labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes[1][2][3].
|
-
- HY-B0035S2
-
-
- HY-A0253S
-
-
- HY-B0166S2
-
-
- HY-B0166S3
-
-
- HY-B0166S4
-
-
- HY-B0166S5
-
-
- HY-128850S2
-
N-Acetylmannosamine-<sup>13sup>C-1; ManNAc-<sup>13sup>C-1
|
Isotope-Labeled Compounds
Bacterial
|
Neurological Disease
|
N-Acetyl-D-mannosamine- 13C-1 is the 13C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1][2]
|
-
- HY-90006S1
-
5-FU-<sup>13sup>C,<sup>15sup>N2
|
Apoptosis
Nucleoside Antimetabolite/Analog
HIV
Endogenous Metabolite
|
Cancer
|
5-Fluorouracil- 13C, 15N2 is the 13C and 15N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].
|
-
- HY-N1150S9
-
DThyd-<sup>15sup>N2; NSC-<sup>15sup>N2
|
DNA/RNA Synthesis
Endogenous Metabolite
Orthopoxvirus
|
Cancer
|
Thymidine- 15N2 is the 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
|
-
- HY-W018603S
-
-
- HY-B1449S9
-
β-Uridine-<sup>13sup>C,<sup>15sup>N2
|
Isotope-Labeled Compounds
|
Cancer
|
Uridine- 13C, 15N2 (β-Uridine- 13C, 15N2) is a 13C- and 15N-labeled Uridine (HY-B1449).
|
-
- HY-111095S1
-
(R)-2-Hydroxypropionic acid-<sup>13sup>C; D-Lactic acid-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Others
|
D-(-)-Lactic acid-13C ((R)-2-Hydroxypropionic acid-13C) is a 13C-labeled D-Lactic acid. D-(-)-Lactic acid-13C can be used as an internal standard and can also be used in studies such as metabolic tracing.
|
-
- HY-77956S
-
Deoxyribose-<sup>13sup>C
|
Endogenous Metabolite
|
Others
|
Thyminose- 13C is the 13C labeled Thyminose. Thyminose is an endogenous metabolite[1].
|
-
- HY-N2840S
-
Allodulcitol-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
Allitol- 13C is the 13C labeled Allitol. Allitol is a rare natural polyol that can be used as a sweetener. Allitol is an important intermediate for the preparation of the agents which against diabetes, cancer, and viral infections, including AIDS[1]
|
-
- HY-B1659S1
-
-
- HY-107801
-
Imunovir; Delimmun; Groprinosin
|
Interleukin Related
HSV
HIV
HPV
|
Infection
Inflammation/Immunology
|
Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus
[5].
|
-
- HY-Y0721S
-
m-Bromofluorobenzene-<sup>13sup>C6; m-Fluorobromobenzene-<sup>13sup>C6; m-Fluorophenyl bromide-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Others
|
3-Bromofluorobenzene- 13C6 is the 13C labeled 3-Bromofluorobenzene[1].
|
-
- HY-13966S4
-
2-DG-<sup>13sup>C-1; 2-Deoxy-D-arabino-hexose-<sup>13sup>C-1; D-Arabino-2-deoxyhexose-<sup>13sup>C-1
|
Isotope-Labeled Compounds
Apoptosis
Hexokinase
HSV
|
Cancer
|
2-Deoxy-D-glucose- 13C-1 is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].
|
-
- HY-N0055S
-
3-O-Caffeoylquinic acid-13C<sup>3sup>; Heriguard-13C<sup>3sup>; NSC-407296-13C<sup>3sup>
|
Isotope-Labeled Compounds
|
Cancer
|
Chlorogenic acid- 13C3 (Heriguard- 13C3; NSC-407296- 13C3) is 13C- and 15N-labeled Chlorogenic acid (HY-N0055). Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension .
|
-
- HY-B0234S
-
E1-<sup>13sup>C3; Oestrone-<sup>13sup>C3
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
Estrone- 13C3 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
|
-
- HY-40354S
-
Tasocitinib-<sup>13sup>C3; CP-690550-<sup>13sup>C3
|
JAK
Apoptosis
|
Inflammation/Immunology
Cancer
|
Tofacitinib- 13C3 is the 13C-labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
|
-
- HY-N0623S2
-
-
- HY-N0623S8
-
Tryptophan-<sup>15sup>N2; Tryptophane-<sup>15sup>N2
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Tryptophan- 15N2 is the 15N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
|
-
- HY-B0150S2
-
Niacinamide-<sup>13sup>C6; Nicotinic acid amide-<sup>13sup>C6
|
Endogenous Metabolite
Sirtuin
|
Neurological Disease
Cancer
|
Nicotinamide- 13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
|
-
- HY-B0234S3
-
E1-<sup>13sup>C2; Oestrone-<sup>13sup>C2
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
Estrone- 13C2 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
|
-
- HY-B0213S1
-
Sulfametoxydiazine-<sup>13sup>C6; 5-Methoxysulfadiazine-<sup>13sup>C6
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
Sulfameter- 13C6 is the 13C6 labeled Sulfameter. Sulfameter (Sulfametoxydiazine; 5-Methoxysulfadiazine) is an effective long-acting sulfonamide antibiotic with antibacterial activities. Sulfameter can be used for the research of urinary tract infections and lepriasis.
|
-
- HY-B1331S1
-
Cyromazin-<sup>13sup>C3; CGA-72662-<sup>13sup>C3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
|
Cyromazine- 13C3 is the 13C3 labeled Cyromazine. Cyromazine is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects.
|
-
- HY-B0158S1
-
-
- HY-N0097S3
-
DL-Guanosine-<sup>15sup>N5; Vernine-<sup>15sup>N5
|
HSV
Endogenous Metabolite
|
Infection
|
Guanosine- 15N5 is the 15N labeled Guanosine[1]. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity[2].
|
-
- HY-N0378S2
-
Mannitol-<sup>13sup>C6; Mannite-<sup>13sup>C6
|
Apoptosis
Endogenous Metabolite
|
|
D-Mannitol- 13C6 is the 13C labeled D-Mannitol[1]. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator[2][3][4].
|
-
- HY-D0187S4
-
GSH-<sup>13sup>C; γ-L-Glutamyl-L-cysteinyl-glycine-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Others
|
L-Glutathione reduced- 13C (GSH- 13C; γ-L-Glutamyl-L-cysteinyl-glycine- 13C) is 13C-labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced is an endogenous antioxidant and oxygen free radical scavenger.
|
-
- HY-D0187S6
-
GSH-<sup>15sup>N; γ-L-Glutamyl-L-cysteinyl-glycine-<sup>15sup>N
|
Isotope-Labeled Compounds
|
Others
|
L-Glutathione reduced- 15N (GSH- 15N; γ-L-Glutamyl-L-cysteinyl-glycine- 15N) is 15N-labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant that scavenges oxygen free radicals.
|
-
- HY-N1150S11
-
DThyd-<sup>13sup>C10; NSC 21548-<sup>13sup>C10
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
Orthopoxvirus
|
Cancer
|
Thymidine- 13C10 (DThyd- 13C10; NSC 21548- 13C10) is 13C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
|
-
- HY-100196S1
-
PQQ-<sup>13sup>C3 sodium; Methoxatin-<sup>13sup>C3 sodium
|
Endogenous Metabolite
|
Inflammation/Immunology
|
Pyrroloquinoline quinone-13C3 (sodium) is an isotope of Pyrroloquinoline quinone. Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .
|
-
- HY-N0097S4
-
DL-Guanosine-<sup>13sup>C10; Vernine-<sup>13sup>C10
|
Isotope-Labeled Compounds
Endogenous Metabolite
HSV
|
Infection
|
Guanosine- 13C10 is the 13C labeled Guanosine (HY-N0097). Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .
|
-
- HY-Y0589S
-
3-Carboxybenzonitrile-<sup>13sup>C6; 3-Cyanobenzoic acid-<sup>13sup>C6; m-Carboxybenzonitrile-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Others
|
m-Cyanobenzoic acid- 13C6 is the 13C labeled m-Cyanobenzoic acid[1].
|
-
- HY-13756S
-
FK506-<sup>13sup>C,d2; Fujimycin-<sup>13sup>C,d2; FR900506-<sup>13sup>C,d2
|
Phosphatase
FKBP
Bacterial
Autophagy
Antibiotic
|
Infection
Inflammation/Immunology
Cancer
|
Tacrolimus- 13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].
|
-
- HY-B0389S18
-
Glucose-<sup>13sup>C3-1; D-(+)-Glucose-<sup>13sup>C3-1; Dextrose-<sup>13sup>C3-1
|
Endogenous Metabolite
|
Metabolic Disease
|
D-Glucose- 13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-B0389S15
-
Glucose-<sup>13sup>C2-4; D-(+)-Glucose-<sup>13sup>C2-4; Dextrose-<sup>13sup>C2-4
|
Endogenous Metabolite
|
Metabolic Disease
|
D-Glucose- 13C2-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-B0389S9
-
Glucose-<sup>13sup>C3-2; D-(+)-Glucose-<sup>13sup>C3-2; Dextrose-<sup>13sup>C3-2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
D-Glucose- 13C3-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-14855S
-
TR 700-<sup>13sup>C,d3; Torezolid-<sup>13sup>C,d3; DA-7157-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Tedizolid- 13C,d3 is the 13C- and deuterium labeled Tedizolid. Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome.
|
-
- HY-B0457S2
-
Chlorimipramine-<sup>13sup>C,d3 hydrochloride; G-34586-<sup>13sup>C,d3 hydrochloride; NSC-169865-<sup>13sup>C,d3 hydrochloride
|
Isotope-Labeled Compounds
Serotonin Transporter
|
Neurological Disease
|
Clomipramine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
|
-
- HY-B0389S21
-
Glucose-<sup>13sup>C,d2; D-(+)-Glucose-<sup>13sup>C,d2; Dextrose-<sup>13sup>C,d2
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
D-Glucose- 13C,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
|
-
- HY-B0389S25
-
Glucose-<sup>13sup>C,d1; D-(+)-Glucose-<sup>13sup>C,d1; Dextrose-<sup>13sup>C,d1
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
|
-
- HY-Y1298S
-
Acetoacetate methyl ester-<sup>13sup>C4; Methyl 3-oxobutanoate-<sup>13sup>C4; Methyl acetoacetate-<sup>13sup>C4
|
Endogenous Metabolite
|
Others
|
Methyl acetylacetate- 13C4 is an isotopically labeled compound. Methyl acetylacetate- 13C4 can be used for various biochemical studies[1].
|
-
- HY-N1393S
-
NSC 3778-<sup>13sup>C6; O-Methylsalicylic acid-<sup>13sup>C6; Salicylic acid methyl ether-<sup>13sup>C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
2-Methoxybenzoic acid- 13C6 is the 13C-labeled 2-Methoxybenzoic acid. 2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.
|
-
- HY-A0042S1
-
CGP 33101-<sup>15sup>N,d2; E 2080-<sup>15sup>N,d2; RUF 331-<sup>15sup>N,d2
|
Isotope-Labeled Compounds
|
Neurological Disease
|
Rufinamide- 15N,d2 is the deuterium and 15N labeled Rufinamide[1]. Rufinamide is a new antiepileptic agent that differs structurally from other antiepileptic agents and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS)[2][3].
|
-
- HY-N0098S2
-
p-Vanillin-<sup>13sup>C6; m-Methoxy-p-hydroxybenzaldehyde-<sup>13sup>C6; p-Hydroxy-m-methoxybenzaldehyde-<sup>13sup>C6
|
Endogenous Metabolite
|
Others
|
Vanillin- 13C6 is the 13C labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
|
-
- HY-B1511S
-
Cyclic adenosine monophosphate-<sup>13sup>C5; Adenosine cyclic 3', 5'-monophosphate-<sup>13sup>C5; cAMP-<sup>13sup>C5
|
Isotope-Labeled Compounds
|
Others
|
Cyclic AMP- 13C5 is a deuterated cyclic AMP.
|
-
- HY-16561S1
-
trans-Resveratrol-<sup>13sup>C6; SRT501-<sup>13sup>C6
|
Isotope-Labeled Compounds
IKK
Autophagy
Mitophagy
Sirtuin
Apoptosis
Bacterial
Fungal
Antibiotic
Keap1-Nrf2
|
Infection
Inflammation/Immunology
Cancer
|
Resveratrol- 13C6 is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].
|
-
- HY-113294S
-
3-Hydroxy-DL-kynurenine-<sup>13sup>C3,<sup>15sup>N
|
Isotope-Labeled Compounds
|
Others
|
3-Hydroxykynurenine- 13C3, 15N (3-Hydroxy-DL-kynurenine- 13C3, 15N)is the 13C and 15N labeled3-Hydroxykynurenine(HY-113294) . 3-Hydroxykynurenine, a?metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis .
|
-
- HY-18341S1
-
-
- HY-N0650S
-
(-)-Serine-<sup>13sup>C3; (S)-Serine-<sup>13sup>C3
|
Endogenous Metabolite
|
Cancer
|
L-Serine- 13C3 is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-N0229S10
-
-
- HY-N0682S3
-
Pyridoxol-<sup>13sup>C4 hydrochloride; Vitamin B6-<sup>13sup>C4 hydrochloride
|
Isotope-Labeled Compounds
Endogenous Metabolite
Keap1-Nrf2
|
Neurological Disease
|
Pyridoxine- 13C4 (hydrochloride) is the 13C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
|
-
- HY-N0229S15
-
L-2-Aminopropionic acid-<sup>13sup>C2,<sup>15sup>N
|
Endogenous Metabolite
|
|
L-Alanine- 13C2, 15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-N0091S2
-
-
- HY-N0684S3
-
Phylloquinone-<sup>13sup>C6; Phytomenadione-<sup>13sup>C6
|
Endogenous Metabolite
|
Cardiovascular Disease
|
Vitamin K1- 13C6 is the 13C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
|
-
- HY-B0495S4
-
LTG-<sup>13sup>C3; BW430C-<sup>13sup>C3
|
Sodium Channel
Autophagy
|
Neurological Disease
|
Lamotrigine- 13C3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
|
-
- HY-15398S4
-
Cholecalciferol-<sup>13sup>C5; Colecalciferol-<sup>13sup>C5
|
Bacterial
VD/VDR
|
Infection
Endocrinology
|
Vitamin D3- 13C5 is the deuterium labeled Vitamin D3 (HY-15398). Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells[1][2].
|
-
- HY-13613S
-
GG 745-<sup>13sup>C6; GI 198745-<sup>13sup>C6
|
Apoptosis
5 alpha Reductase
|
Cancer
|
Dutasteride- 13C6 is the 13C labeled Dutasteride[1]. Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT[2].
|
-
- HY-19821S1
-
Fmoc-L-isoleucine-<sup>13sup>C6,<sup>15sup>N
|
Isotope-Labeled Compounds
|
Others
|
Fmoc-Ile-OH- 13C6, 15N is the 13C and 15N labeled Fmoc-Ile-OH[1]. Fmoc-Ile-OH is an isoleucine derivative[2].
|
-
- HY-B0228S1
-
Adenine riboside-<sup>13sup>C5; D-Adenosine-<sup>13sup>C5
|
Apoptosis
Nucleoside Antimetabolite/Analog
Autophagy
Endogenous Metabolite
|
|
Adenosine- 13C5 is the 13C labeled Adenosine[1]. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[2][3].
|
-
- HY-B0400S16
-
Sorbitol-<sup>13sup>C6; D-Glucitol-<sup>13sup>C6
|
Bacterial
Endogenous Metabolite
|
Others
|
D-Sorbitol- 13C6 is the 13C labeled D-Sorbitol[1]. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[2].
|
-
- HY-N0091S7
-
Purin-6-ol-<sup>15sup>N4; Sarcine-<sup>15sup>N4
|
Endogenous Metabolite
|
Others
|
Hypoxanthine- 15N4 is the 15N labeled Hypoxanthine[1]. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia[2].
|
-
- HY-B0228S11
-
Adenine riboside-<sup>15sup>N5; D-Adenosine-<sup>15sup>N5
|
Isotope-Labeled Compounds
|
Cancer
|
Adenosine- 15N5 (Adenine riboside- 15N5; D-Adenosine- 15N5) is the 15N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .
|
-
- HY-N7745S2
-
Glucopsychosine-<sup>13sup>C6; Lyso-Gb1-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Others
|
Glucosylsphingosine- 13C6 is an active compound. Glucosylsphingosine- 13C6 can be used for various studies .
|
-
- HY-17563S2
-
Deoxyguanosine-<sup>13sup>C10; Guanine deoxyriboside-<sup>13sup>C10
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
2'-Deoxyguanosine- 13C10 (Deoxyguanosine- 13C10; Guanine deoxyriboside- 13C10) is 13C-labeled 2'-Deoxyguanosine (HY-17563). 2'-Deoxyguanosine (Deoxyguanosine) is deoxyguanosine.
|
-
- HY-17563S4
-
Deoxyguanosine-<sup>15sup>N5; Guanine deoxyriboside-<sup>15sup>N5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
2'-Deoxyguanosine- 15N5 (Deoxyguanosine- 15N5; Guanine deoxyriboside- 15N5) is 15N labeled 2'-Deoxyguanosine (HY-17563). 2'-Deoxyguanosine (Deoxyguanosine) is deoxyguanosine.
|
-
- HY-B0228S13
-
-
- HY-B1028S
-
D-Pantethine-<sup>15sup>N2; LBF disulfide-<sup>15sup>N2
|
Isotope-Labeled Compounds
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Endocrinology
Cancer
|
Pantethine- 15N2 is the 15N2 labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration [5] .
|
-
- HY-A0084S1
-
Procaine amide-<sup>13sup>C2 hydrochloride; SP 100-<sup>13sup>C2 hydrochloride
|
Isotope-Labeled Compounds
|
Cancer
|
Procainamide- 13C2 hydrochloride is 13C labeled Procainamide. Procainamide hydrochloride is an antiarrhythmic agent used in the study of cardiac arrhythmias.
|
-
- HY-B0504S1
-
NSC13123-<sup>13sup>C
|
Endogenous Metabolite
|
Metabolic Disease
|
Creatinine- 13C is the 13C-labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.
|
-
- HY-76847S2
-
-
- HY-N1420AS
-
L-Rhamnose-<sup>13sup>C monohydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
Rhamnose- 13C (monohydrate) is the 13C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate c
|
-
- HY-B2227BS2
-
Lactic acid-<sup>13sup>C sodium
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Lactate- 13C (sodium) is the 13C labeled Lactate sodium[1]. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium functions in a variety of biochemical processes[2].
|
-
- HY-W096993S1
-
Tetrapropylammonium bromide-<sup>15sup>N
|
Isotope-Labeled Compounds
|
Others
|
TPABr (Tetrapropylammonium bromide)- 15N is the 15N labeled TPABr (Tetrapropylammonium bromide) .
|
-
- HY-133968S1
-
Ostreasterol-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Others
|
24-Methylenecholesterol- 13C (Ostreasterol- 13C)is the 13C labeled24-Methylenecholesterol(HY-133968) . 24-Methylenecholesterol (Ostreasterol), a natural marine sterol, stimulates cholesterol acyltransferase in human macrophages. 24-Methylenecholesterol possess anti-aging effects in yeast. 24-methylenecholesterol enhances honey bee longevity and improves nurse bee physiology .
|
-
- HY-B0892S5
-
-
- HY-126050S
-
Pantetheine-<sup>15sup>N
|
Isotope-Labeled Compounds
|
Others
|
(R)-Pantetheine- 15N (Pantetheine- 15N) is the 15N labeled (R)-Pantetheine (HY-126050). (R)-Pantetheine is the biosynthetic precursor to CoA .
|
-
- HY-W768338
-
D-(+)-Saccharose-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
Sucrose- 13C is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .
|
-
- HY-B0445S1
-
β-DPN-<sup>13sup>C5; β-NAD-<sup>13sup>C5; β-Nicotinamide Adenine Dinucleotide-<sup>13sup>C5
|
Endogenous Metabolite
|
Metabolic Disease
|
NAD+- 13C5-1 is the 13C labeled NAD+[1]. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
|
-
- HY-141939S
-
L-Liothyronine-<sup>13sup>C6; T3-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Others
|
Triiodothyronine- 13C6 (hydrochloride) is the 13C labeled Triiodothyronine[1].
|
-
- HY-B0456S2
-
Vitamin B2-<sup>13sup>C5; E101-<sup>13sup>C5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Riboflavin- 13C5 is the 13C-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-W011240S
-
Methforylthiazidine-<sup>13sup>C,d2; Rontyl-<sup>13sup>C,d2
|
Isotope-Labeled Compounds
|
Others
|
Hydroflumethiazide- 13C,d2 is the deuterium and 13C labeled Hydroflumethiazide[1].
|
-
- HY-W013812S
-
Linoleic acid-<sup>13sup>C18 ethyl ester; Mandenol-<sup>13sup>C18
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
Ethyl linoleate- 13C18 is the 13C labeled Ethyl linoleate. Ethyl linoleate inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators[1].
|
-
- HY-B0143S3
-
-
- HY-B0216S2
-
-
- HY-N0680S3
-
-
- HY-A0181S
-
AMP-<sup>13sup>C10,<sup>15sup>N5
|
Endogenous Metabolite
|
Metabolic Disease
|
Adenosine monophosphate- 13C10, 15N5 is the 13C-labeled and 15N-labeled Adenosine monophosphate. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction[1].
|
-
- HY-Y0978S2
-
N-tert-Butoxycarbonyl-2-aminoacetic acid-2-<sup>13sup>C; NSC 127669-2-<sup>13sup>C
|
Isotope-Labeled Compounds
Androgen Receptor
|
Endocrinology
|
Boc-Glycine-2- 13C is a 13C-labeled Linuron. Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive a
|
-
- HY-B0688S2
-
4,4′-Diaminodiphenyl sulfone-<sup>13sup>C12; DDS-<sup>13sup>C12
|
Isotope-Labeled Compounds
Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
|
Dapsone- 13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al [5].
|
-
- HY-10163S2
-
BIBR 953-<sup>13sup>C6; BIBR 953ZW-<sup>13sup>C6
|
Thrombin
|
|
Dabigatran- 13C6 is the 13C labeled Dabigatran[1]. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[2][3].
|
-
- HY-N0304S1
-
Levodopa-<sup>13sup>C6; 3,4-Dihydroxyphenylalanine-<sup>13sup>C6
|
Dopamine Receptor
Endogenous Metabolite
|
|
L-DOPA- 13C6 is the 13C-labled L-DOPA . L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .
|
-
- HY-N0543S
-
5-Ureidohydantoin-<sup>13sup>C2,<sup>15sup>N4
|
Imidazoline Receptor
Endogenous Metabolite
|
|
Allantoin- 13C2, 15N4 is the 13C and 15N labeled Allantoin[1]. Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth[2].
|
-
- HY-W040055S
-
D-(+)-Neopterin-<sup>13sup>C5; D-erythro-Neopterin-<sup>13sup>C5
|
Isotope-Labeled Compounds
|
Others
|
Neopterin- 13C5 (D-(+)-Neopterin- 13C5; D-erythro-Neopterin- 13C5)is the deuterium labeledNeopterin(HY-W040055) . Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation .
|
-
- HY-14605S
-
(R)-AGN1135-<sup>13sup>C3 mesylate; TVP1012-<sup>13sup>C3 mesylate
|
Isotope-Labeled Compounds
|
Others
|
Rasagiline- 13C3 ((R)-AGN1135- 13C3; TVP1012- 13C3) mesylateis the deuterium labeledRasagiline (mesylate)(HY-14605) . Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43?nM and 412?nM for rat brain MAO B and A activity, respectively .
|
-
- HY-13078S
-
GDC-0973-<sup>13sup>C66 racemate; XL518-<sup>13sup>C6 racemate
|
Isotope-Labeled Compounds
|
Others
|
Cobimetinib- 13C6 (GDC-0973- 13C6; XL518- 13C6) racemateis the deuterium labeledCobimetinib (racemate)(HY-13078) . Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor .
|
-
- HY-B0152S3
-
6-Aminopurine-<sup>13sup>C5; Vitamin B4-<sup>13sup>C5
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
Adenine- 13C5 (6-Aminopurine- 13C5; Vitamin B4- 13C5) is 13C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA.
Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
|
-
- HY-B0152S4
-
6-Aminopurine-<sup>15sup>N5; Vitamin B4-<sup>15sup>N5
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
Adenine- 15N5 (6-Aminopurine- 15N5; Vitamin B4- 15N5) is 15N labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA.
Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
|
-
- HY-111095S2
-
(R)-2-Hydroxypropionic acid-<sup>13sup>C-1; D-Lactic acid-<sup>13sup>C-1
|
Endogenous Metabolite
|
Others
|
D-(-)-Lactic acid- 13C-1 is the 13C labeled D-(-)-Lactic acid. D-(-)-Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. D-(-)-Lactic acid is identified to be a competitive inhibitor of ProDH (proline dehydrogenase) in plants .
|
-
- HY-111095S3A
-
(R)-2-Hydroxypropionic acid-<sup>13sup>C-2 sodium; D-Lactic acid-<sup>13sup>C-2 sodium
|
Isotope-Labeled Compounds
|
Others
|
D-(-)-Lactic acid-13C-2 (sodium) is a sodium. D-(-)-Lactic acid-13C-2 (sodium) can be used for a variety of biochemical studies.
|
-
- HY-12956S2
-
Prostaglandin F2α-<sup>13sup>C5; PGF2α-<sup>13sup>C5
|
Prostaglandin Receptor
Endogenous Metabolite
Autophagy
Apoptosis
Isotope-Labeled Compounds
|
Endocrinology
|
Dinoprost- 13C5 is 13C labeled Dinoprost (HY-12956). Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
|
-
- HY-112499S1
-
Vitamin K2-7-<sup>13sup>C6; Vitamin K2(35)-<sup>13sup>C6; Vitamin MK-7-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
Menaquinone-7- 13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].
|
-
- HY-108213S1
-
5'-IMP<sup>15sup>N4 dilithium; IMP-<sup>15sup>N4 dilithium; Inosine 5'-dihydrogen phosphate-<sup>15sup>N4 dilithium
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Inosinic acid- 15N4 dilithium (5'-IMP-15N4 (dilithium); IMP-15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-15N4 (dilithium)) is 15N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .
|
-
- HY-13318S1
-
GS 4071-<sup>13sup>C,d3; Ro 64-0802-<sup>13sup>C,d3; Oseltamivir carboxylate-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Drug Metabolite
Influenza Virus
|
Infection
|
Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC50=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections [5].
|
-
- HY-Y0921S3
-
1,2-(RS)-Propanediol-<sup>13sup>C3; 1,2-Propylene glycol-<sup>13sup>C3; Propylene glycol-<sup>13sup>C3
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Neurological Disease
|
(±)-1,2-Propanediol- 13C3 is 13C labeled (±)-1,2-Propanediol (HY-Y0921). (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish .
|
-
- HY-110261
-
|
IKK
E1/E2/E3 Enzyme
NF-κB
|
Inflammation/Immunology
|
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCF βTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect .
|
-
- HY-144731
-
|
HIV
|
Inflammation/Immunology
|
gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC50 of 7.5 µM and CC50 of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells .
|
-
- HY-P1604
-
|
Sodium Channel
|
Inflammation/Immunology
|
ATX-II is a specific Na + channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na +sup channel in cell cultures. ATX-II sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation .
|
-
- HY-N1415S1
-
(-)-(E)-Caryophyllene-<sup>13sup>C,d2; (−)-β-caryophyllene-<sup>13sup>C,d2; (−)-trans-Caryophyllene-<sup>13sup>C,d2
|
Endogenous Metabolite
Cannabinoid Receptor
Isotope-Labeled Compounds
|
Cancer
|
β-Caryophyllene- 13C,d2 is 13C and deuterated labeled trans,trans-2,4-Decadienal (HY-W013627). trans,trans-2,4-Decadienal is a lipid peroxidation product of linolieic acid .
|
-
- HY-14605BS
-
AGN1135-<sup>13sup>C3; TVP1012-<sup>13sup>C3 racemic
|
Isotope-Labeled Compounds
Monoamine Oxidase
|
Neurological Disease
|
Rasagiline- 13C3 (mesylate racemic) is a 13C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1]. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-90001S1
-
ABT 538-<sup>13sup>C,d3; RTV-<sup>13sup>C,d3
|
HIV Protease
HIV
SARS-CoV
Apoptosis
|
Infection
|
Ritonavir- 13C,d3 is the 13C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
|
-
- HY-B0891S1
-
17-Hydroxyprogesterone-<sup>13sup>C3; 17-OHP-<sup>13sup>C3
|
Progesterone Receptor
Endogenous Metabolite
|
Others
|
17α-Hydroxyprogesterone- 13C3 is the 13C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
|
-
- HY-16637S3
-
-
- HY-N0215S11
-
(S)-2-Amino-3-phenylpropionic acid-<sup>13sup>C9,<sup>15sup>N
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
L-Phenylalanine- 13C9, 15N is the 13C- and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0455AS8
-
(S)-(+)-Arginine-<sup>13sup>C6,<sup>15sup>N4 hydrochloride
|
NO Synthase
Endogenous Metabolite
|
Others
|
L-Arginine- 13C6, 15N4 (hydrochloride) is the 13C- and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-12033S1
-
2-ME2-<sup>13sup>C6; NSC-659853-<sup>13sup>C6
|
Isotope-Labeled Compounds
Microtubule/Tubulin
Reactive Oxygen Species
Apoptosis
Autophagy
Endogenous Metabolite
|
Cancer
|
2-Methoxyestradiol- 13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].
|
-
- HY-B0166S
-
-
- HY-100427S
-
CL29926-<sup>13sup>C,d3; (±)-Imazamox-<sup>13sup>C,d3
|
Acetolactate Synthase (ALS)
Isotope-Labeled Compounds
|
Others
|
Imazamox- 13C,d3 is the 13C- and deuterium labeled Imazamox. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death[1][2].
|
-
- HY-17034AS
-
(+)-Medetomidine-<sup>13sup>C,d3 hydrochloride; (S)-Medetomidine-<sup>13sup>C,d3 hydrochloride
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Neurological Disease
Endocrinology
Cancer
|
Dexmedetomidine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].
|
-
- HY-B0508S1
-
-
- HY-A0132S8
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>13sup>C,<sup>15sup>N
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 13C, 15N is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-B0158S2
-
-
- HY-N0378S6
-
-
- HY-15772S1
-
AZD-9291-<sup>13sup>C,d3; Mereletinib-<sup>13sup>C,d3
|
EGFR
|
Cancer
|
Osimertinib- 13C,d3 is the deuterium and 13C labeled Osimertinib. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively.
|
-
- HY-13690S1
-
2,4′-DDD-<sup>13sup>C6; o,p'-DDD-<sup>13sup>C6
|
Apoptosis
|
Cancer
|
Mitotane- 13C6 is the 13C labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].
|
-
- HY-90006S3
-
5-FU-<sup>13sup>C4,<sup>15sup>N2
|
Apoptosis
Nucleoside Antimetabolite/Analog
HIV
Endogenous Metabolite
|
Cancer
|
5-Fluorouracil- 13C4, 15N2 is the 13C and 15N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].
|
-
- HY-B2176S
-
Adenosine 5'-triphosphate-<sup>13sup>C10,<sup>15sup>N5
|
Endogenous Metabolite
|
|
ATP- 13C10, 15N5 is the 13C and 15N labeled ATP[1]. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[2][3].
|
-
- HY-W012926S
-
5,6-Dihydrouracil-<sup>13sup>C4,<sup>15sup>N2
|
Endogenous Metabolite
|
Metabolic Disease
|
Dihydrouracil- 13C4, 15N2 is the 13C and 15N labeled Dihydrouracil[1]. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].
|
-
- HY-103447S1
-
Mycotoxin F2-<sup>13sup>C18; Toxin F2-<sup>13sup>C18
|
Isotope-Labeled Compounds
|
Others
|
Zearalenone- 13C18 (Mycotoxin F2- 13C18; Toxin F2- 13C18) is the 13C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
|
-
- HY-10219S1
-
Sirolimus-<sup>13sup>C,d3; AY-22989-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
|
Others
|
Rapamycin- 13C,d3 (Sirolimus- 13C,d3; AY-22989- 13C,d3) is the 13C and deuterium labeled Rapamycin (HY-10219) . Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .
|
-
- HY-B1342S3
-
Vitamin A1-<sup>13sup>C3; all-trans-Retinol-<sup>13sup>C3
|
Isotope-Labeled Compounds
|
Others
|
Retinol- 13C3 (Vitamin A1- 13C3; all-trans-Retinol- 13C3) is a 13C-labeled Vitamin A/Retinol (HY-B1342). Retinol is an endogenous metabolite.
|
-
- HY-N0086S2
-
6-Methyladenosine-<sup>13sup>C4; N-Methyladenosine-<sup>13sup>C4
|
Isotope-Labeled Compounds
Influenza Virus
Endogenous Metabolite
|
Infection
|
N6-Methyladenosine- 13C4 (6-Methyladenosine- 13C4; N-Methyladenosine- 13C4) is 13C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.
|
-
- HY-W008642S
-
L-Leucyl-<sup>13sup>C6,<sup>15sup>N-L-leucine
|
Isotope-Labeled Compounds
|
Others
|
(Leu-13C6,15N)-Leu-OH TFA is a C13 and N15 labeled Leu-Leu-OH TFA. Leu-Leu-OH, a Leu derivative, is a dipeptide .
|
-
- HY-W269700S
-
L-Isoleucyl-L-leucine-<sup>13sup>C6,<sup>15sup>N
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Ile-(Leu-13C6,15N)-OH (TFA) is 13C- and 15N-labeled L-Isoleucyl-L-leucine (HY-W269700). L-Isoleucyl-L-leucine has a role as a metabolite and can be used to inhibit movement-induced muscle damage and muscle defective condition.
|
-
- HY-N0086S3
-
6-Methyladenosine-<sup>13sup>C3; N-Methyladenosine-<sup>13sup>C3
|
Isotope-Labeled Compounds
Influenza Virus
Endogenous Metabolite
|
Infection
|
N6-Methyladenosine- 13C3 (6-Methyladenosine- 13C3) is 13C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities .
|
-
- HY-W751165
-
-
- HY-13632S5
-
FCE 24304-<sup>13sup>C,d2; EXE-<sup>13sup>C,d2
|
Cytochrome P450
Isotope-Labeled Compounds
|
Endocrinology
Cancer
|
Exemestane- 13C,d2 is 13C and deuterated labeled Exemestane (HY-13632). Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
|
-
- HY-B0252S3
-
HCTZ-<sup>15sup>N2,<sup>13sup>C,d2
|
Potassium Channel
TGF-beta/Smad
Isotope-Labeled Compounds
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
Hydrochlorothiazide- 15N2, 13C,d2 is 15N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
- HY-41417S3
-
Caprylic acid-<sup>13sup>C
|
Endogenous Metabolite
|
Metabolic Disease
|
Octanoic acid- 13C is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-N7092S1
-
-
- HY-N0455AS7
-
(S)-(+)-Arginine-<sup>13sup>C hydrochloride
|
NO Synthase
Endogenous Metabolite
|
Others
|
L-Arginine- 13C (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-W004260S3
-
Icosanoic acid-<sup>13sup>C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
Arachidic acid- 13C is the 13C labeled Arachidic acid. Arachidic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue .
|
-
- HY-77956S1
-
Deoxyribose-<sup>13sup>C-1
|
Endogenous Metabolite
|
Others
|
Thyminose- 13C-1 is the 13C labeled Thyminose. Thyminose is an endogenous metabolite[1].
|
-
- HY-77956S2
-
Deoxyribose-<sup>13sup>C-2
|
Endogenous Metabolite
|
Others
|
Thyminose- 13C-2 is the 13C labeled Thyminose. Thyminose is an endogenous metabolite[1].
|
-
- HY-B1449S1
-
-
- HY-N0538S
-
-
- HY-N0538S1
-
-
- HY-N0538S2
-
-
- HY-W010042S
-
L-(-)-Glucose-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
L-Glucose- 13C is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake[1][2].
|
-
- HY-42680S
-
D-(-)-Tagatose-<sup>13sup>C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
D-Tagatose- 13C is the 13C labeled D-Tagatose. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice
|
-
- HY-B1659S2
-
-
- HY-N0210S
-
-
- HY-W012835S2
-
4-Methoxytoluene-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Others
|
4-Methylanisole- 13C is the 13C-labeled 4-Methylanisole. 4-Methylanisole (4-Methoxytoluene) is food flavoring agent and can be naturally found in Ylang Ylang fragrance oil[1].
|
-
- HY-Y0781S1
-
Acetylformic acid-<sup>13sup>C
|
Endogenous Metabolite
|
Others
|
Pyruvic acid- 13C is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
|
-
- HY-Y0827S
-
-
- HY-15236S
-
RO-2433-<sup>13sup>C,d3; GS-331007-<sup>13sup>C,d3; Sofosbuvir metabolite GS-331007-<sup>13sup>C,d3
|
HCV
|
Infection
|
PSI-6206- 13C,d3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
|
-
- HY-16938S
-
-(Methylthio)-5'-deoxyadenosine-<sup>13sup>C6; 5'-Deoxy-5'-(methylthio)adenosine-<sup>13sup>C6; 5'-S-Methyl-5'-thioadenosine-<sup>13sup>C6
|
Endogenous Metabolite
Apoptosis
|
Metabolic Disease
Cancer
|
5'-Methylthioadenosine- 13C6 is the 13C-labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].
|
-
- HY-113038AS
-
2-Hydroxyglutarate-<sup>13sup>C5 disodium; 2-Hydroxyglutaric acid-<sup>13sup>C5 sodium; 2-Hydroxypentanedioic acid-<sup>13sup>C5 disodium
|
Histone Demethylase
Endogenous Metabolite
|
Cancer
|
α-Hydroxyglutaric acid- 13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].
|
-
- HY-N0098S
-
p-Vanillin-<sup>13sup>C,d3; m-Methoxy-p-hydroxybenzaldehyde-<sup>13sup>C,d3; p-Hydroxy-m-methoxybenzaldehyde-<sup>13sup>C,d3
|
Endogenous Metabolite
|
Others
|
Vanillin- 13C,d3 is the 13C and deuterium labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
|
-
- HY-10241S
-
TMC435-<sup>13sup>C,d3; TMC435350-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
HCV
HCV Protease
SARS-CoV
DNA/RNA Synthesis
|
Infection
|
Simeprevir- 13C,d3 is the 13C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].
|
-
- HY-N1394S
-
-
- HY-113008AS
-
(Z)-Urocanic acid-<sup>13sup>C3; cis-UCA-<sup>13sup>C3
|
Isotope-Labeled Compounds
5-HT Receptor
|
Inflammation/Immunology
|
cis-Urocanic acid- 13C3 is the 13C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1].
|
-
- HY-N0650S9
-
(-)-Serine-<sup>15sup>N,d3; (S)-Serine-<sup>15sup>N,d3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
L-Serine- 15N,d3 is the deuterium and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-N0717S2
-
-
- HY-N0717S3
-
-
- HY-W014423S3
-
H-His-OH-<sup>13sup>C6,<sup>15sup>N3 hydrochloride hydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
L-Histidine- 13C6, 15N3 (hydrochloride hydrate) is the 13C- and 15N-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-10999S2
-
GSK1120212-<sup>13sup>C,d3; JTP-74057-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
MEK
Autophagy
Apoptosis
|
Cancer
|
Trametinib- 13C,d3 is the 13C- and deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].
|
-
- HY-13683S1
-
RU486-<sup>13sup>C,d3; RU 38486-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Progesterone Receptor
Glucocorticoid Receptor
NO Synthase
Autophagy
|
Endocrinology
Cancer
|
Mifepristone- 13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-15321S1
-
MK-0663-<sup>13sup>C,d3; L-791456-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
Etoricoxib- 13C,d3 is the 13C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
|
-
- HY-B0002BS2
-
-
- HY-B0495S1
-
LTG-<sup>13sup>C,d3; BW430C-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Sodium Channel
Autophagy
|
Neurological Disease
|
Lamotrigine- 13C,d3 is the 13C- and deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
|
-
- HY-113225S1
-
-
- HY-128738S
-
TMP-<sup>13sup>C10,<sup>15sup>N2
|
Endogenous Metabolite
|
Metabolic Disease
|
Thymidine-5'-monophosphate- 13C10, 15N2 (disodium) is the 13C and 15N labeled Thymidine-5'-monophosphate disodium salt[1]. Thymidine-5'-monophosphate disodium salt is an endogenous metabolite.
|
-
- HY-18341S4
-
Levothyroxine-<sup>13sup>C6-1; T4-<sup>13sup>C6-1
|
Isotope-Labeled Compounds
|
Endocrinology
|
L-Thyroxine- 13C6-1 (Levothyroxine- 13C6-1; T4- 13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
|
-
- HY-A0181BS
-
AMP-<sup>13sup>C10,<sup>15sup>N5 disodium
|
Endogenous Metabolite
|
Infection
|
Adenosine monophosphate-13C10,15N5 (disodium) is the sodium salt form of Adenosine monophosphate-13C10,15N5. Adenosine monophosphate is a key cellular metabolite that regulates energy homeostasis and signal transduction .
|
-
- HY-16106S
-
BMN-673-<sup>13sup>C,d4; LT-673-<sup>13sup>C,d4
|
Isotope-Labeled Compounds
|
Others
|
Talazoparib- 13C,d4 is 13C and deuterated labeled Talazoparib (HY-16106). Talazoparib is an orally active PARP 1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM for inhibiting PARP1 and PARP2 enzymatic activities, respectively. Has anti-tumor activity.
|
-
- HY-W101298S
-
L-Leucyl-<sup>13sup>C6,<sup>15sup>N-L-isoleucine TFA
|
Isotope-Labeled Compounds
|
Neurological Disease
|
(Leu-13C6,15N)-Ile-OH (L-Leucyl-13C6,15N-L-isoleucine) TFA is the deuterium labeled Leu-Ile-OH. Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) synthesis .
|
-
- HY-B0250S1
-
BCH-189-<sup>13sup>C,<sup>15sup>N2,d2
|
Isotope-Labeled Compounds
HBV
Reverse Transcriptase
HIV
|
Infection
|
Lamivudine-13C,15N2,d2 (BCH-189-13C,15N2,d2) is a 13C, 15N, and deuterium labeled Lamivudine (HY-B0250). Lamivudine is an orally active and blood-brain barrier permeable nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus (HBV) reverse transcriptase .
|
-
- HY-19717S
-
S-[(1E)-1,2-Dichloroethenyl]-L-cysteine-<sup>13sup>C3,<sup>15sup>N
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
DCVC- 13C3, 15N is 15N and 13C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures .
|
-
- HY-B0445S
-
β-DPN-<sup>13sup>C5 ammonium; β-NAD-<sup>13sup>C5 ammonium; β-Nicotinamide Adenine Dinucleotide-<sup>13sup>C5 ammonium
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
NAD+-13C5 (ammonium) is the 13C labled NAD+ (HY-B0445), with an ammonium .
|
-
- HY-17427S2
-
BW1592-<sup>13sup>C,15sup>N2
|
Isotope-Labeled Compounds
|
Infection
|
Emtricitabine- 13C, 15N2 (BW1592- 13C, 15N2) is a 13C- and 15N-labeled Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.
|
-
- HY-15005S
-
PSI-7977-<sup>13sup>C,d3; GS-7977-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
HCV
|
Infection
|
Sofosbuvir- 13C,d3 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-N0390S6
-
L-Glutamic acid 5-amide-<sup>13sup>C5,<sup>15sup>N2
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine- 13C5, 15N2 is the 13C- and 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-10163S3
-
BIBR 953-<sup>13sup>C,d3; BIBR 953ZW-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Thrombin
|
Cardiovascular Disease
|
Dabigatran- 13C,d3 is the 13C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].
|
-
- HY-13629S1
-
-
- HY-14153AS
-
SDZ-HTF-919-<sup>13sup>C,d3; HTF-919-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
5-HT Receptor
|
Neurological Disease
Metabolic Disease
|
Tegaserod- 13C,d3 (maleate) is the 13C- and deuterium labeled Tegaserod (maleate). Tegaserod maleate is a selective 5-HT4 receptor partial agonist and a 5-HT2B receptor antagonist. Tegaserod maleate exhibits a promotile effect throughout the gastrointestinal (GI) tract[1][2][5].
|
-
- HY-B0957S
-
Erythromycin ethyl succinate-<sup>13sup>C,d3; EES-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Bacterial
HIV
Autophagy
Antibiotic
|
Infection
|
Erythromycin ethylsuccinate- 13C,d3 is the 13C- and deuterium labeled Erythromycin Ethylsuccinate. Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.
|
-
- HY-G0007S1
-
Omeprazole sulfone-<sup>13sup>C,d3; Omeprazole sulphone-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
Omeprazole metabolite Omeprazole sulfone- 13C,d3 is the deuterium and 13C labeled Omeprazole metabolite Omeprazole sulfone[1].
|
-
- HY-A0132S11
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>13sup>C,<sup>15sup>N-1
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 13C, 15N-1 is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-B2176S1
-
Adenosine 5'-triphosphate-<sup>13sup>C10,<sup>15sup>N5 disodium
|
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
ATP- 13C10, 15N5 (disodium) is a 13C-labeled and 15N-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[1][2][3][4].
|
-
- HY-Y1069S3
-
(S)-Hydroxybutanedioic acid-<sup>13sup>C4; (S)-E 296-<sup>13sup>C4
|
Isotope-Labeled Compounds
|
Others
|
(S)-Malic acid- 13C4 is the 13C labeled S-Malic acid (HY-Y1069)[1].
|
-
- HY-N0610AS2
-
3-Phenylacrylic acid-<sup>13sup>C3; β-Phenylacrylic acid-<sup>13sup>C3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
Cinnamic acid- 13C3 (3-Phenylacrylic acid- 13C3) is the 13C labeled Cinnamic acid (HY-N0610A). Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells .
|
-
- HY-18569S4
-
Indole-3-acetic acid-<sup>13sup>C6; 3-IAA-<sup>13sup>C6
|
Endogenous Metabolite
Molecular Glues
|
Others
|
3-Indoleacetic acid- 13C6 is the 13C labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.
|
-
- HY-W013159S
-
dGMP-<sup>13sup>C10,<sup>15sup>N5
|
Endogenous Metabolite
|
Metabolic Disease
|
2'-Deoxyguanosine 5'-monophosphate- 13C10, 15N5 (disodium) is the 13C and 15N labeled 2'-Deoxyguanosine 5'-monophosphate disodium[1]. 2'-Deoxyguanosine 5'-monophosphate disodium (5′-dGMP disodium) is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative[2].
|
-
- HY-W010918S1
-
Adenosine diphosphate-<sup>13sup>C10 dilithium; ADP-<sup>13sup>C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Adenosine 5'-diphosphate- 13C10 (Adenosine diphosphate- 13C10 dilithium; ADP- 13C10) dilithium is 13C-labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
|
-
- HY-W010918S2
-
Adenosine diphosphate-<sup>15sup>N5 dilithium; ADP-<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Adenosine 5'-diphosphate- 15N5 (Adenosine diphosphate- 15N5 dilithium; ADP- 15N5) dilithium is 15N labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
|
-
- HY-138615S4
-
-
- HY-B2236S2
-
(±)-2,6-Diaminocaproic acid-<sup>13sup>C6,<sup>15sup>N2 hydrochloride
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
DL-Lysine- 13C6, 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6, 15N2 hydrochloride) is 13C and 15N-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-113066S3
-
GDP-<sup>13sup>C10,<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
Potassium Channel
|
Inflammation/Immunology
|
Guanosine 5'-diphosphate- 13C10, 15N5 (GDP- 13C10, 15N5) dilithium is 13C and 15N-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
|
-
- HY-107372S2
-
UTP-<sup>13sup>C9 dilithium; Uridine 5'-triphosphate-<sup>13sup>C9 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
DNA/RNA Synthesis
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
Uridine triphosphate- 13C9 (UTP- 13C9 dilithium; Uridine 5'-triphosphate- 13C9) dilithium is 13C-labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
|
-
- HY-107372S4
-
UTP-<sup>15sup>N2 dilithium; Uridine 5'-triphosphate-<sup>15sup>N2 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
DNA/RNA Synthesis
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
Uridine triphosphate- 15N2 (UTP- 15N2 dilithium; Uridine 5'-triphosphate- 15N2) dilithium is 15N labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
|
-
- HY-Y0781S
-
Acetylformic acid-<sup>13sup>C (sodium)
|
Endogenous Metabolite
|
Others
|
Pyruvic acid- 13C (sodium) is the 13C-labeled Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
|
-
- HY-W014423S
-
H-His-OH-<sup>13sup>C hydrochloride hydrate
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Histidine- 13C (hydrochloride hydrate) is the 13C-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-W014423S6
-
-
- HY-W016562S3
-
2-Benzamidoacetic acid-<sup>15sup>N
|
Endogenous Metabolite
|
Metabolic Disease
|
Hippuric acid- 15N is the 15N-labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
|
-
- HY-113365S1
-
4-Cholesten-3-one-<sup>13sup>C
|
Endogenous Metabolite
|
|
Cholestenone- 13C is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2][3].
|
-
- HY-42682S1
-
D-Galactosamine-<sup>13sup>C (hydrochloride)
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
D(+)-Galactosamine- 13C (hydrochloride) is the 13C labeled D(+)-Galactosamine hydrochloride. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and
|
-
- HY-N1420AS2
-
L-Rhamnose-<sup>13sup>C-2 monohydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
Rhamnose- 13C-2 (monohydrate) is the 13C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate
|
-
- HY-B2227BS3
-
Lactic acid-<sup>13sup>C-1 sodium
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Lactate- 13C-1 (sodium) is the 13C labeled Lactate (sodium)[1]. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium functions in a variety of biochemical processes[2].
|
-
- HY-W088065S
-
-
- HY-113225S2
-
-
- HY-P1604A
-
|
Sodium Channel
|
Inflammation/Immunology
|
ATX-II TFA is a specific Na + channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na +sup channel in cell cultures. ATX-II TFA sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II TFA also induces pulmonary vein arrhythmogenesis and atrial fibrillation .
|
-
- HY-Y0045S
-
1-(1,3-Thiazol-2-yl)ethanone-<sup>13sup>C2; 1-(Thiazol-2-yl)ethanone-<sup>13sup>C2; Methyl 2-thiazolyl ketone-<sup>13sup>C2
|
Isotope-Labeled Compounds
|
Others
|
2-Acetylthiazole- 13C2 is 13C labeled Fructose-phenylalanine.
|
-
- HY-N0683S
-
-
- HY-B2156S1
-
Vitamin K2(MK-4)-<sup>13sup>C6; Menaquinone K4-<sup>13sup>C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
Menaquinone-4- 13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
|
-
- HY-N0683S1
-
-
- HY-N1446S2
-
-
- HY-101541S1
-
Methyl docosahexaenoate-<sup>13sup>C22; all cis-DHA methyl ester-<sup>13sup>C22
|
Isotope-Labeled Compounds
|
Others
|
Docosahexaenoic acid- 13C22 methyl ester is the 13C22 labeled Docosahexaenoic acid methyl ester (HY-101541)[1].
|
-
- HY-136648S
-
dATP-<sup>13sup>C10,<sup>15sup>N5 (tetraammonia)
|
Isotope-Labeled Compounds
|
Others
|
2'-Deoxyadenosine-5'-triphosphate- 13C10, 15N5 (tetraammonia) is the 13C10 ans 15N5 labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648)[1].
|
-
- HY-121259S
-
Adriamycinol-<sup>13sup>C,d3 TFA; DXR-OL-<sup>13sup>C,d3 TFA
|
Endogenous Metabolite
|
Others
|
Doxorubicinol- 13C,d3 (TFA) is the deuterium and 13C labeled Doxorubicinol TFA[1].
|
-
- HY-W013059S
-
DA-CE phosphoramidite-<sup>13sup>C10,<sup>15sup>N5
|
DNA/RNA Synthesis
|
Others
|
DMT-dA(bz) Phosphoramidite- 13C10, 15N5 is the 13C and 15N labeled DMT-dA(bz) Phosphoramidite[1]. DMT-dA(bz) Phosphoramidite is typically used in the synthesis of DNA[2].
|
-
- HY-W654078
-
BPAF-<sup>13sup>C12; 4,4'-(Perfluoropropane-2,2-diyl)diphenol-<sup>13sup>C12
|
Isotope-Labeled Compounds
|
Others
|
Bisphenol AF- 13C12 is an isotopic label of Bisphenol AF. Bisphenol AF is used in polycarbonate plastic and epoxy resin manufacturing. Bisphenol AF can significantly increase intracellular ROS levels .
|
-
- HY-Y0051S
-
2-Hydroxymethyl-5-furfural-<sup>13sup>C6; 2-Formyl-5-hydroxymethylfuran-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Others
|
5-Hydroxymethylfurfural- 13C6 (2-Hydroxymethyl-5-furfural- 13C6; 2-Formyl-5-hydroxymethylfuran- 13C6) is a 13C labeled 5-Hydroxymethylfurfural (HY-Y0051). 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
|
-
- HY-136648S1
-
dATP-<sup>13sup>C10,<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
DNA/RNA Synthesis
|
Others
|
2'-Deoxyadenosine-5'-triphosphate- 13C10, 15N5 (dATP- 13C10, 15N5) dilithium is 13C and 15N-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
|
-
- HY-125818S3
-
Cytidine triphosphate-<sup>13sup>C9 dilithium; 5'-CTP-<sup>13sup>C9 dilithium
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Infection
Cancer
|
Cytidine-5'-triphosphate- 13C9 (Cytidine triphosphate- 13C9 dilithium; 5'-CTP- 13C9) dilithium is 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
|
-
- HY-125818S6
-
Cytidine triphosphate-<sup>15sup>N3 dilithium; 5'-CTP-<sup>15sup>N3 dilithium
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Infection
Cancer
|
Cytidine-5'-triphosphate- 15N3 (Cytidine triphosphate- 15N3 dilithium; 5'-CTP- 15N3) dilithium is 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
|
-
- HY-101400S4
-
dCTP-<sup>13sup>C9 dilithium; 2′-Deoxycytidine-5′-triphosphate-<sup>13sup>C9 dilithium
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
Endogenous Metabolite
|
Metabolic Disease
|
Deoxycytidine triphosphate- 13C9 (dCTP- 13C9 dilithium; 2′-Deoxycytidine-5′-triphosphate- 13C9) dilithium is 13C-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
|
-
- HY-101400S3
-
dCTP-<sup>15sup>N3 dilithium; 2′-Deoxycytidine-5′-triphosphate-<sup>15sup>N3 dilithium
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
Endogenous Metabolite
|
Metabolic Disease
|
Deoxycytidine triphosphate- 15N3 (dCTP- 15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate- 15N3) dilithium is 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
|
-
- HY-138616S4
-
2'-Deoxyguanosine-5'-triphosphate-<sup>13sup>C10,<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
|
Infection
Cancer
|
dGTP- 13C10, 15N5 (2'-Deoxyguanosine-5'-triphosphate- 13C10, 15N5) dilithium is 13C and 15N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
|
-
- HY-W392933S4
-
Thymidine-5'-phosphate-<sup>13sup>C10,<sup>15sup>N2 dilithium
|
Isotope-Labeled Compounds
|
Others
|
Thymidine 5'-monophosphate- 13C10, 15N2 (Thymidine-5'-phosphate- 13C10, 15N2) dilithium is 13C and 15N-labeled Thymidine 5'-monophosphate (HY-W392933).
|
-
- HY-B0389S
-
-
- HY-Y1088S
-
3-Phenylpropionic acid-2,3-<sup>13sup>C2; 3-Phenylpropanoic acid-2,3-<sup>13sup>C2; 3-Phenyl-n-propionic acid-2,3-<sup>13sup>C2
|
Endogenous Metabolite
|
Others
|
Hydrocinnamic acid-2,3- 13C2 is the 13C-labeled Hydrocinnamic acid. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities.
|
-
- HY-B0389S22
-
Glucose-<sup>13sup>C2,d2; D-(+)-Glucose-<sup>13sup>C2,d2; Dextrose-<sup>13sup>C2,d2
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
D-Glucose- 13C2,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si
|
-
- HY-B0579S3
-
Cyclosporine A-<sup>13sup>C2,d4; Ciclosporin A-<sup>13sup>C2,d4; CsA-<sup>13sup>C2,d4
|
Isotope-Labeled Compounds
Calcineurin
|
Inflammation/Immunology
|
Cyclosporin A- 13C2,d4 (Cyclosporine A- 13C2,d4; Ciclosporin A- 13C2,d4) is a 13C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .
|
-
- HY-N0229S5
-
L-2-Aminopropionic acid-<sup>13sup>C3,<sup>15sup>N,d4
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
L-Alanine- 13C3, 15N,d4 is the deuterium, 13C-, and 15-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-A0132S9
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>13sup>C3,<sup>15sup>N
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 13C3, 15N is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-A0132S10
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>13sup>C2,<sup>15sup>N
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 13C2, 15N is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-B0158S6
-
Cytosine β-D-riboside-<sup>15sup>N3; Cytosine-1-β-D-ribofuranoside-<sup>15sup>N3
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Neurological Disease
|
Cytidine- 15N3 is the 15N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].
|
-
- HY-A0132S13
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>13sup>C8,<sup>15sup>N
|
Isotope-Labeled Compounds
|
Others
|
N-Acetyl-D-glucosamine- 13C8, 15N is 13C and 15N labeled N-Acetyl-D-glucosamine (HY-A0132). N-Acetyl-D-glucosamine is a monosaccharide derivative of glucose.
|
-
- HY-N5134S1
-
5'-GMP-<sup>13sup>C10 dilithium; 5'-guanosine monophosphate-<sup>13sup>C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
5'-Guanylic acid- 13C10 (5'-GMP- 13C10 dilithium; 5'-guanosine monophosphate- 13C10) dilithium is 13C-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
|
-
- HY-N5134S2
-
5'-GMP-<sup>15sup>N5 dilithium; 5'-guanosine monophosphate-<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
5'-Guanylic acid- 15N5 (5'-GMP- 15N5 dilithium; 5'-guanosine monophosphate- 15N5) dilithium is 15N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
|
-
- HY-W009162S1
-
5'-Cytidylic acid-<sup>13sup>C9 dilithium; 5'-CMP-<sup>13sup>C9 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
Cytidine 5′-monophosphate- 13C9 (5'-Cytidylic acid- 13C9 dilithium; 5'-CMP- 13C9) dilithium is 13C-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
|
-
- HY-W009162S4
-
5'-Cytidylic acid-<sup>15sup>N3 dilithium; 5'-CMP-<sup>15sup>N3 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
Cytidine 5′-monophosphate- 15N3 (5'-Cytidylic acid- 15N3 dilithium; 5'-CMP- 15N3) dilithium is 15N labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
|
-
- HY-W048482S1
-
DMT-2'O-TBDMS-rU phosphoramidite-<sup>13sup>C9,<sup>15sup>N2
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
rU Phosphoramidite- 13C9, 15N2 (DMT-2'O-TBDMS-rU phosphoramidite- 13C9, 15N2) is 13C and 15N-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-101981S3
-
5'-Uridylic acid-<sup>13sup>C9,<sup>15sup>N2 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate- 13C9, 15N2 (5'-?Uridylic acid- 13C9, 15N2) dilithium is 13C and 15N-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-B0158S7
-
Cytosine β-D-riboside-<sup>13sup>C9; Cytosine-1-β-D-ribofuranoside-<sup>13sup>C9
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
Isotope-Labeled Compounds
|
Neurological Disease
|
Cytidine- 13C9 (Cytosine β-D-riboside- 13C9; Cytosine-1-β-D-ribofuranoside- 13C9) is 13C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .
|
-
- HY-N0390S
-
L-Glutamic acid 5-amide-<sup>15sup>N
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine- 15N is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-B0434S
-
-
- HY-19821S
-
-
- HY-B0337S2
-
-
- HY-B0412S3
-
-
- HY-N0229S2
-
L-2-Aminopropionic acid-<sup>15sup>N
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
L-Alanine- 15N is the 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system[1].
|
-
- HY-N7092S2
-
D(-)-Fructose-<sup>13sup>C-1
|
Endogenous Metabolite
|
Others
|
D-Fructose- 13C-1 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
|
-
- HY-N0455AS3
-
(S)-(+)-Arginine-1-<sup>13sup>C hydrochloride
|
NO Synthase
Endogenous Metabolite
|
Others
|
L-Arginine-1- 13C (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-B0467AS
-
-
- HY-B1781S
-
Sulfachlorpyridazine-<sup>13sup>C6
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Sulfachloropyridazine- 13C6 is the 13C6 labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria.
|
-
- HY-N7123S1
-
Sulphacetamide-<sup>13sup>C6
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Sulfacetamide- 13C6 is the 13C6 labeled Sulfacetamide. Sulfacetamide (Sulphacetamide), a bacteriostatic sulphonamide, is a popular antibiotic prescribed for treating ocular infections.
|
-
- HY-N7092S4
-
D(-)-Fructose-3-<sup>13sup>C
|
Endogenous Metabolite
|
Others
|
D-Fructose-3- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
|
-
- HY-N7092S5
-
-
- HY-N7092S6
-
-
- HY-N7092S7
-
D(-)-Fructose-6-<sup>13sup>C
|
Endogenous Metabolite
|
Others
|
D-Fructose-6- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
|
-
- HY-N7092S20
-
-
- HY-N7092S21
-
-
- HY-B1449S2
-
-
- HY-B1449S3
-
-
- HY-B1449S4
-
-
- HY-W010042S1
-
L-(-)-Glucose-<sup>13sup>C-1
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
L-Glucose- 13C-1 is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake[1][2].
|
-
- HY-W010042S2
-
L-(-)-Glucose-<sup>13sup>C-2
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
L-Glucose- 13C-2 is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake[1][2].
|
-
- HY-42680S1
-
D-(-)-Tagatose-<sup>13sup>C-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
D-Tagatose- 13C-1 is the 13C labeled D-Tagatose. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit jui
|
-
- HY-78139S
-
L-(-)-Xylose-1-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Others
|
L-Xylose-1- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
|
-
- HY-78139S1
-
L-(-)-Xylose-2-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Others
|
L-Xylose-2- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
|
-
- HY-78139S2
-
L-(-)-Xylose-5-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Others
|
L-Xylose-5- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
|
-
- HY-N0210S1
-
-
- HY-N0210S2
-
-
- HY-N0210S3
-
-
- HY-N0210S4
-
-
- HY-B0252S2
-
HCTZ-<sup>13sup>C6
|
TGF-beta/Smad
Potassium Channel
|
|
Hydrochlorothiazide- 13C6 is the 13C labeled Hydrochlorothiazide[1]. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[2][3][4].
|
-
- HY-B1449S7
-
-
- HY-B1659S4
-
Glycerin-<sup>13sup>C2
|
Endogenous Metabolite
|
|
Glycerol- 13C2 is the 13C labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].
|
-
- HY-B1659S5
-
Glycerin-<sup>13sup>C3
|
Endogenous Metabolite
|
|
Glycerol- 13C3 is the 13C labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].
|
-
- HY-N0666S10
-
[3-<sup>13sup>C]Aspartic acid
|
Endogenous Metabolite
|
Cardiovascular Disease
|
L-Aspartic acid- 13C-1 is the deuterium labeled L-Aspartic acid[1]. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly[2][3].
|
-
- HY-N2362S5
-
DL-2-Aminopropionic acid-<sup>15sup>N
|
Endogenous Metabolite
|
Metabolic Disease
|
DL-Alanine- 15N is the 15N labeled DL-Alanine[1]. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[2][3][4][5][6][7].
|
-
- HY-Y0781S3
-
Acetylformic acid-<sup>13sup>C-2 sodium
|
Endogenous Metabolite
|
Others
|
Pyruvic acid- 13C-2 (sodium) is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
|
-
- HY-N6779S
-
Terinin-<sup>13sup>C7
|
Isotope-Labeled Compounds
|
Infection
|
Patulin- 13C7 (Terinin- 13C7) is the 13C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage [5].
|
-
- HY-N6746S1
-
NSC 186-<sup>13sup>C13
|
Isotope-Labeled Compounds
|
Cancer
|
Citrinin- 13C13 (NSC 186- 13C13) is the 13C labeled Citrinin (HY-N6746) . Citrinin is a mycotoxin which causes contamination in the food and is associated with different toxic effects. Citrinin is usually found together with another nephrotoxic mycotoxin, Ochratoxin A. Citrinin is also reported to possess a broad spectrum of bioactivities, including antibacterial, antifungal, and potential anticancer and neuro-protective effects in vitro .
|
-
- HY-78131S3
-
(±)-Ibuprofen-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Cancer
|
Ibuprofen- 13C6 ((±)-Ibuprofen- 13C6) is a 13C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers [5].
|
-
- HY-W777457
-
-
- HY-B2176S2
-
Adenosine 5'-triphosphate-<sup>13sup>C dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
ATP- 13C (Adenosine 5'-triphosphate- 13C) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
|
-
- HY-113066S2
-
GDP-d<sup>13sup> dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
Potassium Channel
|
Inflammation/Immunology
|
Guanosine 5'-diphosphate-d13 (GDP-d13) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
|
-
- HY-N0136S1
-
(±)-Dihydroquercetin-<sup>13sup>C3
|
Autophagy
Tyrosinase
|
Inflammation/Immunology
|
(±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3) is a derivative of (±)-Taxifolin, labeled with 13C3. (±)-Taxifolin is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
|
-
- HY-B0111RS
-
Dihydrospirorenone-<sup>13sup>C3
|
Isotope-Labeled Compounds
|
Endocrinology
|
Drospirenone- 13C3 is 13C labeled Drospirenone. Drospirenone (Dihydrospirorenone) is a synthetic progesterone that is an analog of Spironolactone .
|
-
- HY-B0228S10
-
(R)-(-)-3-Hydroxybutanoic acid-<sup>13sup>C2 sodium; (R)-3-Hydroxybutyric acid-<sup>13sup>C2 sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
(R)-3-Hydroxybutanoic acid- 13C2 (sodium) is the 13C labeled (R)-3-Hydroxybutanoic acid (sodium) (HY-W015851). (R)-3-Hydroxybutanoic acid (sodium) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2][3].
|
-
- HY-W015851S2
-
(R)-(-)-3-Hydroxybutanoic acid-<sup>13sup>C4 sodium; (R)-3-Hydroxybutyric acid-<sup>13sup>C4 sodium
|
Isotope-Labeled Compounds
|
Others
|
(R)-3-Hydroxybutanoic acid-13C4 (sodium) is an active compound. (R)-3-Hydroxybutanoic acid-13C4 (sodium) can be used for kinds of research.
|
-
- HY-W393970S3
-
5'-Deoxyguanylic acid-<sup>13sup>C10,<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
|
Others
|
2′-Deoxyguanosine 5′-monophosphate- 13C10, 15N5 (5'-Deoxyguanylic acid- 13C10, 15N5) dilithium is 13C and 15N-labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
|
-
- HY-N0215S9
-
(S)-2-Amino-3-phenylpropionic acid-<sup>13sup>C9,<sup>15sup>N,d8
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
L-Phenylalanine- 13C9, 15N,d8 is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0455AS4
-
(S)-(+)-Arginine-<sup>13sup>C6,<sup>15sup>N4,d7 hydrochloride
|
Isotope-Labeled Compounds
NO Synthase
Endogenous Metabolite
|
Others
|
L-Arginine- 13C6, 15N4,d7 (hydrochloride) is the deuterium, 13C-, and 15-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-W050145S2
-
1,6-Anhydro-β-D-glucopyranose-<sup>13sup>C6; 1,6-Anhydro-β-D-glucose-<sup>13sup>C6
|
Endogenous Metabolite
|
Metabolic Disease
|
Levoglucosan- 13C6 is the 13C labeled Levoglucosan[1]. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature[2].
|
-
- HY-B0289S
-
-
- HY-W015913S
-
Sodium pyruvate-<sup>13sup>C3
|
Reactive Oxygen Species
Endogenous Metabolite
|
Metabolic Disease
|
Sodium 2-oxopropanoate- 13C3 is the 13C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].
|
-
- HY-139145S
-
Trimethylopropane phosphate-<sup>13sup>C3
|
GABA Receptor
|
Neurological Disease
|
Etbicyphat- 13C3 is the 13C labeled Etbicyphat (HY-139145). Etbicyphat is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors[1][2].
|
-
- HY-12857S
-
-
- HY-N0717S6
-
Valine-<sup>13sup>C5
|
Endogenous Metabolite
|
Others
|
L-Valine- 13C5 is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
- HY-113251S1
-
-
- HY-100532S
-
-
- HY-117275S1
-
Meclofenamate-<sup>13sup>C6
|
Isotope-Labeled Compounds
Gap Junction Protein
Endogenous Metabolite
|
Inflammation/Immunology
|
Meclofenamic acid- 13C6 is the 13C6 labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
|
-
- HY-12542S
-
F 368-<sup>13sup>C3
|
Isotope-Labeled Compounds
Glutathione Reductase
|
Neurological Disease
Inflammation/Immunology
|
Dantrolene- 13C3 is the 13C3 labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
|
-
- HY-15037S2
-
GP 45840-<sup>13sup>C6
|
Isotope-Labeled Compounds
COX
Apoptosis
|
Inflammation/Immunology
|
Diclofenac- 13C6 (Sodium) is the 13C6 labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
|
-
- HY-B0497S1
-
BAY2353-<sup>13sup>C6
|
Isotope-Labeled Compounds
STAT
Parasite
Antibiotic
|
Infection
Cancer
|
Niclosamide- 13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
|
-
- HY-B0975S
-
Phenoxymethylpenicillin-<sup>13sup>C6 potassium salt
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Penicillin V- 13C6 (potassium) is the 13C6 labeled Penicillin V (potassium). Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis.
|
-
- HY-15926S
-
2-Nitrophenyl β-D-galactopyranoside-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Others
|
ONPG- 13C is the 13C labeled ONPG. ONPG is a colorimetric and spectrophotometric substrate for detection of β-galactosidase activit[1][2].
|
-
- HY-150679S
-
-
- HY-B0285AS
-
MK-870-<sup>15sup>N3 hydrochloride
|
Apoptosis
TRP Channel
Sodium Channel
|
|
Amiloride- 15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.
|
-
- HY-B0497BS
-
BAY2353-<sup>13sup>C6 monohydrate
|
STAT
Parasite
Antibiotic
|
|
Niclosamide- 13C6 (monohydrate) is the 13C labeled Niclosamide monohydrate[1]. Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[2]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[5]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[3][4][6].
|
-
- HY-B0892S3
-
-
- HY-B1409S
-
ISDN-<sup>13sup>C6
|
NO Synthase
|
Cardiovascular Disease
|
Isosorbide dinitrate- 13C6 is the 13C labeled Isosorbide dinitrate[1]. Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI)[2].
|
-
- HY-B1779S5
-
D-(+)-Saccharose-<sup>13sup>C6
|
Endogenous Metabolite
|
|
Sucrose-13C6 is the 13C labeled Sucrose[1]. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al[2].
|
-
- HY-N1380S2
-
2-Methoxyphenol-<sup>13sup>C6
|
COX
NF-κB
Endogenous Metabolite
|
Inflammation/Immunology
|
Guaiacol- 13C6 is the 13C labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].
|
-
- HY-B0421S2
-
Mycophenolate-<sup>13sup>C17
|
Isotope-Labeled Compounds
Flavivirus
|
Cancer
|
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
|
-
- HY-W013636S3
-
Alpha-Ketoglutaric acid-<sup>13sup>C
|
Isotope-Labeled Compounds
|
Others
|
2-Ketoglutaric acid- 13C (Alpha-Ketoglutaric acid- 13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
|
-
- HY-13407S
-
BL 193-<sup>13sup>C2
|
Bcl-2 Family
|
Others
|
Gossypol-13C2 (BL 193-13C2) is an active compound. Gossypol-13C2 can be used for kinds of research.
|
-
- HY-B1422S
-
Aminacrine-<sup>13sup>C6
|
Bacterial
HIV
Isotope-Labeled Compounds
|
Infection
|
9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
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-
- HY-15407S3
-
AHU-377-<sup>13sup>C4
|
Isotope-Labeled Compounds
Neprilysin
|
Infection
|
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 [5].
|
-
- HY-109120S1
-
A4250-<sup>13sup>C6
|
Apical Sodium-Dependent Bile Acid Transporter
Isotope-Labeled Compounds
|
Metabolic Disease
|
Odevixibat- 13C6 is 13C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .
|
-
- HY-N7093S
-
Strawberry furanone-<sup>13sup>C2
|
Isotope-Labeled Compounds
|
Others
|
Furaneol- 13C2 is 13C labeled Nonanal (HY-N8016). Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity .
|
-
- HY-N0623S6
-
-
- HY-W014423S1
-
H-His-OH-<sup>13sup>C6,<sup>15sup>N3,d5 hydrochloride hydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
L-Histidine- 13C6, 15N3,d5 (hydrochloride hydrate) is the deuterium, 13C-, and 15-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-A0181S4
-
AMP-<sup>13sup>C10,<sup>15sup>N5,d12 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Adenosine monophosphate- 13C10, 15N5,d12 (AMP- 13C10, 15N5,d12) dilithium is 13C and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
|
-
- HY-B0495S
-
LTG-<sup>13sup>C3,d3; BW430C-<sup>13sup>C3,d3
|
Sodium Channel
Autophagy
|
Neurological Disease
|
Lamotrigine- 13C3,d3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
|
-
- HY-N0390S3
-
L-Glutamic acid 5-amide-<sup>13sup>C5,<sup>15sup>N2,d5
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine- 13C5, 15N2,d5 is the deuterium, 13C-, and 15-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-P0265AS
-
Amyloid Beta-Peptide-<sup>15sup>N (1-40) (human) TFA; Amyloid β-Peptide-<sup>15sup>N (1-40) (human) TFA
|
Amyloid-β
|
Neurological Disease
|
β-Amyloid- 15N (1-40) (TFA) is the 15N-labledβ-Amyloid (1-40) (TFA). β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease[1].
|
-
- HY-N0215S2
-
(S)-2-Amino-3-phenylpropionic acid-<sup>13sup>C
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
L-Phenylalanine- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-B0113S3
-
H 16868-<sup>13sup>C,d3
|
Proton Pump
Autophagy
Bacterial
Phospholipase
|
Infection
Metabolic Disease
Cancer
|
Omeprazole- 13C,d3 is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].
|
-
- HY-W007318S
-
-
- HY-N0455AS
-
(S)-(+)-Arginine-<sup>15sup>N2 hydrochloride
|
NO Synthase
Endogenous Metabolite
|
Others
|
L-Arginine- 15N2 (hydrochloride) is the 15N-labeled L-Arginine (hydrochloride). L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-N0229S1
-
L-2-Aminopropionic acid-1-<sup>13sup>C
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
L-Alanine-1- 13C is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-W015824S2
-
-
- HY-N0455AS1
-
(S)-(+)-Arginine-<sup>15sup>N4 hydrochloride
|
Isotope-Labeled Compounds
NO Synthase
Endogenous Metabolite
|
Others
|
L-Arginine- 15N4 (hydrochloride) is the 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis[1].
|
-
- HY-N0215S5
-
(S)-2-Amino-3-phenylpropionic acid-<sup>15sup>N
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
L-Phenylalanine- 15N is the 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-41417S4
-
Caprylic acid-<sup>13sup>C4
|
Endogenous Metabolite
|
Metabolic Disease
|
Octanoic acid- 13C4 is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-N7092S
-
D(-)-Fructose-<sup>13sup>C6
|
Endogenous Metabolite
|
Others
|
D-Fructose- 13C6 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
|
-
- HY-N0229S6
-
-
- HY-N0229S7
-
-
- HY-N0390S4
-
L-Glutamic acid 5-amide-5-<sup>13sup>C
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine-5- 13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-N0390S5
-
L-Glutamic acid 5-amide-1-<sup>13sup>C
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine-1- 13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-N0390S9
-
L-Glutamic acid 5-amide-<sup>15sup>N-1
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine- 15N-1 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-N0455AS6
-
(S)-(+)-Arginine-<sup>13sup>C6 hydrochloride
|
Isotope-Labeled Compounds
NO Synthase
Endogenous Metabolite
|
Others
|
L-Arginine- 13C6 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-N2362S
-
DL-2-Aminopropionic acid-<sup>13sup>C-1
|
Endogenous Metabolite
|
Metabolic Disease
|
DL-Alanine- 13C-1 is the 13C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].
|
-
- HY-N2362S1
-
DL-2-Aminopropionic acid-<sup>13sup>C-3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
DL-Alanine- 13C-3 is the 13C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].
|
-
- HY-B0351S1
-
2-Aminoethanesulfonic acid-<sup>13sup>C2
|
Autophagy
Endogenous Metabolite
|
Metabolic Disease
|
Taurine- 13C2 is the 13C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes[1][2][3].
|
-
- HY-19528S1
-
SAH (S-Adenosylhomocysteine)-<sup>13sup>C5
|
Endogenous Metabolite
|
Metabolic Disease
|
SAH- 13C5 is the 13C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].
|
-
- HY-N0390S11
-
L-Glutamic acid 5-amide-2-<sup>13sup>C
|
Isotope-Labeled Compounds
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine-2- 13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-78131S1
-
-
- HY-B0252S1
-
HCTZ-<sup>13sup>C,d2
|
Isotope-Labeled Compounds
TGF-beta/Smad
Potassium Channel
|
Cardiovascular Disease
Metabolic Disease
|
Hydrochlorothiazid- 13C,d2 is the 13C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].
|
-
- HY-B0330S2
-
-
- HY-B0335S1
-
GEA 6414-<sup>13sup>C6
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
Tolfenamic acid- 13C6 is the 13C6 labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
|
-
- HY-W069721S1
-
-
- HY-N7032S
-
-
- HY-N0210S16
-
D-(+)-Galactose-<sup>13sup>C6
|
Endogenous Metabolite
|
Neurological Disease
|
D-Galactose- 13C6 is the deuterium labeled D-Galactose (HY-N0210). D-Galactose is a natural aldohexose and C-4 epimer of glucose[1][2].
|
-
- HY-14781S2
-
5-MTHF-<sup>13sup>C5
|
DNA/RNA Synthesis
Endogenous Metabolite
Reactive Oxygen Species
|
|
Levomefolic acid- 13C5 is the 13C labeled Levomefolic acid[1]. Levomefolic acid (5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements[2][3].
|
-
- HY-B1449S
-
-
- HY-B1449S10
-
β-Uridine-<sup>13sup>C5
|
Isotope-Labeled Compounds
|
Cancer
|
Uridine- 13C5 (β-Uridine- 13C5) is a 13C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.
|
-
- HY-W007376S
-
3-Formylindole-<sup>13sup>C3
|
Isotope-Labeled Compounds
|
Others
|
Indole-3-carboxaldehyde- 13C (3-Formylindole- 13C) is a 13C labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin .
|
-
- HY-W778203
-
Hydroxyethanoic acid-<sup>13sup>C2
|
Isotope-Labeled Compounds
|
Others
|
Glycolic acid- 13C2 is the 13C-labeled Glycolic acid (HY-W015967). Glycolic acid- 13C2 is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
|
-
- HY-N7092S22
-
D(-)-Fructose-<sup>13sup>C3
|
Isotope-Labeled Compounds
|
Others
|
D-Fructose- 13C3 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-N7092S24
-
D(-)-Fructose-<sup>13sup>C4
|
Isotope-Labeled Compounds
|
Others
|
D-Fructose- 13C4 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-W048482S4
-
DMT-2'O-TBDMS-rU phosphoramidite-<sup>15sup>N
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
rU Phosphoramidite- 15N (DMT-2'O-TBDMS-rU phosphoramidite- 15N) is 15N labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-W753983
-
Acetylformic acid-<sup>13sup>C3
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Pyruvic acid-13C is isotype-labeled compound of Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .
|
-
- HY-W010042S3
-
-
- HY-B1449S11
-
-
- HY-N0803S1
-
β-Myrcene-<sup>13sup>C3
|
NF-κB
Isotope-Labeled Compounds
|
Others
|
Myrcene- 13C3 is 13C labeled trans-2-Decenal (HY-W015551). trans-2-Decenal is an important raw material and intermediate used in organic synthesis, medicine, pesticides and dyes.
|
-
- HY-W020678S
-
-
- HY-144730
-
|
HIV
|
Inflammation/Immunology
|
gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 µM and CC50 of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells .
|
-
- HY-W334800S
-
L-threo-2,6-Diaminopimelic acid-<sup>13sup>C7,<sup>15sup>N2
|
Isotope-Labeled Compounds
|
Others
|
(2S,6S)-2,6-Diaminoheptanedioic acid- 13C7, 15N2 (L-threo-2,6-Diaminopimelic acid- 13C7, 15N2) is 13C and 15N-labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).
|
-
- HY-10065S
-
AG-013736-<sup>13sup>C,d3
|
VEGFR
PDGFR
|
Cancer
|
Axitinib- 13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.
|
-
- HY-17427S
-
BW1592-<sup>15sup>N,d2
|
HIV
Reverse Transcriptase
Endogenous Metabolite
|
Infection
|
Emtricitabine- 15N,d2 is a 15N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.
|
-
- HY-W014632S
-
Desacetyl triflusal-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Others
|
4-Trifluoromethylsalicylic acid- 13C6 is the 13C labeled 4-Trifluoromethylsalicylic acid[1]. 4-Trifluoromethylsalicylic acid is a platelet aggregation inhibitor[2].
|
-
- HY-A0023AS
-
-
- HY-15407AS
-
AHU-377-<sup>13sup>C4 hemicalcium salt
|
Isotope-Labeled Compounds
Neprilysin
|
Cardiovascular Disease
|
Sacubitril- 13C4 (hemicalcium salt) is a 13C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696[1].
|
-
- HY-15605S
-
LGX818-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Raf
|
Cancer
|
Encorafenib- 13C,d3 is the 13C- and deuterium labeled Encorafenib. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).
|
-
- HY-10805S
-
-
- HY-17506S1
-
-
- HY-W014423S2
-
H-His-OH-<sup>13sup>C6 hydrochloride hydrate
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Histidine- 13C6 (hydrochloride hydrate) is the 13C-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-W014423S5
-
-
- HY-10284S1
-
BI 1356-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Dipeptidyl Peptidase
Autophagy
Ferroptosis
|
Metabolic Disease
|
Linagliptin- 13C,d3 is the 13C- and deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. Linagliptin-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-10582S2
-
dl-Flurbiprofen-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
Flurbiprofen- 13C,d3 is the 13C- and deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].
|
-
- HY-113365S2
-
4-Cholesten-3-one-<sup>13sup>C2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
|
Cholestenone- 13C2 is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2][3].
|
-
- HY-13955S2
-
-
- HY-14369S
-
-
- HY-16060S2
-
ARN-509-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Androgen Receptor
|
Cancer
|
Apalutamide- 13C,d3 is the 13C- and deuterium labeled Apalutamide. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].
|
-
- HY-17396S
-
KP363-<sup>13sup>C,d3 hydrochloride
|
Isotope-Labeled Compounds
Fungal
Antibiotic
|
Infection
|
Butenafine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
|
-
- HY-17492S1
-
-
- HY-17492S2
-
-
- HY-18252S
-
-
- HY-50904S1
-
BIBF 1120-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
PDGFR
VEGFR
FGFR
|
Cancer
|
Nintedanib- 13C,d3 is the 13C- and deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
|
-
- HY-A0166S
-
MK0791-<sup>15sup>N,d3
|
Bacterial
Antibiotic
|
Infection
|
Cilastatin- 15N,d3 is a 15N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct[1][2][3].
|
-
- HY-B0165AS
-
-
- HY-B0192S1
-
-
- HY-B0227S2
-
RP-19583-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
COX
Apoptosis
|
Inflammation/Immunology
|
Ketoprofen- 13C,d3 is the 13C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].
|
-
- HY-B0621S1
-
-
- HY-B0740S1
-
-
- HY-W009300S1
-
-
- HY-B0263S1
-
-
- HY-W014225S
-
-
- HY-B0167S1
-
-
- HY-10888S
-
KW-6002-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Adenosine Receptor
|
Neurological Disease
|
Istradefylline- 13C,d3 is the 13C- and deuterium labeled Istradefylline. Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
|
-
- HY-I0301S
-
-
- HY-112174S
-
UDP-α-D-N-Acetylglucosamine-<sup>13sup>C disodium
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
UDP-GlcNAc- 13C (disodium) is the 13C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O[1][2].
|
-
- HY-W010382S
-
2-Oxosuccinic acid-<sup>13sup>C4
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Metabolic Disease
|
Oxaloacetic acid- 13C4 is the 13C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis[1][2][3].
|
-
- HY-111772S
-
-
- HY-10208S1
-
GW786034-<sup>13sup>C,d3
|
VEGFR
PDGFR
Autophagy
FGFR
c-Kit
|
Cancer
|
Pazopanib- 13C,d3 is the deuterium and 13C labeled Pazopanib[1]. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].
|
-
- HY-12009S
-
GW786034-<sup>13sup>C,d3 hydrochloride
|
VEGFR
PDGFR
Autophagy
c-Fms
FGFR
c-Kit
|
Cancer
|
Pazopanib- 13C,d3 (hydrochloride) is the deuterium and 13C labeled Pazopanib hydrochloride[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].
|
-
- HY-W035903S
-
Monoethanolamine-<sup>13sup>C2 Hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
2-Aminoethan-1-ol- 13C2 hydrochloride is the 13C labeled 2-Aminoethan-1-ol hydrochloride[1].
|
-
- HY-W392933S
-
-
- HY-14779S
-
BAY 632521-<sup>13sup>C,d6
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
Riociguat- 13C,d6 is the 13C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
|
-
- HY-B0596S
-
TA-0910-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
|
Neurological Disease
|
Taltirelin- 13C,d3 (TA-0910- 13C,d3) is 13C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca 2+ concentration (Ca 2+ release).
|
-
- HY-N0349S1
-
Methyl 4-hydroxybenzoate-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Infection
|
Methyl Paraben- 13C6 (Methyl 4-hydroxybenzoate- 13C6) is a 13C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .
|
-
- HY-W727879
-
ABT-494-<sup>15sup>N,d2
|
Isotope-Labeled Compounds
|
Others
|
Upadacitinib- 15N,d2 (ABT-494- 15N,d2) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib- 15N,d2 (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib- 15N,d2 (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib- 15N,d2 (ABT-494) can be used for several autoimmune disorders research .
|
-
- HY-A0181S3
-
AMP-<sup>13sup>C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Adenosine monophosphate- 13C10 (AMP- 13C10) dilithium is 13C-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
|
-
- HY-113225S5
-
-
- HY-113225S3
-
-
- HY-W768340
-
D-(+)-Saccharose-<sup>13sup>C6-1
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
Sucrose- 13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .
|
-
- HY-106827S1
-
RU 27987-<sup>13sup>C,d3
|
Androgen Receptor
Phosphatase
Progesterone Receptor
Isotope-Labeled Compounds
|
Endocrinology
|
Trimegestone- 13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes .
|
-
- HY-14655S1
-
-
- HY-B0103AS2
-
-
- HY-B0374AS
-
BDF5895-<sup>13sup>C,d3 hydrochloride
|
Imidazoline Receptor
Isotope-Labeled Compounds
|
Neurological Disease
|
Moxonidine- 13C,d3 hydrochloride is 13C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) hydrochloride is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.
|
-
- HY-B0250S
-
BCH-189-<sup>15sup>N,d2
|
HBV
HIV
Reverse Transcriptase
Isotope-Labeled Compounds
|
Infection
Cancer
|
Lamivudine- 15N,d2 is 15N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
- HY-126857AS1
-
-
- HY-W102356S1
-
-
- HY-10981S2
-
E7080-<sup>15sup>N,d4
|
VEGFR
c-Kit
FGFR
RET
PDGFR
Isotope-Labeled Compounds
|
Cancer
|
Lenvatinib- 15N,d4 is 15N and deuterated labeled Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities .
|
-
- HY-10353AS1
-
-
- HY-N0390S1
-
L-Glutamic acid 5-amide-<sup>13sup>C5
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine- 13C5 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-50667S
-
BMS-562247-01-<sup>13sup>C,d3
|
Factor Xa
|
Cardiovascular Disease
|
Apixaban- 13C,d3 is a deuterium and 13C labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1].
|
-
- HY-32351AS1
-
-
- HY-W015824S3
-
-
- HY-B0859S
-
4-Chloro-2-Methylphenoxyacetic acid-<sup>13sup>C8
|
Isotope-Labeled Compounds
|
Others
|
MCPA- 13C8 is the 13C-labeled MCPA. MCPA is a phenoxy herbicide, and widely used to control annual and perennial broad leaved weeds, including poppy, thistles and docks, in crops such as cereals, rice, linseed, flax, grassland and turf[1][2].
|
-
- HY-129242S
-
-
- HY-10002S
-
-
- HY-W012722BS1
-
α-Ketoisocaproic acid-<sup>13sup>C (sodium)
|
Isotope-Labeled Compounds
|
Others
|
4-Methyl-2-oxopentanoic acid- 13C (sodium) is the 13C labeled 4-Methyl-2-oxopentanoic acid sodium[1].
|
-
- HY-113046S
-
5-Methyl THF-<sup>13sup>C5
|
Endogenous Metabolite
|
Metabolic Disease
|
5-Methyltetrahydrofolic acid- 13C5 is the 13C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid[1].
|
-
- HY-N0215S7
-
(S)-2-Amino-3-phenylpropionic acid-3-<sup>13sup>C
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
L-Phenylalanine-3- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0229S8
-
L-2-Aminopropionic acid-<sup>13sup>C3
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
L-Alanine- 13C3 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-N0229S9
-
L-2-Aminopropionic acid-<sup>13sup>C2
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
L-Alanine- 13C2 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-N0390S8
-
L-Glutamic acid 5-amide-<sup>15sup>N2
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine- 15N2 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-10331S1
-
BAY 73-4506-<sup>13sup>C,d3
|
VEGFR
Autophagy
PDGFR
Raf
RET
|
Cancer
|
Regorafenib- 13C,d3 is the 13C- and deuterium labeled Regorafenib. Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively.
|
-
- HY-136450S1
-
TCBZ-SO-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
Parasite
BCRP
|
Infection
|
Triclabendazole sulfoxide- 13C,d3 is the 13C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].
|
-
- HY-Y0479AS
-
-
- HY-17453S1
-
GR 33343X-<sup>13sup>C6 xinafoate
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Inflammation/Immunology
Endocrinology
|
Salmeterol- 13C6 (xinafoate) is the 13C6 labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.
|
-
- HY-N0210S12
-
-
- HY-N0172S
-
3,4-Dihydroxycinnamic acid-<sup>13sup>C3
|
Bacterial
Fungal
|
Infection
|
Caffeic acid- 13C3 is an 13C labeled caffeic acid. Caffeic acid is a phytonutrient belonging to the flavonoids. Caffeic acid and its derivatives, are potential antimicrobial agents, chronic infection induced by microbes such as bacteria, fungi, and viruses[1].
|
-
- HY-100561S
-
4-Hydroxy-TEMPO-d17,<sup>15sup>N
|
Autophagy
Reactive Oxygen Species
|
Cancer
|
Tempol-d17, 15N is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS)[2][3].
|
-
- HY-101981S
-
5'-?Uridylic acid-<sup>15sup>N2
|
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate-15N2 is the 15N labeled Uridine 5'-monophosphate[1]. Uridine 5'-monophosphate (5'- Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk[2].
|
-
- HY-10250S
-
-
- HY-150660S
-
25-Hydroxy Vitamin D2-<sup>13sup>C5
|
Isotope-Labeled Compounds
|
Others
|
25-Hydroxyvitamin D2-(20,21,22,26,27- 13C5) solution is the 13C labeled 25-Hydroxyvitamin D2[1].
|
-
- HY-150663S
-
1,25-Dihydroxyvitamin D3-<sup>13sup>C5
|
Isotope-Labeled Compounds
|
Others
|
1α,25-Dihydroxyvitamin D3-(23,24,25,26,27- 13C5) solution is the 13C labeled 1α,25-Dihydroxyvitamin D3[1].
|
-
- HY-B1075AS
-
MK-0955 (benzylamine)-<sup>13sup>C3
|
Bacterial
Antibiotic
|
Infection
|
(Rac)-Fosfomycin (benzylamine)- 13C3 is the 13C labeled Fosfomycin[1]. Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[2][3].
|
-
- HY-Y0262BS
-
-
- HY-N6792S
-
T-2 Mycotoxin-<sup>13sup>C24
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
T-2 Toxin- 13C24 (T-2 Mycotoxin- 13C24) is 13C-labeled T-2 Toxin (HY-N6792). T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues .
|
-
- HY-126373S1
-
SN-38G-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Others
|
SN-38 glucuronide- 13C6 is the 13C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
|
-
- HY-14781S1
-
5-MTHF-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
|
Others
|
Levomefolic acid- 13C,d3is the deuterium labeledLevomefolic acid(HY-14781) . Levomefolic acid (5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements .
|
-
- HY-W017401S
-
1,2-Benzothiazol-3-one-<sup>13sup>C5
|
Isotope-Labeled Compounds
Bacterial
|
Others
|
Benzisothiazolinone-13C5 (1,2-Benzothiazol-3-one-13C5) is a 13C-labeled Benzisothiazolinone. Benzisothiazolinone is widely used as an antiseptic and antibacterial agent .
|
-
- HY-66011AS4
-
BAY 12-8039-<sup>13sup>C,d3
|
Isotope-Labeled Compounds
|
Cancer
|
Moxifloxacin- 13C,d3 hydrochloride (BAY 12-8039- 13C,d3) is 13C and deuterated labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.
|
-
- HY-B1654S
-
FAD-<sup>13sup>C5 ammonium
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
Flavin adenine dinucleotide- 13C5 (FAD- 13C5) ammonium is 13C labeled Flavin adenine dinucleotide (HY-B1654). Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
|
-
- HY-W016814S
-
cis-Aconitic acid-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Others
|
(Z)-Aconitic acid- 13C6 is the 13C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
|
-
- HY-N7092S23
-
D(-)-Fructose-<sup>13sup>C3-1
|
Isotope-Labeled Compounds
|
Others
|
D-Fructose- 13C3-1 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-B2176S6
-
Adenosine 5'-triphosphate-<sup>13sup>C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
ATP- 13C10 (Adenosine 5'-triphosphate- 13C10) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
|
-
- HY-B2176S5
-
Adenosine 5'-triphosphate-<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
ATP- 15N5 (Adenosine 5'-triphosphate- 15N5) dilithium is 15N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
|
-
- HY-138615S2
-
-
- HY-138615S1
-
-
- HY-B2236S1
-
(±)-2,6-Diaminocaproic acid-<sup>13sup>C6 hydrochloride
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
DL-Lysine- 13C6 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6 hydrochloride) is 13C-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-B2236S3
-
(±)-2,6-Diaminocaproic acid-<sup>15sup>N2 hydrochloride
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
DL-Lysine- 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 15N2 hydrochloride) is 15N labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-113066S1
-
GDP-<sup>13sup>C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
Potassium Channel
|
Inflammation/Immunology
|
Guanosine 5'-diphosphate- 13C10 (GDP- 13C10) dilithium is 13C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
|
-
- HY-113066S
-
GDP-<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
Potassium Channel
|
Inflammation/Immunology
|
Guanosine 5'-diphosphate- 15N5 (GDP- 15N5) dilithium is 15N labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
|
-
- HY-N0294S1
-
3,4-Dihydroxybenzoic acid-<sup>13sup>C7
|
Isotope-Labeled Compounds
|
Neurological Disease
|
Protocatechuic acid- 13C7 is 13C labeled Protocatechuic acid. Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect.
|
-
- HY-W010392S1
-
-
- HY-125818S5
-
Cytidine triphosphate-<sup>15sup>N3,d14 dilithium; 5'-CTP-<sup>15sup>N3,d14 dilithium
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Infection
Cancer
|
Cytidine-5'-triphosphate- 15N3,d14 (Cytidine triphosphate- 15N3,d14 dilithium; 5'-CTP- 15N3,d14) dilithium is deuterium and 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
|
-
- HY-101400S1
-
dCTP-<sup>15sup>N3,d14 dilithium; 2′-Deoxycytidine-5′-triphosphate-<sup>15sup>N3,d14 dilithium
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
Endogenous Metabolite
|
Metabolic Disease
|
Deoxycytidine triphosphate- 15N3,d14 (dCTP- 15N3,d14 dilithium; 2′-Deoxycytidine-5′-triphosphate- 15N3,d14) dilithium is deuterium and 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
|
-
- HY-N5134S4
-
5'-GMP-<sup>15sup>N5,d12 dilithium; 5'-guanosine monophosphate-<sup>15sup>N5,d12 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
5'-Guanylic acid- 15N5,d12 (5'-GMP- 15N5,d12 dilithium; 5'-guanosine monophosphate- 15N5,d12) dilithium is deuterium and 15N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
|
-
- HY-W009162S3
-
5'-Cytidylic acid-<sup>15sup>N3,d12 dilithium; 5'-CMP-<sup>15sup>N3,d12 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
Cytidine 5′-monophosphate- 15N3,d12 (5'-Cytidylic acid- 15N3,d12 dilithium; 5'-CMP- 15N3,d12) dilithium is deuterium and 15N labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
|
-
- HY-18572S
-
2,4-Dichlorophenoxyacetic acid-<sup>13sup>C6
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
2,4-D- 13C6 is the 13C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[1].
|
-
- HY-N0437S1
-
-
- HY-W097453S
-
-
- HY-N0067S3
-
4-Aminobutyric acid-<sup>13sup>C4
|
Isotope-Labeled Compounds
GABA Receptor
Endogenous Metabolite
|
Neurological Disease
|
γ-Aminobutyric acid- 13C4 is the 13C-labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
|
-
- HY-N0437S3
-
-
- HY-B0033S
-
γ-Vinyl-GABA-<sup>13sup>C,d2 hydrochloride
|
Isotope-Labeled Compounds
GABA Receptor
|
Neurological Disease
|
Vigabatrin- 13C,d2 (hydrochloride) is the 13C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].
|
-
- HY-B0640S
-
WAL801-<sup>13sup>C,d3 hydrobromide
|
Isotope-Labeled Compounds
Histamine Receptor
|
Inflammation/Immunology
Endocrinology
|
Epinastine- 13C,d3 (hydrobromide) is the 13C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action[1][2][3][4].
|
-
- HY-W014223S
-
Ultraviolet absorber UV-0-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Others
|
2,4-Dihydroxybenzophenone- 13C6 (Ultraviolet absorber UV-0- 13C6) is the 13C- and deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone[1].
|
-
- HY-W010452S1
-
-
- HY-W010452S2
-
-
- HY-139427S
-
-
- HY-B0152S1
-
Adenine-8-C13; 9H-Purin-6-amine-8-<sup>13sup>C
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
Adenine- 13C is the 13C labeled Adenine[1]. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[2][3][4].
|
-
- HY-W013059S1
-
DA-CE phosphoramidite-<sup>15sup>N5
|
DNA/RNA Synthesis
|
Others
|
DMT-dA(bz) Phosphoramidite- 15N5 is the 15N labeled DMT-dA(bz) Phosphoramidite[1]. DMT-dA(bz) Phosphoramidite is typically used in the synthesis of DNA[2].
|
-
- HY-A0023AS2
-
-
- HY-136648S5
-
dATP-<sup>13sup>C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
DNA/RNA Synthesis
|
Others
|
2'-Deoxyadenosine-5'-triphosphate- 13C10 (dATP- 13C10) dilithium is 13C-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
|
-
- HY-136648S4
-
dATP-<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
DNA/RNA Synthesis
|
Others
|
2'-Deoxyadenosine-5'-triphosphate- 15N5 (dATP- 15N5) dilithium is 15N labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
|
-
- HY-138616S3
-
2'-Deoxyguanosine-5'-triphosphate-<sup>13sup>C10 dilithium
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
|
Infection
Cancer
|
dGTP- 13C10 (2'-Deoxyguanosine-5'-triphosphate- 13C10) dilithium is 13C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
|
-
- HY-W392933S3
-
Thymidine-5'-phosphate-<sup>13sup>C10 dilithium
|
Isotope-Labeled Compounds
|
Others
|
Thymidine 5'-monophosphate- 13C10 (Thymidine-5'-phosphate- 13C10) dilithium is 13C-labeled Thymidine 5'-monophosphate (HY-W392933).
|
-
- HY-W392933S2
-
Thymidine-5'-phosphate-<sup>15sup>N2 dilithium
|
Isotope-Labeled Compounds
|
Others
|
Thymidine 5'-monophosphate- 15N2 (Thymidine-5'-phosphate- 15N2) dilithium is 15N labeled Thymidine 5'-monophosphate (HY-W392933).
|
-
- HY-W343292S
-
Methyl-2-butyl-acetate fcc-<sup>13sup>C2
|
Isotope-Labeled Compounds
|
|
2-Methylbutyl acetate- 13C2 is 13C labeled 3-Mercaptopentan-2-one.
|
-
- HY-B0203BS2
-
(Rac)-R 065824-d2,<sup>15sup>N
|
NADPH Oxidase
Adrenergic Receptor
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
(Rac)-Nebivolol-d2, 15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
|
-
- HY-W010696AS
-
-
- HY-B1659S
-
-
- HY-N0215S10
-
(S)-2-Amino-3-phenylpropionic acid-<sup>13sup>C9
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
L-Phenylalanine- 13C9 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0215S8
-
(S)-2-Amino-3-phenylpropionic acid-<sup>13sup>C6
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
L-Phenylalanine- 13C6 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0229S14
-
-
- HY-N0229S4
-
L-2-Aminopropionic acid-<sup>13sup>C,d1
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
L-Alanine- 13C,d is the 13C- and deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-N0455AS5
-
(S)-(+)-Arginine-1,2-<sup>13sup>C2 hydrochloride
|
Isotope-Labeled Compounds
NO Synthase
Endogenous Metabolite
|
Others
|
L-Arginine-1,2- 13C2 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-A0132S4
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>18sup>O
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 18O is the 18O labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-A0132S1
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>13sup>C
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 13C is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-A0132S7
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>15sup>N
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 15N is the 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-B2225AS
-
-
- HY-N7032S1
-
UDP-D-Glucose-<sup>13sup>C6 disodium
|
P2Y Receptor
Endogenous Metabolite
|
Neurological Disease
|
Uridine 5′-diphosphoglucose- 13C6 (disodium) is the 13C labeled Uridine 5′-diphosphoglucose disodium salt[1]. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR[2].
|
-
- HY-W015851S
-
[2-13C]Sodium acetate; Sodium [2-13C]acetate; Sodium acetate-2-<sup>13sup>C
|
Endogenous Metabolite
|
Metabolic Disease
|
(R)-3-Hydroxybutanoic acid- 13C (sodium) is the 13C labeled (R)-3-Hydroxybutanoic acid sodium[1]. (R)-3-Hydroxybutanoic acid sodium ((R)-3-Hydroxybutyric acid) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[2][3].
|
-
- HY-W048482S2
-
DMT-2'O-TBDMS-rU phosphoramidite-<sup>13sup>C9
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
rU Phosphoramidite- 13C9 (DMT-2'O-TBDMS-rU phosphoramidite- 13C9) is 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-W048482S3
-
DMT-2'O-TBDMS-rU phosphoramidite-<sup>15sup>N2
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
rU Phosphoramidite- 15N2 (DMT-2'O-TBDMS-rU phosphoramidite- 15N2) is 15N labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-101981S4
-
5'-Uridylic acid-<sup>13sup>C9 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate- 13C9 (5'-?Uridylic acid- 13C9) dilithium is 13C-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-101981S5
-
5'-Uridylic acid-<sup>15sup>N2 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate- 15N2 (5'-?Uridylic acid- 15N2) dilithium is 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-23506S
-
-
- HY-50719S1
-
-
- HY-W127515S
-
-
- HY-Y0989S2
-
1-Phenylethan-1-One-1,2-<sup>13sup>C2
|
Isotope-Labeled Compounds
|
Others
|
Acetophenone-1,2- 13C2 is the 13C-labeled Acetophenone. Acetophenone is an organic compound with simple structure[1].
|
-
- HY-100441S1
-
-
- HY-129974S
-
3,3'-T2-<sup>13sup>C6
|
COX
Endogenous Metabolite
|
Metabolic Disease
|
3,3'-Diiodo-L-thyronine- 13C6 is the 13C labeled 3,3'-Diiodo-L-thyronine[1]. 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[2][3].
|
-
- HY-W393970S2
-
5'-Deoxyguanylic acid-<sup>13sup>C10 dilithium
|
Isotope-Labeled Compounds
|
Others
|
2′-Deoxyguanosine 5′-monophosphate- 13C10 (5'-Deoxyguanylic acid- 13C10) dilithium is 13C-labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
|
-
- HY-W393970S4
-
5'-Deoxyguanylic acid-<sup>15sup>N5 dilithium
|
Isotope-Labeled Compounds
|
Others
|
2′-Deoxyguanosine 5′-monophosphate- 15N5 (5'-Deoxyguanylic acid- 15N5) dilithium is 15N labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
|
-
- HY-W001942S2
-
-
- HY-W012578S1
-
2-methoxy-3-(methylethyl)pyrazine-<sup>13sup>C3
|
Isotope-Labeled Compounds
|
|
2-Isopropyl-3-methoxypyrazine- 13C3 is 13C labeled Octan-2-one.
|
-
- HY-W011090S
-
CMP-<sup>13sup>C9,<sup>15sup>N3
|
Isotope-Labeled Compounds
|
Others
|
((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate- 13C9, 15N3 (sodium) is the 13C and 15N labeled Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate[1].
|
-
- HY-B1640S
-
-
- HY-N0215S14
-
(S)-2-Amino-3-phenylpropionic acid-<sup>15sup>N,d8
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
L-Phenylalanine- 15N,d8 is the deuterium and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0455AS9
-
(S)-(+)-Arginine-<sup>15sup>N4,d7 hydrochloride
|
Isotope-Labeled Compounds
NO Synthase
Endogenous Metabolite
|
Others
|
L-Arginine- 15N4,d7 (hydrochloride) is the deuterium and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-N0390S10
-
L-Glutamic acid 5-amide-1,2-<sup>13sup>C2
|
Isotope-Labeled Compounds
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine-1,2- 13C2 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-32350S
-
-
- HY-N7092S13
-
-
- HY-A0132S2
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>13sup>C-1
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 13C-1 is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-A0132S3
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>13sup>C-2
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 13C-2 is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-A0132S5
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>13sup>C-3
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 13C-3 is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-150661S
-
3-epi-25-Hydroxy Vitamin D3-<sup>13sup>C5
|
Isotope-Labeled Compounds
|
Others
|
3-Epi-25-hydroxyvitamin D3- 13C5 is the 13C labeled 3-Epi-25-hydroxyvitamin D3[1].
|
-
- HY-Y0836S
-
1,4-Diethyl butanedioate-1,2,3,4-<sup>13sup>C4
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Diethyl succinate- 13C4 is the 13C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
|
-
- HY-B0166S8
-
L-Ascorbate-1; Vitamin C-<sup>13sup>C6-1
|
Isotope-Labeled Compounds
|
Cancer
|
L-Ascorbic acid- 13C6-1 (L-Ascorbate-1; Vitamin C- 13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells [5].
|
-
- HY-100043S
-
2-Ethyl-3,5-dimethylpyrazine-<sup>13sup>C2
|
Isotope-Labeled Compounds
|
Others
|
2-Ethyl-3,5-dimethylpyrazine- 13C2 is 13C labeled Nordiphenhydramine (HY-W585858).
|
-
- HY-B0892S
-
-
- HY-P1363S
-
Amyloid β-peptide-<sup>15sup>N (1-42) (human) TFA
|
Amyloid-β
|
Neurological Disease
|
β-Amyloid- 15N (1-42), human (TFA) is the 15N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease[1].
|
-
- HY-A0181S5
-
AMP-<sup>15sup>N5,d12 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Adenosine monophosphate- 15N5,d12 (AMP- 15N5,d12) dilithium is deuterium and 15N labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
|
-
- HY-113225S4
-
-
- HY-W015604S
-
Pyrazine, 2,3-diethyl-5-methyl-<sup>13sup>C2
|
Isotope-Labeled Compounds
|
|
2,3-Diethyl-5-methylpyrazine- 13C2 is 13C labeled 4-Hydroxy-5-methylfuran-3(2H)-one.
|
-
- HY-N0390S7
-
L-Glutamic acid 5-amide-<sup>15sup>N2,d5
|
Isotope-Labeled Compounds
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
L-Glutamine- 15N2,d5 is the deuterium and 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-A0132S12
-
N-Acetyl-2-amino-2-deoxy-D-glucose-<sup>13sup>C6
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
N-Acetyl-D-glucosamine- 13C6 (N-Acetyl-2-amino-2-deoxy-D-glucose- 13C6) is the 13C labled N-Acetyl-D-glucosamine (HY-A0132) . N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of glucose.
|
-
- HY-B2176S3
-
Adenosine 5'-triphosphate-<sup>15sup>N5,d14 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
ATP- 15N5,d14 (Adenosine 5'-triphosphate- 15N5,d14) dilithium is deuterium and 15N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
|
-
- HY-138615S3
-
-
- HY-B0712S1
-
Ro 13-9904-<sup>13sup>C2,d3 triethylammonium salt
|
Antibiotic
Aurora Kinase
GSK-3
Bacterial
Isotope-Labeled Compounds
|
Infection
Inflammation/Immunology
Cancer
|
Ceftriaxone- 13C2,d3 triethylammonium salt is 13C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis [5] .
|
-
- HY-B0094S3
-
Qinghaosu-<sup>13sup>C,d4; NSC 369397-13C,d4
|
Ferroptosis
Akt
Parasite
HCV
Isotope-Labeled Compounds
|
Infection
Neurological Disease
Cancer
|
Artemisinin- 13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
|
-
- HY-103216A
-
|
Adrenergic Receptor
|
Neurological Disease
|
RWJ-52353 hydrochloride is an orally potent, highly selective α2D adrenergic receptor agonist (Ki: 1.5 nM) with potential analgesic effects. RWJ-52353 hydrochloride demonstrated analgesic activity in abdominal tests in rats and mice, and improved agitation in mice in the hot plate test and tail flick test. RWJ-52353 hydrochloride also regulates the organic cation transporter (OCT) subtype, inhibiting rOCT1 and rOCT2 with IC50s of 100 μM and 20 μM respectively; it also activates rOCT3, affecting [3H]-1- in cells. Methyl-4-phenylpyridinium ([3H]MPP) transport .
|
-
- HY-B1278AS
-
Vitamin E acetate-<sup>13sup>C4,d6
|
Endogenous Metabolite
|
Inflammation/Immunology
|
DL-α-Tocopherol acetate- 13C4,d6 is the deuterium and 13C labeled DL-α-Tocopherol acetate[1]. DL-α-Tocopherol acetate is a vitamin E derivative which is often included in the formulations of enteral nutrition[2][3].
|
-
- HY-136648S2
-
dATP-<sup>15sup>N5,d14 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
DNA/RNA Synthesis
|
Others
|
2'-Deoxyadenosine-5'-triphosphate- 15N5,d14 (dATP- 15N5,d14) dilithium is deuterium and 15N labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
|
-
- HY-138616S2
-
2'-Deoxyguanosine-5'-triphosphate-<sup>15sup>N5,d14 dilithium
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
|
Infection
Cancer
|
dGTP- 15N5,d14 (2'-Deoxyguanosine-5'-triphosphate- 15N5,d14) dilithium is deuterium and 15N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
|
-
- HY-W392933S1
-
Thymidine-5'-phosphate-<sup>15sup>N2,d13 dilithium
|
Isotope-Labeled Compounds
|
Others
|
Thymidine 5'-monophosphate- 15N2,d13 (Thymidine-5'-phosphate- 15N2,d13) dilithium is deuterium and 15N labeled Thymidine 5'-monophosphate (HY-W392933).
|
-
- HY-B0151S1
-
3β-Hydroxy-5-pregnen-20-one-<sup>13sup>C2,d2
|
Isotope-Labeled Compounds
Autophagy
Cannabinoid Receptor
Endogenous Metabolite
TRP Channel
|
Neurological Disease
|
Pregnenolone- 13C2,d2 is the deuterium and 13C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[1][2][3][4].
|
-
- HY-W334800S2
-
L-threo-2,6-Diaminopimelic acid-<sup>13sup>C7
|
Isotope-Labeled Compounds
|
Others
|
(2S,6S)-2,6-Diaminoheptanedioic acid- 13C7 (L-threo-2,6-Diaminopimelic acid- 13C7) is 13C-labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).
|
-
- HY-W334800S1
-
L-threo-2,6-Diaminopimelic acid-<sup>15sup>N2
|
Isotope-Labeled Compounds
|
Others
|
(2S,6S)-2,6-Diaminoheptanedioic acid- 15N2 (L-threo-2,6-Diaminopimelic acid- 15N2) is 15N labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).
|
-
- HY-W048482S
-
DMT-2'O-TBDMS-rU phosphoramidite-<sup>13sup>C2,d1
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
rU Phosphoramidite- 13C2,d1 (DMT-2'O-TBDMS-rU phosphoramidite- 13C2,d1) is deuterium and 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-101981S1
-
5'-Uridylic acid-<sup>15sup>N2,d11 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate- 15N2,d11 (5'-?Uridylic acid- 15N2,d11) dilithium is deuterium and 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-W393970S
-
5'-Deoxyguanylic acid-<sup>15sup>N5,d12 dilithium
|
Isotope-Labeled Compounds
|
Others
|
2′-Deoxyguanosine 5′-monophosphate- 15N5,d12 (5'-Deoxyguanylic acid- 15N5,d12) dilithium is deuterium and 15N labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
|
-
- HY-12650S
-
DS5565-<sup>13sup>C2,d1 (Mixture of Diastereomers)
|
Isotope-Labeled Compounds
|
Others
|
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS .
|
-
- HY-110189S
-
3β-Hydroxy-5-pregnen-20-one monosulfate (sodium)-<sup>13sup>C2,d2
|
Cannabinoid Receptor
TRP Channel
Endogenous Metabolite
Autophagy
|
Neurological Disease
|
Pregnenolone monosulfate (sodium)- 13C2,d2 is the 13C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
|
-
- HY-W156840S
-
ethanone, 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-<sup>13sup>C3
|
Isotope-Labeled Compounds
|
Others
|
OTNE- 13C3 is 13C labeled 2-methoxy-4-propylphenol.
|
-
- HY-W249257
-
-
- HY-W440240
-
-
- HY-W441174
-
-
- HY-P3350
-
|
Bacterial
|
Infection
|
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].
|
-
- HY-W005541S1
-
B-(3-Ethylphenyl)-Boronic acid-d5
|
Isotope-Labeled Compounds
|
Others
|
3-Ethylphenylboronic acid-d5 (B-(3-Ethylphenyl)-Boronic acid-d5) is a deuterium labeled 3-Ethylphenylboronic acid.
|
-
- HY-41417SR
-
Caprylic acid-d15 (Standard)
|
Endogenous Metabolite
|
Metabolic Disease
|
Octanoic acid-d15 (Standard) is the analytical standard of Octanoic acid-d15. This product is intended for research and analytical applications. Octanoic acid-d15 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-113308S
-
-
- HY-113308S1
-
-
- HY-12769S1
-
-
- HY-B0172S1
-
-
- HY-154788S
-
-
- HY-18569S
-
Indole-3-acetic acid-d5; 3-IAA-d5
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Others
|
3-Indoleacetic acid-d5 is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid-d5 can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates[1].
|
-
- HY-W010255S
-
Benzoylformic acid-d5
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Phenylglyoxylic acid-d5 (Benzoylformic acid-d5) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human .
|
-
- HY-78327AS
-
-
- HY-N0384S4
-
Vanilacetic acid-d3-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency .
|
-
- HY-B1899BS
-
-
- HY-113335S
-
-
- HY-121238S1
-
-
- HY-132446S
-
-
- HY-76353S
-
-
- HY-139417S
-
-
- HY-122141S
-
-
- HY-133813S
-
-
- HY-125731S1
-
-
- HY-125731S
-
-
- HY-121238S
-
-
- HY-N7833S
-
-
- HY-115340S
-
-
- HY-132464S1
-
-
- HY-143924S
-
-
- HY-143994S
-
-
- HY-N0830BS2
-
-
- HY-N0830BS3
-
-
- HY-111973S3
-
-
- HY-B1053S
-
-
- HY-B1899S1
-
-
- HY-W010255AS
-
Benzoylformic acid-d5 sodium; Sodium phenylglyoxylate-d5
|
Isotope-Labeled Compounds
|
Others
|
Phenylglyoxylic acid-d5 (sodium) is the deuterium labeled Phenylglyoxylic acid (sodium)[1].
|
-
- HY-W105832S
-
-
- HY-Y0001S
-
-
- HY-Y1150S2
-
-
- HY-P10218A
-
|
PKC
|
Inflammation/Immunology
Cancer
|
MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
|
-
- HY-P10218
-
|
PKC
|
Inflammation/Immunology
Cancer
|
MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
|
-
- HY-B0302AS
-
-
- HY-12769S
-
-
- HY-12771S1
-
-
- HY-12771S
-
-
- HY-121950S
-
-
- HY-12771S2
-
-
- HY-N0305S1
-
-
- HY-139483S
-
-
- HY-131314S
-
-
- HY-W141770S
-
-
- HY-W012738S
-
-
- HY-W141770S1
-
-
- HY-N1481S
-
-
- HY-113328S
-
|
Endogenous Metabolite
|
Others
|
Aminoadipic acid-d3 is the deuterium labeled Aminoadipic acid. Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine.
|
-
- HY-W018790S
-
-
- HY-W035361S
-
-
- HY-W099438S
-
-
- HY-Y0069S1
-
Aceturic acid-d2; Acetamidoacetic acid-d2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
N-Acetylglycine-d2 (Aceturic acid-d2; Acetamidoacetic acid-d2) is the deuterated labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
|
-
- HY-109590S1
-
-
- HY-146713S
-
-
- HY-W012791S1
-
-
- HY-W103882S
-
-
- HY-W002071S
-
-
- HY-W010590S
-
-
- HY-Y0267S
-
-
- HY-Y1009S
-
-
- HY-W702637
-
-
- HY-113295S3
-
-
- HY-107494S2
-
-
- HY-141749S
-
-
- HY-B1788S
-
N-Choloyltaurine-d4 (sodium)
|
Endogenous Metabolite
|
Inflammation/Immunology
|
Taurocholic acid-d4 (sodium) is the deuterium labeled Taurocholic acid. Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
|
-
- HY-131620S
-
-
- HY-124350S
-
-
- HY-133707S1
-
-
- HY-W004283S1
-
|
Endogenous Metabolite
|
Others
|
Pentadecanoic acid-d3 is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.
|
-
- HY-133890AS
-
-
- HY-B0172S
-
-
- HY-113099S
-
Indole-3-lactic acid-d5
|
Endogenous Metabolite
|
Others
|
Indolelactic acid-d5 is the deuterium labeled Indolelactic acid. Indolelactic acid is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures.
|
-
- HY-W127329S
-
-
- HY-133707S
-
-
- HY-125138S
-
-
- HY-W004283S
-
|
Endogenous Metabolite
|
Others
|
Pentadecanoic acid-d29 is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.
|
-
- HY-B1788S1
-
-
- HY-W004283S2
-
|
Endogenous Metabolite
|
|
Pentadecanoic acid-d2 is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.
|
-
- HY-W154267S
-
-
- HY-Y1315S
-
-
- HY-150718S
-
-
- HY-78571S
-
-
- HY-I0746S
-
-
- HY-W015333S
-
-
- HY-W032375S
-
-
- HY-W220946S
-
-
- HY-W245465
-
-
- HY-Y0607S1
-
-
- HY-Y1027S2
-
-
- HY-Y1115S
-
-
- HY-Y1138S
-
-
- HY-Y1313S
-
m-Carboxynitrobenzene-d4; m-Nitrobenzenecarboxylic acid-d4; m-Nitrobenzoic acid-d4
|
Isotope-Labeled Compounds
|
Others
|
3-Nitrobenzoic acid-d4 is the deuterium labeled 3-Nitrobenzoic acid[1].
|
-
- HY-B0421S
-
-
- HY-W013049S1
-
-
- HY-41912AS
-
-
- HY-W012709S
-
-
- HY-W013049S3
-
-
- HY-100560S
-
(S)-(+)-Abscisic acid-d6; ABA-d6
|
Proton Pump
|
Metabolic Disease
|
Abscisic acid-d6 is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H+-ATPase)[1].
|
-
- HY-21323S
-
-
- HY-W016473S
-
-
- HY-113328S1
-
|
Isotope-Labeled Compounds
|
Others
|
Aminoadipic acid-d6 is deuterated labeled Aminoadipic acid (HY-113328). Aminoadipic acid is an intermediate in the metabolism of lysine and glycopurine.
|
-
- HY-B0660S
-
-
- HY-139610S1
-
-
- HY-W015924S
-
-
- HY-131619S
-
-
- HY-B0515AS1
-
|
Apoptosis
Isotope-Labeled Compounds
|
Cancer
|
Ibandronic acid-d3 is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
|
-
- HY-109590S2
-
-
- HY-109590S
-
-
- HY-139924S
-
-
- HY-W012583S
-
-
- HY-W013049S4
-
-
- HY-113524S
-
-
- HY-W012791S
-
-
- HY-W013049S5
-
-
- HY-113482S
-
-
- HY-W014633S
-
-
- HY-143860S
-
-
- HY-150664S
-
-
- HY-41463S
-
4-(Butylamino)benzoic acid-d7; NSC 44300-d7; p-Butylaminobenzoic acid-d7
|
Isotope-Labeled Compounds
|
Others
|
4-(Butylamino)benzoic acid-d7 is the deuterium labeled 4-(Butylamino)benzoic acid[1].
|
-
- HY-75968S
-
-
- HY-N0216BS
-
-
- HY-W012507S
-
-
- HY-W012510S
-
-
- HY-W015139S
-
-
- HY-W015496S
-
-
- HY-W015881S
-
-
- HY-W018728S
-
-
- HY-W039173S
-
4-(Methylamino)butyric acid-d9 hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
4-(Methylamino)butanoic acid-d9 hydrochloride is the deuterium labeled 4-(Methylamino)butanoic acid hydrochloride[1].
|
-
- HY-W091636S
-
3,3'-Iminodipropionic acid-d8
|
Isotope-Labeled Compounds
|
Others
|
3,3'-Azanediyldipropionic acid-d8 is the deuterium labeled 3,3'-Azanediyldipropionic acid[1].
|
-
- HY-Y0957S
-
-
- HY-W002068S
-
-
- HY-W710495
-
-
- HY-B0760S
-
|
PPAR
COX
|
Metabolic Disease
|
Fenofibric acid-d6 (FNF acid-d6) is the deuterium labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
|
-
- HY-139610S
-
-
- HY-W015967S
-
-
- HY-113353S
-
|
Endogenous Metabolite
|
Others
|
Nicotinuric acid-d4 is the deuterium labeled Nicotinuric acid. Nicotinuric acid is an acyl glycine. Nicotinuric acid is a metabolite of nicotinic acid[1][2].
|
-
- HY-113308AS
-
-
- HY-W011713S
-
-
- HY-Y1176S
-
-
- HY-76847S
-
-
- HY-N0420S
-
Wormwood acid-d6
|
Endogenous Metabolite
|
Metabolic Disease
|
Succinic acid-d6 is the deuterium labeled Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.
|
-
- HY-113308AS1
-
|
Calcium Channel
|
Metabolic Disease
|
Taurolithocholic Acid-d5 (sodium) is the deuterium labeled Taurolithocholic acid sodium salt. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1][2].
|
-
- HY-76847S1
-
-
- HY-113327S
-
-
- HY-W011873S
-
-
- HY-100805S
-
-
- HY-W011873S1
-
|
Endogenous Metabolite
|
Neurological Disease
|
Palmitoleic acid-d13 is the deuterium labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.
|
-
- HY-76847S3
-
-
- HY-113308AS2
-
-
- HY-B2219S8
-
-
- HY-W001942S1
-
-
- HY-W001955S
-
-
- HY-W007872S
-
-
- HY-W017763S
-
-
- HY-W131158S
-
-
- HY-W282887S
-
-
- HY-Y0001S1
-
-
- HY-Y0839S
-
4-Oxovaleric acid-d5; NSC 3716-d5
|
Endogenous Metabolite
|
Others
|
Levulinic acid-d5 is the deuterium labeled Levulinic acid[1]. Levulinic acid is a precursor for the synthesis of biofuels, such as ethyl levulinate[2].
|
-
- HY-Y1373S
-
|
Endogenous Metabolite
|
Neurological Disease
|
Cyclohexanecarboxylic acid-d1 is the deuterium labeled Cyclohexanecarboxylic acid[1]. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action[2].
|
-
- HY-Y1373S1
-
|
Endogenous Metabolite
|
Neurological Disease
|
Cyclohexanecarboxylic acid-d11 is the deuterium labeled Cyclohexanecarboxylic acid[1]. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action[2].
|
-
- HY-161008S
-
-
- HY-W028943S
-
(2E)-3-Methyl-2-hexenoic acid-d5
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
(E)-3-Methyl-2-hexenoic acid-d5 ((2E)-3-Methyl-2-hexenoic acid-d5) is a deuterium labeled (E)-3-Methyl-2-hexenoic acid. (E)-3-Methyl-2-hexenoic acid is an axillary odor-related compound .
|
-
- HY-B0515AS
-
|
Apoptosis
Isotope-Labeled Compounds
|
Cancer
|
Ibandronic Acid-d3 (sodium) is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis[1][2].
|
-
- HY-W012980S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Isovaleric acid-d9 is the deuterium labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human.
|
-
- HY-34740S
-
-
- HY-103395S
-
Methylpropanedioic acid-d3; Methylmalonate-d3
|
Endogenous Metabolite
|
Cancer
|
Methylmalonic acid-d3 is the deuterium labeled Methylmalonic acid. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer[1][2].
|
-
- HY-B0149S
-
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
Tranexamic acid-d2 is the deuterium labeled Tranexamic acid. Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments.
|
-
- HY-34740S1
-
-
- HY-113411S
-
|
Endogenous Metabolite
|
Others
|
3-Hydroxyglutaric acid-d5 is the deuterium labeled 3-Hydroxyglutaric acid. 3-Hydroxyglutaric acid is a glutaric acid derivative[1][2].
|
-
- HY-70002BS
-
-
- HY-N0666S2
-
-
- HY-N0666S8
-
-
- HY-W206016S
-
-
- HY-N1446S5
-
-
- HY-W016456S
-
-
- HY-B0148S
-
|
Isotope-Labeled Compounds
|
Others
|
Risedronic Acid-d4 is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption[1][2].
|
-
- HY-N1428S
-
-
- HY-W013826S
-
-
- HY-B1008S
-
PABA-d4; Vitamin Bx-d4; Vitamin H1-d4; p-Aminobenzoic acid-d4
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
4-Aminobenzoic acid-d4 is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.
|
-
- HY-W013826S1
-
-
- HY-W010098S
-
|
Endogenous Metabolite
|
Others
|
Terephthalic acid-d4 is the deuterium labeled Terephthalic acid. Terephthalic acid is one isomer of the three phthalic, a precursor to the polyester PET, used to make clothing and plastic bottles.
|
-
- HY-B2219S3
-
-
- HY-116752S
-
-
- HY-B2219S1
-
-
- HY-106579S
-
|
COX
|
Inflammation/Immunology
|
Tiaprofenic acid-d3 is a deuterium labeled Tiaprofenic acid. Tiaprofenic acid is a nonsteroidal anti-inflammatory agent (NSAID) mainly used in the treatment of rheumatic diseases[1].
|
-
- HY-B2219S4
-
-
- HY-125140S
-
-
- HY-B2219S6
-
-
- HY-113301S1
-
|
Endogenous Metabolite
|
Cardiovascular Disease
|
Hexacosanoic acid-d4-11 is the deuterium labeled Hexacosanoic acid. Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis.
|
-
- HY-B2219S9
-
|
Endogenous Metabolite
|
|
Stearic acid-d7 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
|
-
- HY-W002094S
-
-
- HY-W040287S
-
-
- HY-W056964S
-
Naphthalene-2,6-dicarboxylate-d6
|
Isotope-Labeled Compounds
|
Others
|
Naphthalene-2,6-dicarboxylic acid-d6 is the deuterium labeled Naphthalene-2,6-dicarboxylic acid[1].
|
-
- HY-W188178S
-
-
- HY-Y1088S1
-
|
Endogenous Metabolite
|
Others
|
Hydrocinnamic acid-d2 is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities[2].
|
-
- HY-Y1088S3
-
3-Phenylpropionic acid-d5; 3-Phenylpropanoic acid-d5; 3-Phenyl-n-propionic acid-d5
|
Endogenous Metabolite
|
Others
|
Hydrocinnamic acid-d5 is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities[2].
|
-
- HY-Y1139S
-
Heptanedioic acid-d4; 1,5-Pentanedicarboxylic acid-d4; 1,7-Heptanedioic acid-d4
|
Endogenous Metabolite
|
Metabolic Disease
|
Pimelic acid-d4 is the deuterium labeled Pimelic acid[1]. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.
|
-
- HY-157568S
-
|
Isotope-Labeled Compounds
|
Others
|
Budesonide acid-d8 is a deuterium labeled Budesonide acid. Budesonide acid is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist .
|
-
- HY-Y0262S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Oxalic Acid-d2 is the deuterium labeled Oxalic Acid. Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
|
-
- HY-126061S
-
-
- HY-W001080S
-
|
Endogenous Metabolite
|
Others
|
3,4-Dihydroxybenzeneacetic acid-d5 is the deuterium labeled 3,4-Dihydroxybenzeneacetic acid. 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.
|
-
- HY-W015882S
-
Isocaproic acid-d12
|
Isotope-Labeled Compounds
|
Others
|
4-Methylpentanoic acid-d12 is the deuterium labeled 4-Methylpentanoic acid. 4-Methylpentanoic acid (Isocaproic Acid) is a Short chain fatty acid (SCFA)[1].
|
-
- HY-W016825S1
-
-
- HY-133972S
-
-
- HY-113220S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Monoisobutyl phthalic acid-d4 is the deuterium labeled Monoisobutyl phthalic acid[1]. Monoisobutyl phthalic acid is a phthalate metabolite that is in human semen and in meconium[2].
|
-
- HY-N0339S
-
-
- HY-Y0367S
-
Maleic-2,3-d2 acid
|
Bacterial
Endogenous Metabolite
|
Infection
|
Maleic Acid-d2 is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].
|
-
- HY-N0156S
-
Oleanic acid-d3; Caryophyllin-d3
|
Autophagy
HIV
Endogenous Metabolite
|
Cancer
|
Oleanolic acid-d3 is the deuterium labeled Oleanolic Acid[1]. Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities[2].
|
-
- HY-N0324S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Cholic acid-d4 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
|
-
- HY-141721S
-
-
- HY-W009973S
-
-
- HY-N0324S1
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Cholic acid-d5 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
|
-
- HY-132800S
-
-
- HY-115433S1
-
-
- HY-125774S
-
-
- HY-135400S
-
|
FXR
|
Inflammation/Immunology
|
Glyco-obeticholic acid-d5 is the deuterium labeled Glyco-Obeticholic acid. Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist[1].
|
-
- HY-115433S
-
-
- HY-135399S
-
|
FXR
|
Inflammation/Immunology
|
Tauro-obeticholic acid-d5 sodium is deuterium labeled Tauro-obeticholic acid. Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist.
|
-
- HY-B2219S7
-
-
- HY-N2041S5
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
|
Myristic acid-d is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
|
-
- HY-W016342S
-
-
- HY-W143303S
-
-
- HY-142907S
-
-
- HY-78985S
-
-
- HY-B0541S
-
|
Isotope-Labeled Compounds
|
Others
|
Cyclamic Acid-d11 is the deuterium labeled Cyclamic acid[1]. Cyclamic acid (Cyclohexylsulfamic acid) is one of the most widely used artificial sweetenersin food and pharmaceuticals[2].
|
-
- HY-W012241S
-
|
Endogenous Metabolite
|
Others
|
Dodecanedioic acid-d20 is the deuterium labeled Dodecanedioic acid[1]. Dodecanedioic acid (C12) is a dicarboxylic acid with a metabolic pathway intermediate to those of lipids and carbohydrates[2].
|
-
- HY-W012241S1
-
|
Endogenous Metabolite
|
Others
|
Dodecanedioic acid-d4 is the deuterium labeled Dodecanedioic acid[1]. Dodecanedioic acid (C12) is a dicarboxylic acid with a metabolic pathway intermediate to those of lipids and carbohydrates[2].
|
-
- HY-W015883S3
-
|
Endogenous Metabolite
|
|
Fumaric acid-d2 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
|
-
- HY-W015883S4
-
|
Endogenous Metabolite
|
|
Fumaric acid-d4 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
|
-
- HY-Y1088S2
-
3-Phenylpropionic acid-d9; 3-Phenylpropanoic acid-d9; 3-Phenyl-n-propionic acid-d9
|
Endogenous Metabolite
|
Others
|
Hydrocinnamic acid-d9 is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activitie[2]s.
|
-
- HY-N1423S1
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
Glycocholic acid-d5 is the deuterium labeled Glycocholic acid. Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways .
|
-
- HY-18569S1
-
Indole-3-acetic acid-d4; 3-IAA-d4
|
Isotope-Labeled Compounds
|
Others
|
3-Indoleacetic acid-d4 (Indole-3-acetic acid-d4; 3-IAA-d4)is the deuterium labeled3-Indoleacetic acid(HY-18569) . 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
|
-
- HY-W015060S1
-
|
Endogenous Metabolite
|
Others
|
2-(2-Methylbenzamido)acetic acid-d2 is the deuterium labeled 2-(2-Methylbenzamido)acetic acid. 2-(2-Methylbenzamido)acetic acid is a metabolite detected in urine.
|
-
- HY-W015229S
-
-
- HY-N1423S
-
|
Endogenous Metabolite
|
Cancer
|
Glycocholic acid-d4 is the deuterium labeled Glycocholic acid. Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].
|
-
- HY-W015060S
-
|
Endogenous Metabolite
|
Others
|
2-(2-Methylbenzamido)acetic acid-d7 is the deuterium labeled 2-(2-Methylbenzamido)acetic acid. 2-(2-Methylbenzamido)acetic acid is a metabolite detected in urine.
|
-
- HY-N2341S
-
|
AMPK
PPAR
Glucokinase
|
Metabolic Disease
|
Palmitelaidic acid-d13 is the deuterium labeled Palmitelaidic Acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
|
-
- HY-113455S
-
-
- HY-76082S
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
|
L-Pyroglutamic acid-d5 is the deuterium labeled L-Pyroglutamic acid. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
|
-
- HY-N9933S
-
T-βMCA-d4-1 sodium
|
Isotope-Labeled Compounds
|
Others
|
Tauro-β-muricholic acid-d4-1 (T-βMCA-d4-1) sodiumis the deuterium labeledTauro-β-muricholic acid(HY-N9933) .
|
-
- HY-P10200
-
|
Bacterial
|
Infection
|
CP7-FP13-2 is a peptide with antivirulence factor and antibacterial activity. CP7-FP13-2 inhibits the formation of Staphylococcus aureus biofilm and has good antibacterial efficacy in mice .
|
-
- HY-Y1311S
-
Hydroxybutanedioic acid-d3; E 296-d3
|
Endogenous Metabolite
|
Others
|
Malic acid-d3 is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods[1][2].
|
-
- HY-N0384S2
-
Vanilacetic acid-d5
|
Endogenous Metabolite
|
Metabolic Disease
|
Homovanillic acid-d5 is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
|
-
- HY-N0384S
-
Vanilacetic acid-d3
|
Endogenous Metabolite
|
Metabolic Disease
|
Homovanillic acid-d3 is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
|
-
- HY-16637S1
-
-
- HY-W013425S
-
-
- HY-N0384S1
-
Vanilacetic acid-d2
|
Endogenous Metabolite
|
Metabolic Disease
|
Homovanillic acid-d2 is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
|
-
- HY-N1424S
-
|
Endogenous Metabolite
|
Neurological Disease
|
Glycoursodeoxycholic acid-d4 (Ursodeoxycholylglycine-d4) is the deuterium labeled Glycoursodeoxycholic acid. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid[1][2].
|
-
- HY-145003S
-
-
- HY-41417S1
-
Caprylic acid-d3
|
Endogenous Metabolite
|
Metabolic Disease
|
Octanoic acid-d3 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-41417S2
-
Caprylic acid-d2
|
Endogenous Metabolite
|
Metabolic Disease
|
Octanoic acid-d2 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-41417S
-
Caprylic acid-d15
|
Endogenous Metabolite
|
Metabolic Disease
|
Octanoic acid-d15 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-N2041S3
-
|
Endogenous Metabolite
|
Others
|
Myristic acid-d33 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
|
-
- HY-N2041S
-
|
Endogenous Metabolite
|
Others
|
Myristic acid-d27 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
|
-
- HY-B0172AS
-
-
- HY-N2041S1
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
|
Myristic acid-d2 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
|
-
- HY-N2041S6
-
|
Endogenous Metabolite
|
|
Myristic acid-d5 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
|
-
- HY-N2041S7
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
|
Myristic acid-d7 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
|
-
- HY-W004261S
-
|
Endogenous Metabolite
|
|
Nonadecanoic acid-d37 is the deuterium labeled Nonadecanoic acid. Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis to defence[1].
|
-
- HY-Y0127S
-
-
- HY-143854S
-
-
- HY-148677S
-
-
- HY-113301S
-
|
Endogenous Metabolite
|
Cardiovascular Disease
|
Hexacosanoic acid-d4 is the deuterium labeled Hexacosanoic acid[1]. Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis[2].
|
-
- HY-W012980S2
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Isovaleric acid-d2 is the deuterium labeled Isovaleric acid[1]. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human[2].
|
-
- HY-W012980S3
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Isovaleric acid-d7 is the deuterium labeled Isovaleric acid[1]. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human[2].
|
-
- HY-W014666S
-
|
Apoptosis
mGluR
Endogenous Metabolite
|
|
Xanthurenic acid-d4 is the deuterium labeled Xanthurenic acid[1]. Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus[2].
|
-
- HY-W015300S
-
Octanedioic acid-d4
|
Endogenous Metabolite
|
Metabolic Disease
|
Suberic acid-d4 is the deuterium labeled Suberic acid[1]. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency[2].
|
-
- HY-W015300S1
-
Octanedioic acid-d12
|
Endogenous Metabolite
|
Metabolic Disease
|
Suberic acid-d12 is the deuterium labeled Suberic acid[1]. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency[2].
|
-
- HY-W015882S1
-
|
Isotope-Labeled Compounds
|
Others
|
4-Methylpentanoic acid-d11 is the deuterium labeled 4-Methylpentanoic acid[1]. 4-Methylpentanoic acid (Isocaproic Acid) is a Short chain fatty acid (SCFA)[2].
|
-
- HY-W016825S
-
-
- HY-W016825S2
-
-
- HY-W030778S
-
|
Isotope-Labeled Compounds
|
Others
|
Nitrilotriacetic acid-d9 is the deuterium labeled Nitrilotriacetic acid[1]. Nitrilotriacetic acid is an aminotricarboxylic acid. Nitrilotriacetic acid can be used as a chelating agent, forming coordination compounds with metal ions[2].
|
-
- HY-W087940S
-
-
- HY-N0593S1
-
-
- HY-W016562S1
-
2-Benzamidoacetic acid-d2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
Hippuric acid-d2 is the deuterium labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
|
-
- HY-113493S1
-
|
Endogenous Metabolite
|
Metabolic Disease
|
4-Pyridoxic acid-d3 is the deuterium labeled 4-Pyridoxic acid. 4-Pyridoxic acid is a catabolic product of vitamin B6 which is excreted in the urine[1][2].
|
-
- HY-N0593S2
-
-
- HY-W016562S
-
2-Benzamidoacetic acid-d5
|
Endogenous Metabolite
|
Metabolic Disease
|
Hippuric acid-d5 is the deuterium labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
|
-
- HY-N0610AS
-
3-Phenylacrylic acid-d6; β-Phenylacrylic acid-d6
|
Endogenous Metabolite
|
Cancer
|
Cinnamic acid-d6 is the deuterium labeled Cinnamic acid. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.
|
-
- HY-B0167S
-
-
- HY-N1446S3
-
-
- HY-N0593S
-
-
- HY-N1446S1
-
-
- HY-75087S
-
-
- HY-W004282S
-
Undecanoate-d21; Hendecanoic acid-d21
|
Fungal
Endogenous Metabolite
|
Cancer
|
Undecanoic acid-d21 is the deuterium labeled Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum[1].
|
-
- HY-W004282S1
-
Undecanoate-d3; Hendecanoic acid-d3
|
Fungal
Endogenous Metabolite
|
|
Undecanoic acid-d3 is the deuterium labeled Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum[1].
|
-
- HY-W004282S2
-
Undecanoate-d2; Hendecanoic acid-d2
|
Fungal
Endogenous Metabolite
|
|
Undecanoic acid-d2 is the deuterium labeled Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum[1].
|
-
- HY-12357S2
-
ETC-1002-d4; ESP-55016-d4
|
ATP Citrate Lyase
AMPK
|
Others
|
Bempedoic acid-d4 is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].
|
-
- HY-B0704S
-
Nonanedioic acid-d14
|
Endogenous Metabolite
|
Others
|
Azelaic acid-d14 is the deuterium labeled Azelaic acid[1]. Azelaic acid is an organic compound produced by the ozonolysis of oleic acid;component of a number of hair and skin conditioners[2][3].
|
-
- HY-W002011S
-
-
- HY-W015175S
-
|
Isotope-Labeled Compounds
|
Others
|
p-Toluenesulfonic acid-d7 (monohydrate) is the deuterium labeled p-Toluenesulfonic acid monohydrate[1]. p-Toluenesulfonic acid monohydrate, a strong organic acid, acts as organic catalyst used in organic synthesis[2][3].
|
-
- HY-B1306S
-
p-Aminohippuric acid-d4
|
Endogenous Metabolite
|
Others
|
4-Aminohippuric acid-d4 is the deuterium labeled 4-Aminohippuric acid. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow.
|
-
- HY-108398AS
-
5,8,11-Eicosatrienoic acid-d6
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
Mead acid-d6 is the deuterium labeled Mead acid. Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency[1].
|
-
- HY-101541S
-
Methyl docosahexaenoate-d5; all cis-DHA methyl ester-d5
|
Isotope-Labeled Compounds
|
Neurological Disease
|
Docosahexaenoic acid-d5 methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed[1][2].
|
-
- HY-N1394S1
-
4-Methoxybenzoic acid-d4; Draconic acid-d4
|
Bacterial
Endogenous Metabolite
|
Infection
|
p-Anisic acid-d4 is the deuterium labeled p-Anisic acid[1]. p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties[2].
|
-
- HY-W280618S
-
-
- HY-Y0771S
-
|
Endogenous Metabolite
|
Others
|
3,4-Dimethoxyphenylacetic acid-d2 is the deuterium labeled 3,4-Dimethoxyphenylacetic acid[1]. 3,4-Dimethoxyphenylacetic acid is a building block in the chemical synthesis[2].
|
-
- HY-P0041A
-
-
- HY-B0493S
-
|
Chloride Channel
|
Inflammation/Immunology
|
Niflumic Acid-d5 is the deuterium labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis[1][2].
|
-
- HY-A0281S
-
4-PBA-d11; Benzenebutyric acid-d11
|
HDAC
Virus Protease
|
Infection
Cancer
|
4-Phenylbutyric acid-d11 is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
|
-
- HY-W015309S
-
|
iGluR
|
Neurological Disease
|
Decanoic acid-d3 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects[1][2][3].
|
-
- HY-N0169S
-
-
- HY-B2167S
-
DHA-d5; Cervonic acid-d5
|
Endogenous Metabolite
|
Neurological Disease
|
Docosahexaenoic acid-d5 is the deuterium labeled Docosahexaenoic Acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
|
-
- HY-W015309S2
-
|
iGluR
|
Neurological Disease
|
Decanoic acid-d2 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects[1][2][3].
|
-
- HY-W015309S1
-
|
iGluR
|
Neurological Disease
|
Decanoic acid-d199 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects[1][2][3].
|
-
- HY-W014663S
-
|
Isotope-Labeled Compounds
|
Others
|
(S)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid-d3 is the deuterium labeled (S)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid.
|
-
- HY-W015309S3
-
|
iGluR
|
|
Decanoic acid-d5 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects[1][2][3].
|
-
- HY-N0351S1
-
trans-4-Hydroxycinnamic acid-d6
|
Endogenous Metabolite
|
Cancer
|
p-Coumaric acid-d6 is the deuterium labeled p-Coumaric acid (HY-N0351). p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities[1][2].
|
-
- HY-41417S6
-
Caprylic acid-d5
|
Endogenous Metabolite
|
Metabolic Disease
|
Octanoic acid-d5 is the deuterium labeled Octanoic acid[1]. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-W014787S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Decanedioic acid-d4 is the deuterium labeled Decanedioic acid[1]. Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[2].
|
-
- HY-W014787S1
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Decanedioic acid-d16 is the deuterium labeled Decanedioic acid[1]. Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[2].
|
-
- HY-P3462
-
|
CGRP Receptor
|
Metabolic Disease
|
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity .
|
-
- HY-P3462A
-
|
CGRP Receptor
|
Metabolic Disease
|
Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies .
|
-
- HY-P5161A
-
|
GCGR
|
Metabolic Disease
|
FC382K10W15 TFA is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 TFA can be used in type 2 diabetes research .
|
-
- HY-105168
-
|
Endothelin Receptor
|
Cardiovascular Disease
|
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .
|
-
- HY-122464S2
-
|
Isotope-Labeled Compounds
|
Others
|
(±)-Jasmonic acid-d5 is the deuterium labeled (±)-Jasmonic acid. (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.
|
-
- HY-122464S1
-
|
Isotope-Labeled Compounds
|
Others
|
Jasmonic acid-d5 is deuterium labeled (±)-Jasmonic acid. (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.
|
-
- HY-30004S
-
-
- HY-Y0669S
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
Bacterial
|
|
Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid, a metabolite of Lysine, is an important precursor of many useful microbial secondary metabolites. Pipecolic acid can be used as a diagnostic marker of Pyridoxine-dependent epilepsy[1][2].
|
-
- HY-113247S1
-
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
trans-trans-Muconic acid-d4-1 is a deuterium labeled trans-trans-Muconic acid (HY-113247). trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.
|
-
- HY-W393970S1
-
5'-Deoxyguanylic acid-d12 dilithium
|
Isotope-Labeled Compounds
|
Others
|
2′-Deoxyguanosine 5′-monophosphate-d12 (5'-Deoxyguanylic acid-d12) dilithium is deuterium labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
|
-
- HY-101411S
-
-
- HY-W018161S
-
|
Endogenous Metabolite
|
Others
|
Hexadecanedioic acid-d28 is the deuterium labeled Hexadecanedioic acid. Hexadecanedioic acid is covalently linked to Sepharose 4B, shows better performance in terms of specificity than dye-based resins and could be used for depletion of SA from plasma samples.
|
-
- HY-W008820S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Glutaric acid-d6 is the deuterium labeled Glutaric acid. Glutaric acid is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
|
-
- HY-Y0264S1
-
|
Endogenous Metabolite
Bacterial
|
Infection
|
4-Hydroxybenzoic acid-d4 is the deuterium labeled 4-Hydroxybenzoic acid. 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.
|
-
- HY-Y0366S3
-
-
- HY-Y0366S1
-
|
Endogenous Metabolite
Bacterial
|
Infection
|
Lauric acid-d233 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
|
-
- HY-101108S
-
AGN 190299-d6
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
Tazarotenic acid-d6 is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .
|
-
- HY-N0180S
-
|
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
18β-Glycyrrhetinic acid-d3 is deuterium labeled 18β-Glycyrrhetinic acid. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
|
-
- HY-Y0366S2
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
Bacterial
|
|
Lauric acid-d2 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
|
-
- HY-Y0366S5
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
Bacterial
|
|
Lauric acid-d5 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
|
-
- HY-113019S
-
-
- HY-146773S
-
-
- HY-146793S
-
-
- HY-113247S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
trans-trans-Muconic acid-d4 is the deuterium labeled trans-trans-Muconic acid[1]. trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human[2].
|
-
- HY-12357S
-
ETC-1002-d5; ESP-55016-d5
|
ATP Citrate Lyase
AMPK
|
Metabolic Disease
|
Bempedoic acid-d5 is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].
|
-
- HY-41494S
-
2-Methylbenzoic acid-d7
|
Endogenous Metabolite
|
Others
|
O-Toluic acid-d7 is the deuterium labeled o-Toluic acid[1]. o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.
|
-
- HY-76547S
-
4-Methylbenzoic acid-d4
|
Endogenous Metabolite
|
Others
|
p-Toluic acid-d4 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
|
-
- HY-76547S1
-
4-Methylbenzoic acid-d7
|
Endogenous Metabolite
|
Others
|
p-Toluic acid-d7 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
|
-
- HY-76547S2
-
4-Methylbenzoic acid-d3
|
Endogenous Metabolite
|
Others
|
p-Toluic acid-d3 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
|
-
- HY-B0149S1
-
|
Isotope-Labeled Compounds
|
|
Tranexamic acid-d2-1 is the deuterium labeled Tranexamic acid[1]. Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM[2][3].
|
-
- HY-W004515S
-
|
Endogenous Metabolite
|
Others
|
3-Pyridylacetic acid-d4 (hydrochloride) is the deuterium labeled 3-Pyridylacetic acid hydrochloride[1]. 3-Pyridineacetic acid hydrochloride is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids)[2][3].
|
-
- HY-N1429S
-
12-Deoxycholyltaurine-d9 sodium
|
Isotope-Labeled Compounds
Apoptosis
Endogenous Metabolite
|
Inflammation/Immunology
|
Taurochenodeoxycholic acid-d9 (sodium) is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
|
-
- HY-141745S
-
|
Isotope-Labeled Compounds
|
Others
|
2-(((4-Methyl-7-oxooctyl)oxy)carbonyl)benzoic acid-d4 is the deuterium labeled 2-(((4-Methyl-7-oxooctyl)oxy)carbonyl)benzoic acid[1].
|
-
- HY-N2334AS
-
Chenodeoxycholylglycine-d7 (sodium); Sodium glycochenodeoxycholate-d7
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
Glycochenodeoxycholic acid-d7 (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].
|
-
- HY-N1429S1
-
12-Deoxycholyltaurine-d5 (sodium)
|
Apoptosis
Endogenous Metabolite
|
Inflammation/Immunology
|
Taurochenodeoxycholic acid-d5 (sodium) is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
|
-
- HY-N2334S
-
Chenodeoxycholylglycine-d4
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
Glycochenodeoxycholic acid-d4 is the deuterium labeled Glycochenodeoxycholic acid. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis[1][2].
|
-
- HY-N2027S
-
12-Deoxycholyltaurine-d4 sodium
|
Isotope-Labeled Compounds
Apoptosis
Endogenous Metabolite
|
Inflammation/Immunology
|
Taurochenodeoxycholic acid-d4 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
|
-
- HY-113427AS
-
|
Antibiotic
|
Cancer
|
cis-Vaccenic acid-d13 is the deuterium labeled cis-Vaccenic acid. cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].
|
-
- HY-A0281S3
-
4-PBA-d2; Benzenebutyric acid-d2
|
HDAC
Virus Protease
|
|
4-Phenylbutyric acid-d2 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
|
-
- HY-W010381S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
2-Methylsuccinic acid-d6 is the deuterium labeled 2-Methylsuccinic acid[1]. 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy[2][3].
|
-
- HY-P10271
-
|
GLP Receptor
|
Metabolic Disease
|
RG7697 is a dual agonist for glucagon-like peptide receptor (GLP Receptor) and glucosedependent insulinotropic polypeptide receptor (GIPR), with EC50 of 5 and 3 pM, respectively. RG7697 exhibits antihyperglycemic property .
|
-
- HY-113121S1
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
|
Vanillylmandelic acid-d is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].
|
-
- HY-Y1069S
-
(S)-Hydroxybutanedioic acid-d3; (S)-E 296-d3
|
Endogenous Metabolite
|
Metabolic Disease
|
(S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive[1][2].
|
-
- HY-B1415S
-
Chlorofibrinic acid-d4
|
PPAR
Drug Metabolite
|
Others
|
Clofibric acid-d4 is the deuterium labeled Clofibric acid. Clofibric acid (Chlorofibrinic acid), the pharmaceutically active metabolite of lipid regulators Clofibrate, Etofibrate and Etofyllinclofibrate, is a PPARα agonist which exhibits hypolipidemic effects. Clofibric acid also is an herbicide[1][2][3].
|
-
- HY-N1902S
-
|
Keap1-Nrf2
Endogenous Metabolite
|
Metabolic Disease
|
4-Hydroxyphenylacetic acid-d6 is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].
|
-
- HY-N1429S2
-
12-Deoxycholyltaurine-d4-1 sodium
|
Isotope-Labeled Compounds
Apoptosis
Endogenous Metabolite
|
|
Taurochenodeoxycholic acid-d4-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
|
-
- HY-W015240S
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
|
N-Acetyl-L-glutamic acid-d5 is the deuterium labeled N-Acetyl-L-glutamic acid. N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human[1].
|
-
- HY-N0216S
-
|
Bacterial
Fungal
Endogenous Metabolite
|
Infection
|
Benzoic acid-d5 is a deuterium substitute for Benzoic acid. Benzoic acid is an aromatic alcohol that occurs naturally in many plants and is a common additive in food, beverages, cosmetics and other products. Benzoic acid can act as a preservative by inhibiting bacteria and fungi[1][2].
|
-
- HY-B1619S
-
Cromoglicic acid-d5
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
Cromoglicic acid-d5 is the deuterium labeled Cromolyn[1]. Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis[2].
|
-
- HY-N0610S
-
trans-3-Phenylacrylic acid-d5
|
Bacterial
Endogenous Metabolite
|
|
trans-Cinnamic acid-d5 is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].
|
-
- HY-N0610S1
-
trans-3-Phenylacrylic acid-d7
|
Bacterial
Endogenous Metabolite
|
|
trans-Cinnamic acid-d7 is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].
|
-
- HY-W009713S
-
|
Drug Metabolite
|
Neurological Disease
|
(3,4,5-Trimethoxyphenyl)acetic-2,2 Acid-d2 is the deuterium labeled 3,4,5-Trimethoxyphenylacetic acid[1]. 3,4,5-Trimethoxyphenylacetic acid is a metabolite of Mescaline[2].
|
-
- HY-W008820S1
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Glutaric acid-d4 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
|
-
- HY-113378S
-
β-Hydroxybutyric acid-d4 (sodium)
|
Endogenous Metabolite
|
Metabolic Disease
|
3-Hydroxybutyric acid-d4 (sodium) is the deuterium labeled 3-Hydroxybutyric acid. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids[1].
|
-
- HY-W008820S2
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Glutaric acid-d2 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
|
-
- HY-16637S
-
-
- HY-I0508S
-
|
Isotope-Labeled Compounds
|
Others
|
Phthalic acid-d4 is the deuterium labeled Phthalic acid. Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers[1].
|
-
- HY-B0631S
-
|
Isotope-Labeled Compounds
|
Cancer
|
Alendronic acid-d6 is the deuterium labeled Alendronic acid. Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease[1].
|
-
- HY-W004260S1
-
Icosanoic acid-d39
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Arachidic acid-d39 is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].
|
-
- HY-W004260S
-
Icosanoic acid-d2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Arachidic acid-d2 is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].
|
-
- HY-W004284S
-
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
Heptadecanoic acid-d3 is the deuterium labeled Heptadecanoic acid. Heptadecanoic acid is an odd chain saturated fatty acid (OCS-FA). Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis[1].
|
-
- HY-13318S
-
GS 4071-d3; Ro 64-0802-d3; Oseltamivir carboxylate-d3
|
Influenza Virus
|
Infection
|
Oseltamivir acid-d3 is a deuterium labeled Oseltamivir acid. Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses[1][2].
|
-
- HY-116374S
-
-
- HY-135103S
-
|
FXR
|
Cancer
|
Tauro-β-muricholic acid-d4 (sodium) is the deuterium labeled Tauro-β-muricholic acid sodium. Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3].
|
-
- HY-W004260S2
-
Icosanoic acid-d3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Arachidic acid-d3) is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].
|
-
- HY-W004284S1
-
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
Heptadecanoic acid-d33 is the deuterium labeled Heptadecanoic acid. Heptadecanoic acid is an odd chain saturated fatty acid (OCS-FA). Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis[1].
|
-
- HY-W041895S
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
DL-Glutamic acid-d5 is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability[1].
|
-
- HY-W041895S1
-
|
Endogenous Metabolite
|
Others
|
DL-Glutamic acid-d3 is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability[1].
|
-
- HY-W004260S4
-
Icosanoic acid-d4
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
|
Arachidic acid-d4 is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].
|
-
- HY-W000793S
-
-
- HY-13777S
-
Zoledronate-d5; CGP 42446-d5; CGP42446A-d5; ZOL 446-d5
|
Bacterial
Apoptosis
Autophagy
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
Zoledronic acid-d5 is deuterated labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .
|
-
- HY-113121S
-
|
Endogenous Metabolite
|
Cardiovascular Disease
|
Vanillylmandelic acid-d3 is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].
|
-
- HY-12222S
-
INT-747-d5; 6-ECDCA-d5; 6-Ethylchenodeoxycholic acid-d5
|
FXR
Autophagy
|
Others
|
Obeticholic acid-d5 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].
|
-
- HY-15027S
-
-
- HY-12222S1
-
|
FXR
Autophagy
|
Others
|
Obeticholic Acid-d4 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].
|
-
- HY-13936S
-
|
Endogenous Metabolite
|
|
2-(1-Methyl-1H-imidazol-4-yl)acetic acid-d3 is deuterium labeled 2-(1-Methyl-1H-imidazol-4-yl)acetic acid.
|
-
- HY-D0869S
-
|
Isotope-Labeled Compounds
|
Others
|
3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 is the deuterium labeled CAPS[1]. CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis[2][3].
|
-
- HY-Y0084S
-
Eudesmic acid-d3; Trimethylgallic acid-d3
|
Isotope-Labeled Compounds
|
Others
|
3,4,5-Trimethoxybenzoic acid-d3 is the deuterium labeled 3,4,5-Trimethoxybenzoic acid[1]. 3,4,5-Trimethoxybenzoic acid (Eudesmic acid;Trimethylgallic Acid) is a benzoic acid derivative. A building block in medicine and organic synthesis.
|
-
- HY-W009216S3
-
-
- HY-P3143
-
|
PD-1/PD-L1
|
Cancer
|
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs .
|
-
- HY-P3143A
-
|
PD-1/PD-L1
|
Cancer
|
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs .
|
-
- HY-P10341
-
|
GCGR
|
Metabolic Disease
|
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin, which has the ability to continuously improve glycemic control. Meanwhile, ZP3022 can effectively increase the mass of β-cells, promote β-cell proliferation, and enhance the average islet mass. ZP3022 can be used in research for anti-diabetic treatments .
|
-
- HY-14608S7
-
|
Endogenous Metabolite
iGluR
Ferroptosis
Apoptosis
|
Neurological Disease
|
L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
|
-
- HY-14608S8
-
|
Endogenous Metabolite
iGluR
Ferroptosis
Apoptosis
|
Neurological Disease
|
L-Glutamic acid-d3 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
|
-
- HY-A0281S2
-
4-PBA-d5; Benzenebutyric acid-d5
|
HDAC
Virus Protease
|
|
4-Phenylbutyric acid-d5 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[2][3][4].
|
-
- HY-N1902S1
-
|
Keap1-Nrf2
Endogenous Metabolite
|
Metabolic Disease
|
4-Hydroxyphenylacetic acid-d4 is the deuterium labeled 4-Hydroxyphenylacetic acid[1]. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[2].
|
-
- HY-W015240S1
-
|
Endogenous Metabolite
|
Metabolic Disease
|
N-Acetyl-L-glutamic acid-d4 is the deuterium labeled N-Acetyl-L-glutamic acid[1]. N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human[2].
|
-
- HY-W014993S1
-
-
- HY-100806S
-
-
- HY-W011560S
-
-
- HY-B0574S1
-
|
COX
|
Inflammation/Immunology
|
Mefenamic Acid-d3 is the deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
|
-
- HY-B0166S6
-
-
- HY-W010452S
-
β-Hydroxybutyric acid-d2 sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
3-Hydroxybutyric acid-d2 (sodium) is the deuterium labeled 3-Hydroxybutyric acid sodium[1]. 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids[2].
|
-
- HY-17556S1
-
Leucovorin-d4 calcium hydrate
|
Isotope-Labeled Compounds
|
Cancer
|
Folinic acid-d4-1 (Leucovorin-d4-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
|
-
- HY-W008253S1
-
|
Endogenous Metabolite
|
Neurological Disease
Cancer
|
5-Hydroxyindole-3-acetic acid-d6 is the deuterium labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
|
-
- HY-W008253S
-
|
Endogenous Metabolite
|
Neurological Disease
Cancer
|
5-Hydroxyindole-3-acetic acid-d2 is the deuterium labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
|
-
- HY-Y1718S
-
N-Tridecanoic acid-d2
|
Isotope-Labeled Compounds
Endogenous Metabolite
Bacterial
|
|
Tridecanoic acid-d2 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation[1].
|
-
- HY-Y1718S1
-
N-Tridecanoic acid-d25
|
Endogenous Metabolite
Bacterial
|
Cancer
|
Tridecanoic acid-d25 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation[1].
|
-
- HY-Y1718S2
-
N-Tridecanoic acid-d9
|
Isotope-Labeled Compounds
Endogenous Metabolite
Bacterial
|
|
Tridecanoic acid-d9 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation[1].
|
-
- HY-Y0607S
-
|
Isotope-Labeled Compounds
|
Others
|
4-Nitrobenzoic acid-d4 is the deuterium labeled 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate (Vonoprazan Impurity)[1].
|
-
- HY-I0736S
-
|
Drug Metabolite
Endogenous Metabolite
|
Others
|
Isonicotinic acid-d4 is the deuterium labeled Isonicotinic acid[1]. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C[2].
|
-
- HY-W004260S5
-
|
Endogenous Metabolite
|
Others
|
Arachidic acid-d4-1 is the deuterium labeled Arachidic acid[1]. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[2][3].
|
-
- HY-Y1097S
-
2-(Methoxycarbonyl)benzoic acid-d4
|
Isotope-Labeled Compounds
|
Cancer
|
Monomethyl phthalate-d4 (2-(Methoxycarbonyl)benzoic acid-d4) is the deuterium labeled Monomethyl phthalate. Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule .
|
-
- HY-W041195S
-
|
Isotope-Labeled Compounds
|
Others
|
3-Hydroxy-3-methylhexanoic acid-d5 is the deuterium labeled 3-Hydroxy-3-methylhexanoic acid (HY-W041195). 3-Hydroxy-3-methylhexanoic acid is a fatty acid that is one of the metabolic products of leukocytes .
|
-
- HY-W027544S1
-
5-(Dimethyl-d6-amino)-N-(prop-2-ynyl)naphthalene-1-sulfonamide
|
Isotope-Labeled Compounds
|
Others
|
(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-100807S
-
|
Endogenous Metabolite
iGluR
|
Neurological Disease
Inflammation/Immunology
|
Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2].
|
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- HY-113067S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Phytanic acid-d3 is the deuterium labeled Phytanic acid[1]. Phytanic acid is an endogenous metabolite present in Blood that can be used for the research of Zellweger Syndrome, Alpha Methylacyl CoA Racemase Deficiency, Rhizomelic Chondrodysplasia Punctata and Infantile Refsum Disease[2][3][4][5][6].
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-
- HY-W011819S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Tetradecanedioic acid-d24 is the deuterium labeled Tetradecanedioic acid[1]. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions[2].
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-
- HY-W017522S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Adipic acid-d10 is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].
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- HY-W017522S2
-
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Endogenous Metabolite
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Metabolic Disease
|
Adipic acid-d4 is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].
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-
- HY-W017522S4
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Adipic acid-d8 is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].
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-
- HY-N0067S1
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4-Aminobutyric acid-d2
|
Isotope-Labeled Compounds
GABA Receptor
Endogenous Metabolite
|
Neurological Disease
|
γ-Aminobutyric acid-d2 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
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-
- HY-B0574S
-
|
COX
|
Inflammation/Immunology
|
Mefenamic acid-d4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].
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- HY-N0067S
-
4-Aminobutyric acid-d6
|
GABA Receptor
Endogenous Metabolite
|
Neurological Disease
|
γ-Aminobutyric acid-d6 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
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- HY-N0830S18
-
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Isotope-Labeled Compounds
HSP
Endogenous Metabolite
|
|
Palmitic acid-d is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N7057S
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Pelargonic acid-d17
|
Bacterial
|
|
Nonanoic acid-d17 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[1].
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-
- HY-N7057S1
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Pelargonic acid-d3
|
Isotope-Labeled Compounds
Bacterial
|
|
Nonanoic acid-d3 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[1].
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-
- HY-N7057S2
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Pelargonic acid-d4
|
Isotope-Labeled Compounds
Bacterial
|
|
Nonanoic acid-d4 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[1].
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-
- HY-W017522S5
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Adipic acid-d4-1 is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].
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-
- HY-121883S
-
Tetracosanoic acid-d47
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
|
Lignoceric acid-d47 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].
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- HY-N0830S5
-
-
- HY-B1350S
-
Fusidate-d6; SQ-16603-d6
|
Bacterial
Antibiotic
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Infection
|
Fusidic acid-d6 is the deuterium labeled Fusidic acid. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome[1][2].
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- HY-N0830S2
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-
- HY-N0830S4
-
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HSP
|
Cardiovascular Disease
Neurological Disease
Metabolic Disease
Cancer
|
Palmitic acid-d2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S7
-
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HSP
|
Cardiovascular Disease
Neurological Disease
Metabolic Disease
Cancer
|
Palmitic acid-d4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-121883S3
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Endogenous Metabolite
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Neurological Disease
|
Lignoceric acid-d4-11 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].
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- HY-121883S4
-
Tetracosanoic acid-d4-2
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Endogenous Metabolite
|
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Lignoceric acid-d4-2 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].
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- HY-121883SS5
-
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Endogenous Metabolite
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Lignoceric acid-d9 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].
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- HY-N0830S14
-
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Isotope-Labeled Compounds
HSP
Endogenous Metabolite
|
Inflammation/Immunology
|
Palmitic acid-d17 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S20
-
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Isotope-Labeled Compounds
HSP
Endogenous Metabolite
|
|
Palmitic acid-d9 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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-
- HY-N0830S21
-
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Isotope-Labeled Compounds
HSP
Endogenous Metabolite
|
|
Palmitic acid-d5 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-W097197S
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Isotope-Labeled Compounds
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Others
|
(R)-2-((R)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid-d5 is deuterium labeled (R)-2-((R)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid.
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- HY-W168915S
-
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Isotope-Labeled Compounds
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Others
|
1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid-d3 is deuterium labeled 1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid.
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- HY-15027S1
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-
- HY-18569S3
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Indole-3-acetic acid-d7; 3-IAA-d7
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Endogenous Metabolite
Molecular Glues
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Others
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3-Indoleacetic acid-d7 is the deuterium labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.
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- HY-B0398S
-
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Bacterial
Antibiotic
Topoisomerase
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Infection
|
Nalidixic Acid-d5 is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].
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- HY-N0830S11
-
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HSP
|
Cardiovascular Disease
Neurological Disease
Metabolic Disease
Cancer
|
Palmitic acid-d2-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S12
-
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HSP
Endogenous Metabolite
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Cancer
|
Palmitic acid-d4-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2][3].
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- HY-N0830S13
-
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Isotope-Labeled Compounds
HSP
Endogenous Metabolite
|
|
Palmitic acid-d4-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S15
-
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Isotope-Labeled Compounds
HSP
Endogenous Metabolite
|
Cancer
|
Palmitic acid-d2-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S16
-
|
Isotope-Labeled Compounds
HSP
Endogenous Metabolite
|
Cancer
|
Palmitic acid-d2-3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S17
-
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Isotope-Labeled Compounds
HSP
Endogenous Metabolite
|
|
Palmitic acid-d2-4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S19
-
|
Isotope-Labeled Compounds
HSP
Endogenous Metabolite
|
|
Palmitic acid-d2-5 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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-
- HY-W017386S
-
|
Isotope-Labeled Compounds
|
Neurological Disease
|
3-Methyl-2-oxovaleric acid-d8 (sodium) is the deuterium labeled 3-Methyl-2-oxovaleric acid. 3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids[1].
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-
- HY-121883S1
-
Tetracosanoic acid-d3
|
Endogenous Metabolite
|
Neurological Disease
|
Lignoceric acid-d3 is the deuterium labeled Lignoceric acid[1]. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[2][3].
|
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- HY-N7057S3
-
Pelargonic acid-d2; Pelargonic acid-d2 (n-Nonanoic acid, C9 )
|
Bacterial
|
Infection
|
Nonanoic acid-d2 is the deuterium labeled Nonanoic acid[1]. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[2].
|
-
- HY-B1002S
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
|
Oxolinic acid-d5 is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].
|
-
- HY-117275S
-
Meclofenamate-d4
|
Isotope-Labeled Compounds
Gap Junction Protein
Endogenous Metabolite
|
Inflammation/Immunology
|
Meclofenamic acid-d4 is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker[1][2][3].
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-
- HY-W014504S1
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
|
2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid-d7 is the deuterium labeled 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid. 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.
|
-
- HY-N0523S
-
3,4,5-Trihydroxybenzoic acid-d2
|
Apoptosis
COX
Ferroptosis
Endogenous Metabolite
Reactive Oxygen Species
|
|
Gallic acid-d2 is the deuterium labeled Gallic acid[1]. Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)[2]. Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[3].
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-
- HY-W008253S2
-
|
Isotope-Labeled Compounds
|
Others
|
5-Hydroxyindole-3-acetic acid-d5is the deuterium labeled5-Hydroxyindole-3-acetic acid(HY-W008253) . 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors .
|
-
- HY-W718300
-
-
- HY-113371S
-
Methylcitric acid-d3
|
Endogenous Metabolite
|
Metabolic Disease
|
2-Methylcitric acid-d3 is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].
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- HY-N0729S1
-
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
Linoleic acid-d11 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2].
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-
- HY-N0729S
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
Linoleic Acid-d4 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2].
|
-
- HY-16322S
-
YM-529-d4
|
Isotope-Labeled Compounds
P2X Receptor
Apoptosis
|
Cancer
|
Minodronic acid-d4 is deuterium labeled Minodronic acid. Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].
|
-
- HY-W012946S
-
|
Acyltransferase
ATP Citrate Lyase
Endogenous Metabolite
|
Metabolic Disease
|
2-Furoic acid-d3 is the deuterium labeled 2-Furoic acid[1]. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation[2]. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats[3].
|
-
- HY-W012974S
-
|
Endogenous Metabolite
|
|
3-Amino-2-methylpropanoic acid-d3 is the deuterium labeled 3-Amino-2-methylpropanoic acid[1]. 3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors[2].
|
-
- HY-N0729S5
-
Deulinoleic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
Linoleic Acid-d2 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
|
-
- HY-N0729S4
-
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
Metabolic Disease
|
Linoleic Acid-d5 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
|
-
- HY-P4146
-
BI 456906
|
GLP Receptor
GCGR
|
Metabolic Disease
|
Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .
|
-
- HY-P4146A
-
BI 456906 TFA
|
GLP Receptor
GCGR
|
Metabolic Disease
|
Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .
|
-
- HY-113560
-
-
- HY-132334S
-
|
RAR/RXR
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
9-cis-Retinoic acid-d5 is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5][6].
|
-
- HY-B0335S
-
|
COX
|
Inflammation/Immunology
Cancer
|
Tolfenamic acid-d4 is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].
|
-
- HY-14520S
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
Tetrahydrofolic acid-d4 is the deuterium labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1][2].
|
-
- HY-W016099S
-
MQCA-d4
|
Isotope-Labeled Compounds
|
Cancer
|
3-Methyl-2-quinoxalinecarboxylic acid-d4 is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].
|
-
- HY-146767S
-
-
- HY-113097S
-
|
Isotope-Labeled Compounds
|
Others
|
3α,7α-Dihydroxycoprostanic acid-d3is the deuterium labeled3α,7α-Dihydroxycoprostanic acid(HY-113097) . 3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α,7α-Dihydroxycoprostanic acid, a bile acid, is the precursor to chenodeoxycholic acid .
|
-
- HY-15027S3
-
Mesalamine-d3 disodium; 5-ASA-d3 disodium; Mesalazine-d3 disodium
|
PPAR
NF-κB
Endogenous Metabolite
PAK
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
5-Aminosalicylic acid-d3 disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
|
-
- HY-Y1620S
-
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
3-(3,4-Dimethoxyphenyl)propanoic acid-d10 is the deuterium labeled 3-(3,4-Dimethoxyphenyl)propanoic acid. 3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies and other anemias[1].
|
-
- HY-10585AS1
-
Sodium Valproate-d14 sodium
|
Isotope-Labeled Compounds
HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
|
Cancer
|
Valproic acid-d14 (sodium) is deuterium labeled Valproic acid (sodium). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
|
-
- HY-W013636S1
-
Alpha-Ketoglutaric acid-d4
|
Tyrosinase
Endogenous Metabolite
|
Others
|
2-Ketoglutaric acid-d4 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
|
-
- HY-W013636S2
-
|
Tyrosinase
Endogenous Metabolite
|
Others
|
2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
|
-
- HY-N1428S6
-
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
Antibiotic
|
Cancer
|
Citric acid-d4-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.
|
-
- HY-P1162
-
-
- HY-N0492S
-
-
- HY-113038AS1
-
2-Hydroxyglutarate-d4 disodium; 2-Hydroxyglutaric acid-d4 disodium; 2-Hydroxypentanedioic acid-d4 disodium
|
Histone Demethylase
Endogenous Metabolite
|
Cancer
|
α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].
|
-
- HY-113410S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].
|
-
- HY-W027544S
-
7-Methoxy-d3-2-oxo-2H-1-benzopyran-4-acetic acid; 7-Methoxy-d3-2H-chromen-2-one-4-acetic acid
|
Isotope-Labeled Compounds
|
Others
|
(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3].
|
-
- HY-101981S2
-
5'-Uridylic acid-d11 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Uridine 5'-monophosphate-d11 (5'-?Uridylic acid-d11) dilithium is deuterium labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-10585AS
-
Sodium Valproate-d7(sodium)
|
Isotope-Labeled Compounds
HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
|
Cancer
|
Valproic acid-d7 (sodium) is the deuterium labeled Valproic acid (sodium salt). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
|
-
- HY-N0728S2
-
|
PI3K
Akt
|
Cardiovascular Disease
Cancer
|
α-Linolenic acid-d14 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
|
-
- HY-10585S3
-
VPA-d4 sodium; 2-Propylpentanoic acid-d4 sodium
|
Isotope-Labeled Compounds
HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
|
Cancer
|
Valproic acid-d4 (sodium) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
|
-
- HY-118189S
-
|
Isotope-Labeled Compounds
Prostaglandin Receptor
|
Inflammation/Immunology
|
Misoprostol acid-d5 is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers[1]. Misoprostol is an oral agent used to induce labor[2].
|
-
- HY-N0728S
-
|
PI3K
Akt
|
Cardiovascular Disease
Cancer
|
α-Linolenic acid-d5 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
|
-
- HY-Y0682S1
-
EDTA-d16
|
Isotope-Labeled Compounds
|
|
Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
|
-
- HY-B1899S
-
|
Isotope-Labeled Compounds
|
Others
|
Taurodeoxycholic acid-d5is the deuterium labeledTaurodeoxycholic acid(HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) [5].
|
-
- HY-W009162S2
-
5'-Cytidylic acid-d12 dilithium; 5'-CMP-d12 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
Cytidine 5′-monophosphate-d12 (5'-Cytidylic acid-d12 dilithium; 5'-CMP-d12) dilithium is deuterium labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
|
-
- HY-119695AS1
-
-
- HY-10585S4
-
VPA-d4-1; 2-Propylpentanoic acid-d4-1
|
Isotope-Labeled Compounds
HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
|
Cancer
|
Valproic acid-d4-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
|
-
- HY-10585S2
-
VPA-d15; 2-Propylpentanoic acid-d15
|
HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
|
Cancer
|
Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
|
-
- HY-10585S
-
VPA-d4; 2-Propylpentanoic acid-d4
|
HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
|
Cancer
|
Valproic acid-d4 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
|
-
- HY-10585S1
-
VPA-d6; 2-Propylpentanoic acid-d6
|
HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
|
Cancer
|
Valproic acid-d6 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
|
-
- HY-A0143S
-
DGLA-d6; all-cis-8,11,14-Eicosatrienoic acid-d6
|
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
Dihomo-γ-linolenic acid-d6 (DGLA-d6) is the deuterium labeled Dihomo-γ-linolenic acid. Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].
|
-
- HY-119695AS
-
Tenivastatin-d6 ammonium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
|
Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].
|
-
- HY-B0236S1
-
EACA-d10; Epsilon-Amino-n-caproic acid-d10; 6-Aminohexanoic acid-d10
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
6-Aminocaproic acid-d10 is the deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].
|
-
- HY-B0236S
-
EACA-d6; Epsilon-Amino-n-caproic acid-d6; 6-Aminohexanoic acid-d6
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
6-Aminocaproic acid-d6 is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].
|
-
- HY-B1221S
-
|
Isotope-Labeled Compounds
COX
AMPK
Potassium Channel
Chloride Channel
Calcium Channel
Parasite
|
Inflammation/Immunology
|
Flufenamic acid-d4 is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca 2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
|
-
- HY-101329S
-
9-Anthracenecarboxylic acid-d9
|
Chloride Channel
|
Others
|
Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].
|
-
- HY-N5134S3
-
5'-GMP-d12 dilithium; 5'-guanosine monophosphate-d12 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
5'-Guanylic acid-d12 (5'-GMP-d12 dilithium; 5'-guanosine monophosphate-d12) dilithium is deuterium labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
|
-
- HY-P10031
-
|
GLP Receptor
GCGR
|
Metabolic Disease
|
SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors.?SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys .
|
-
- HY-P10031A
-
|
GLP Receptor
|
Metabolic Disease
|
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors.?SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys .
|
-
- HY-14649S2
-
|
RAR/RXR
PPAR
Endogenous Metabolite
Autophagy
|
Cancer
|
11-cis-Retinoic Acid-d5 is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].
|
-
- HY-N2007S
-
3,4-Dimethoxybenzoic acid-d6
|
Isotope-Labeled Compounds
COX
Reactive Oxygen Species
|
Cardiovascular Disease
Inflammation/Immunology
|
Veratric acid-d6 is deuterium labeled Veratric acid. Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
|
-
- HY-N0761AS
-
|
Prostaglandin Receptor
NO Synthase
|
Inflammation/Immunology
|
trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[3].
|
-
- HY-14649S4
-
Vitamin A acid-d5; all-trans-Retinoic acid-d5; ATRA-d5
|
Isotope-Labeled Compounds
RAR/RXR
PPAR
|
Cancer
|
Retinoic acid-d5 is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha [5].
|
-
- HY-P4895
-
|
Oxytocin Receptor
|
Neurological Disease
|
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin (OVT) is an oxytocin receptor antagonist. (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin can be used for the research of neurological disease .
|
-
- HY-P10272
-
PTG-300
|
Ferroportin
|
Others
|
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .
|
-
- HY-14649S3
-
Vitamin A acid-d6; all-trans-Retinoic acid-d6; ATRA-d6
|
RAR/RXR
PPAR
Autophagy
Endogenous Metabolite
|
Cancer
|
Retinoic acid-d6 is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].
|
-
- HY-W285163S
-
Formyl Ciprofloxacin-d8
|
Isotope-Labeled Compounds
|
Others
|
1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
|
-
- HY-W751835
-
Baloxavir-d4
Maximum Cited Publications
21 Publications Verification
Baloxavir acid-d4; S-033447-d4
|
Isotope-Labeled Compounds
|
Others
|
Baloxavir-d4 (Baloxavir acid-d4; S-033447-d4) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d4 (Baloxavir-d4 acid), derived from the proagent Baloxavir-d4 marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d4 inhibits viral RNA transcription and replication and has potently antiviral activity .
|
-
- HY-12765S1
-
|
Isotope-Labeled Compounds
Angiotensin Receptor
|
Cardiovascular Disease
|
Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].
|
-
- HY-N0060BS
-
(E)-Coniferic acid-d3
|
β-catenin
Bcl-2 Family
Ferroptosis
Endogenous Metabolite
|
Cancer
|
(E)-Ferulic acid-d3 is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D1583
-
DBCO-Cy5; Cyanine5 dibenzocyclooctyne
|
Fluorescent Dyes/Probes
|
Cyanine5 DBCO (DBCO-Cy5) is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm) [2].
|
-
- HY-D1327
-
|
Fluorescent Dyes/Probes
|
Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λex=684 nm, λem=710 nm) [1]sup >. Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
Cat. No. |
Product Name |
Type |
-
- HY-157926
-
|
Chelators
|
Nitroso-PSAP is a sensitive and specific chromogenic reagent for iron (Fe 2+), which is used for the colorimetric determination of iron in blood after mineralization with periodic acid. TNitroso-PSAP chelates with iron (Fe 2+) to produce a green complex (λmax=756 nm, Epsilon = 4.5 x 10 < sup > 4 < / sup > dm < sup > 3 < / sup > mol < sup > 1 < / sup > cm < sup > 1 < / sup >) .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1604A
-
|
Sodium Channel
|
Inflammation/Immunology
|
ATX-II TFA is a specific Na + channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na +sup channel in cell cultures. ATX-II TFA sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II TFA also induces pulmonary vein arrhythmogenesis and atrial fibrillation .
|
-
- HY-P4583
-
|
Peptides
|
Others
|
Suc-Val-Pro-Phe-SBzl (succinyl-valine-proline-phenylalanine thiobenzyl ester) is an inhibitor of CatG enzymes with IC50 values of 111-225 mM.
|
-
- HY-P1604
-
|
Sodium Channel
|
Inflammation/Immunology
|
ATX-II is a specific Na + channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na +sup channel in cell cultures. ATX-II sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation .
|
-
- HY-P10324
-
p16<sup>INK4asup> peptide
|
Peptides
|
Cancer
|
TAT-p16 (p16INK4a peptide) is a peptide mimic of p16INK4a that can induce an early G phase cell cycle arrest in the absence of active cyclin E:Cdk2 complex .
|
-
- HY-P0265AS
-
Amyloid Beta-Peptide-<sup>15sup>N (1-40) (human) TFA; Amyloid β-Peptide-<sup>15sup>N (1-40) (human) TFA
|
Amyloid-β
|
Neurological Disease
|
β-Amyloid- 15N (1-40) (TFA) is the 15N-labledβ-Amyloid (1-40) (TFA). β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease[1].
|
-
- HY-W010452S1
-
-
- HY-P5340
-
|
Peptides
|
Others
|
Amyloid-Forming peptide GNNQQNY is a biological active peptide. (This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.)
|
-
- HY-P1363S
-
Amyloid β-peptide-<sup>15sup>N (1-42) (human) TFA
|
Amyloid-β
|
Neurological Disease
|
β-Amyloid- 15N (1-42), human (TFA) is the 15N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease[1].
|
-
- HY-P3350
-
|
Bacterial
|
Infection
|
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].
|
-
- HY-W005541S1
-
B-(3-Ethylphenyl)-Boronic acid-d5
|
Isotope-Labeled Compounds
|
Others
|
3-Ethylphenylboronic acid-d5 (B-(3-Ethylphenyl)-Boronic acid-d5) is a deuterium labeled 3-Ethylphenylboronic acid.
|
-
- HY-P10218A
-
|
PKC
|
Inflammation/Immunology
Cancer
|
MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
|
-
- HY-P10218
-
|
PKC
|
Inflammation/Immunology
Cancer
|
MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
|
-
- HY-P4837
-
|
Peptides
|
Others
|
Ac-Lys-D-Ala-D-lactic acid is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
-
- HY-P10200
-
|
Bacterial
|
Infection
|
CP7-FP13-2 is a peptide with antivirulence factor and antibacterial activity. CP7-FP13-2 inhibits the formation of Staphylococcus aureus biofilm and has good antibacterial efficacy in mice .
|
-
- HY-P0041A
-
-
- HY-P3462
-
|
CGRP Receptor
|
Metabolic Disease
|
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity .
|
-
- HY-P3462A
-
|
CGRP Receptor
|
Metabolic Disease
|
Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies .
|
-
- HY-P5161A
-
|
GCGR
|
Metabolic Disease
|
FC382K10W15 TFA is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 TFA can be used in type 2 diabetes research .
|
-
- HY-P5161
-
-
- HY-105168
-
|
Endothelin Receptor
|
Cardiovascular Disease
|
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .
|
-
- HY-P10271
-
|
GLP Receptor
|
Metabolic Disease
|
RG7697 is a dual agonist for glucagon-like peptide receptor (GLP Receptor) and glucosedependent insulinotropic polypeptide receptor (GIPR), with EC50 of 5 and 3 pM, respectively. RG7697 exhibits antihyperglycemic property .
|
-
- HY-P3143
-
|
PD-1/PD-L1
|
Cancer
|
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs .
|
-
- HY-P3143A
-
|
PD-1/PD-L1
|
Cancer
|
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs .
|
-
- HY-P10341
-
|
GCGR
|
Metabolic Disease
|
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin, which has the ability to continuously improve glycemic control. Meanwhile, ZP3022 can effectively increase the mass of β-cells, promote β-cell proliferation, and enhance the average islet mass. ZP3022 can be used in research for anti-diabetic treatments .
|
-
- HY-P4146
-
BI 456906
|
GLP Receptor
GCGR
|
Metabolic Disease
|
Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .
|
-
- HY-P4146A
-
BI 456906 TFA
|
GLP Receptor
GCGR
|
Metabolic Disease
|
Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .
|
-
- HY-113560
-
-
- HY-P1162
-
-
- HY-P10031
-
|
GLP Receptor
GCGR
|
Metabolic Disease
|
SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors.?SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys .
|
-
- HY-P10031A
-
|
GLP Receptor
|
Metabolic Disease
|
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors.?SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys .
|
-
- HY-P4895
-
|
Oxytocin Receptor
|
Neurological Disease
|
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin (OVT) is an oxytocin receptor antagonist. (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin can be used for the research of neurological disease .
|
-
- HY-P10272
-
PTG-300
|
Ferroportin
|
Others
|
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .
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* This product has been "discontinued".
Optimized version of product available:
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Cat. No. |
Product Name |
Chemical Structure |
-
- HY-143368S
-
|
L-Phenylmercapturic acid-d5is the deuterium labeledL-Phenylmercapturic acid(HY-143368) . L-Phenylmercapturic acid is often used as a biomarker for exposure to aniline compounds such as aniline and xylene .
|
-
-
- HY-15306S
-
1 Publications Verification
|
Eltrombopag- 13C4 (SB-497115- 13C4) is 13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells [5].
|
-
-
- HY-N0733S2
-
|
Glucosamine- 13C, 15N (hydrochloride) is the 13C and 15N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, i
|
-
-
- HY-B0271S1
-
|
Pyrazinamide- 13C, 15N is 15N and 13C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
|
-
-
- HY-N0650S6
-
|
L-Serine1- 13C, 15N is the 13C- and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
-
- HY-A0061S
-
|
Trifluridine- 13C, 15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].
|
-
-
- HY-Y0418S
-
|
Dulcite- 13C is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
|
-
-
- HY-13458S1
-
|
Droxidopa- 13C2, 15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier[1][2].
|
-
-
- HY-66005S4
-
|
Acetaminophen- 13C2, 15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].
|
-
-
- HY-15236S1
-
|
PSI-6206-d1, 13C, 15N2 is 15N and 13C labeled PSI-6206 (HY-15236). PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
|
-
-
- HY-13613S2
-
|
Dutasteride- 13C, 15N,d is 15N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
|
-
-
- HY-B0389S10
-
|
D-Glucose- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
-
- HY-B0389S29
-
|
D-Glucose- 18O is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules
|
-
-
- HY-Y1250S6
-
|
Fmoc-Gly-OH- 13C2, 15N is a 15N-labeled and 13C-labled Crystal Violet. Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.
|
-
-
- HY-N1480S
-
|
(-)-Fucose- 13C is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[1]
|
-
-
- HY-125818S2
-
|
Cytidine-5'-triphosphate- 13C,d1 (Cytidine triphosphate- 13C,d1 dilithium; 5'-CTP- 13C,d1) dilithium is deuterium and 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
|
-
-
- HY-W067028S
-
|
Semicarbazide- 13C, 15N2 hydrochloride is 15N and 13C labeled Semicarbazide.
|
-
-
- HY-Z0283S
-
|
Benzamide- 15N is a 15N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP)[1][2].
|
-
-
- HY-A0070AS1
-
|
Liothyronine- 13C9, 15N is the 13C and 15N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].
|
-
-
- HY-B0215S1
-
|
Acetylcysteine- 15N (N-Acetylcysteine- 15N) is the 15N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].
|
-
-
- HY-Y0504S2
-
|
Trimethylammonium chloride- 15N is the 15N labeled Trimethylammonium chloride[1]. Trimethylammonium chloride is an endogenous metabolite.
|
-
-
- HY-B0150S1
-
|
Nicotinamide- 15N, 13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
|
-
-
- HY-N0733S5
-
|
Glucosamine- 13C6, 15N (hydrochloride) is the 13C and 15N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids,
|
-
-
- HY-13417S
-
|
AICAR- 13C2, 15N (Acadesine- 13C2, 15N; AICA Riboside- 13C2, 15N)is the 13C and 15N labeledAICAR(HY-13417) . AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .
|
-
-
- HY-B0178AS
-
|
Guanidine- 13C, 15N3 (hydrochloride)is the 13C-labeled and 15N-labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2].
|
-
-
- HY-N0650S5
-
|
L-Serine- 13C3, 15N is the 13C- and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
-
- HY-13677S1
-
|
6-Mercaptopurine- 13C2, 15N is the 13C- and 15N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
|
-
-
- HY-N0091S1
-
|
Hypoxanthine- 13C, 15N2 is a 15N-labeled and 13C-labled Furaltadone. Furaltadone, a nitrofuran agent, has the potential for the study in infections of chickens with salmonella enteritidis. Furaltadone is inhibitory and bactericidal in vitro for staphylococci
|
-
-
- HY-N0091S3
-
|
Hypoxanthine- 13C2, 15N is a 15N-labeled and 13C-labled DL-Cystine[1].
|
-
-
- HY-13623S1
-
|
Entecavir- 13C2, 15N (BMS200475- 13C2, 15N; SQ34676- 13C2, 15N) is a 13C- and 15N-labeled Entecavir (HY-13623). Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
|
-
-
- HY-14164S1
-
|
Zileuton- 13C2, 15N is 15N and 13C labeled Zileuton (HY-14164). Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
|
-
-
- HY-N0667S4
-
|
L-Asparagine-4- 13C (monohydrate) is the 13C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
|
-
-
- HY-Y0418S1
-
|
Dulcite- 13C-1 is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
|
-
-
- HY-Y0418S2
-
|
Dulcite- 13C-2 is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
|
-
-
- HY-Y0418S3
-
|
Dulcite- 13C-3 is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
|
-
-
- HY-B0617S1
-
|
S-Adenosyl-L-methionine- 13C is the 13C labeled S-Adenosyl-L-methionine[1]. S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research[2][3][4].
|
-
-
- HY-Y0842S
-
|
Formamide- 13C is the 13C-labeled Formamide. Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.
|
-
-
- HY-101037S
-
|
Sarcosine- 15N is the 15N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
|
-
-
- HY-N0623S1
-
|
L-Tryptophan- 13C is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
|
-
-
- HY-N0623S7
-
|
L-Tryptophan- 15N is the 15N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
|
-
-
- HY-N0378S1
-
|
D-Mannitol- 13C is the 13C labeled D-Mannitol[1][2][3][4].
|
-
-
- HY-N0733S
-
|
Glucosamine- 13C (hydrochloride) is the 13C labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a
|
-
-
- HY-N1150S2
-
|
Thymidine- 13C is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]
|
-
-
- HY-N0733S4
-
|
Glucosamine- 15N (hydrochloride) is the 15N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a
|
-
-
- HY-N0545S
-
|
Taurocholic acid- 13C2, 15N (sodium) is the 13C- and 15N- labeled Taurocholic acid (sodium).
|
-
-
- HY-14291S2
-
|
Vildagliptin- 13C5, 15N (LAF237- 13C5, 15N; NVP-LAF 237- 13C5, 15N) is a 13C- and 15N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
|
-
-
- HY-B0389S11
-
|
D-Glucose- 13C-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
-
- HY-B0389S12
-
|
D-Glucose- 13C-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
-
- HY-B0389S16
-
|
D-Glucose- 13C-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
-
- HY-B0389S17
-
|
D-Glucose- 13C-5 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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-
- HY-B0389S13
-
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D-Glucose- 13C-3 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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-
- HY-W338294S
-
|
2'-Deoxycytidine- 13C (monohydrate) is the 13C labeled 2'-Deoxycytidine[1].
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-
- HY-B0389S30
-
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D-Glucose- 18O-1 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
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-
- HY-B0389S31
-
|
D-Glucose- 18O-2 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
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-
- HY-B0389S32
-
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D-Glucose- 18O-3 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
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-
- HY-B0389S19
-
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D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sign
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-
- HY-N0537S2
-
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Xylose-1- 13C is the 13C labeled Xylose.
|
-
- HY-N0537S3
-
|
Xylose-2- 13C is the 13C labeled Xylose.
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-
- HY-N0537S4
-
|
Xylose-5- 13C is the 13C labeled Xylose.
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-
- HY-N0537S5
-
|
Xylose-3- 13C is the 13C labeled Xylose.
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-
- HY-N0537S6
-
|
Xylose-4- 13C is the 13C labeled Xylose.
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-
- HY-N0537S
-
|
Xylose- 18O is the 18O labeled Xylose.
|
-
- HY-16637S4
-
|
Folic acid- 15N, 13C5 is the 13C5 and 15N labeled Folic acid (HY-16637) .
|
-
- HY-N0157S1
-
|
Orotic acid- 13C, 15N2 (monohydrate) is the 13C and 15N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].
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-
- HY-N0650S1
-
|
L-Serine- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-N0650S10
-
|
L-Serine- 15N is the 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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-
- HY-B0228S5
-
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Adenosine- 13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology,
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-
- HY-D0844S
-
1 Publications Verification
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Glutathione oxidized- 13C4, 15N2 is the 13C and 15N labeled Glutathione oxidized (HY-D0844). Glutathione oxidized is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes[1][2].
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-
- HY-D0184S3
-
|
2'-Deoxycytidine- 13C9, 15N3 (Deoxycytidine- 13C9, 15N3; Cytosine deoxyriboside- 13C9, 15N3; Deoxyribose cytidine- 13C9, 15N3) is 13C and 15N-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
|
-
- HY-106950CS
-
|
Fosfructose-1- 13C (sodium) is the 13C labeled Fosfructose[1].
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-
- HY-106950CS1
-
|
Fosfructose-2- 13C (sodium) is the 13C labeled Fosfructose[1].
|
-
- HY-106950CS3
-
|
Fosfructose-6- 13C (sodium) is the 13C labeled Fosfructose[1].
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-
- HY-N1480S1
-
|
(-)-Fucose- 13C-1 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
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-
- HY-N1480S2
-
|
(-)-Fucose- 13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
|
-
- HY-N1480S3
-
|
(-)-Fucose- 13C-3 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
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-
- HY-N0230S
-
|
β-Alanine- 13C3, 15N is the 13C- and 15N-labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
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-
- HY-N0091S4
-
|
Hypoxanthine- 13C2, 15N-1 is a 15N-labeled and 13C-labled 4-Hydroxyestrone[1].
|
-
- HY-15129S
-
|
O-Phospho-L-serine- 13C3, 15N is the 13C- and 15N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2[1].
|
-
- HY-138253S
-
|
2′,2′-Difluorodeoxyuridine- 13C, 15N2 (dFdU- 13C, 15N2; 2',2'-Difluoro-2'-deoxyuridine- 13C, 15N2) is a 13C- and 15N-labeled compound.
|
-
- HY-N0593S3
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|
Deoxycholic acid- 13C is the 13C-labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
|
-
- HY-100582S
-
|
Ribitol-1- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-100582S1
-
|
Ribitol-2- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-100582S2
-
|
Ribitol-3- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-100582S3
-
|
Ribitol-5- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-I0400S
-
|
N-Acetylneuraminic acid- 13C is the 13C labeled N-Acetylneuraminic acid.
|
-
- HY-163080S
-
|
Selenium-77 (77Se) is a stable (non-radioactive) isotope of Selenium. Selenium-77 is both naturally occurring and produced by fission.
|
-
- HY-B0139S
-
|
Flucytosine- 13C, 15N2 (NSC 103805- 13C, 15N2; Ro 2-9915- 13C, 15N2) is a 13C- and 15N-labeled Flucytosine (HY-B0139).
|
-
- HY-16637S2
-
|
(Rac)-Folic acid- 13C5, 15N is the 13C-labeled and 15N-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
|
-
- HY-N1150S8
-
|
Thymidine- 13C10, 15N2 is the 13C and 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
|
-
- HY-B1092AS
-
|
Gluconate-1- 13C (sodium) is the 13C labeled Gluconate sodi[1][2].
|
-
- HY-N0623S4
-
|
L-Tryptophan- 13C11, 15N2 is the 13C- and 15N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
|
-
- HY-D0187S
-
|
L-Glutathione reduced- 13C2, 15N is the 13C- and 15N-labeled L-Glutathione reduced. L-Glutathione reduced (GSH) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
|
-
- HY-N0097S6
-
|
Guanosine- 13C10, 15N5 is the 13C and 15N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .
|
-
- HY-N0623S3
-
|
L-Tryptophan-1- 13C is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
|
-
- HY-B0166S1
-
|
L-Ascorbic acid- 13C is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
|
-
- HY-W338294S2
-
|
2'-Deoxyguanosine- 13C (monohydrate) Monohydrate is the 13C labeled 2'-Deoxyguanosine[1].
|
-
- HY-N2353S
-
|
Arabinose-1- 13C is the 13C labeled Arabinose. Arabinose is an endogenous metabolite[1].
|
-
- HY-N0378S3
-
|
D-Mannitol-2- 13C is the 13C labeled D-Mannitol.
|
-
- HY-N0733S1
-
|
Glucosamine-2- 13C (hydrochloride) is the 13C labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as
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-
- HY-N0733S3
-
|
Glucosamine-6- 13C (hydrochloride) is the 13C labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as
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-
- HY-128850S1
-
|
N-Acetyl-D-mannosamine- 13C is the 13C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1][2]
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-
- HY-N1150S4
-
|
Thymidine- 13C-2 is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]
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-
- HY-N1150S3
-
|
Thymidine- 13C-1 is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]
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-
- HY-128850S5
-
|
N-Acetyl-D-mannosamine- 15N is the 15N labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1][2]
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-
- HY-108213S
-
|
Inosinic acid- 13C10, 15N4 dilithium (5'-IMP-13C10,15N4 (dilithium); IMP-13C10,15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-13C10,15N4 (dilithium)) is 13C- and 15N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .
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-
- HY-N0305S
-
|
5-Aminolevulinic acid- 15N (hydrochloride) is the 15N-labeled 5-Aminolevulinic acid (hydrochloride). 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
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-
- HY-W000450S
-
|
5-Aminolevulinic acid- 13C is the 13C-labeled 5-Aminolevulinic acid. 5-Aminolevulinic acid (5-ALA) is a non-protein amino acid that plays a rate-limiting role in heme biosynthesis.
|
-
- HY-W338294S1
-
|
2'-Deoxycytidine- 13C-2 (monohydrate) Monohydrate is the 13C labeled 2'-Deoxycytidine[1].
|
-
- HY-N0305S2
-
|
5-Aminolevulinic acid- 13C (hydrochloride) is the 13C labeled 5-Aminolevulinic acid hydrochloride[1]. 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles[2][3].
|
-
- HY-N0091S
-
|
Hypoxanthine- 13C5, 15N4 is a 15N-labeled and 13C-labled Dansyl chloride.
|
-
- HY-B1118S1
-
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Secnidazole- 13C2, 15N2 is the 13C2, 15N2 labeled Secnidazole. Secnidazole (RP-14539;PM-185184) is an orally active azole antibiotic with a longer half-life than metronidazole (HY-B0318). Secnidazole is against the vaginosis-associated bacteria and has the potential for bacterial vaginosis research.
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-
- HY-17563S1
-
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2'-Deoxyguanosine- 13C10, 15N5 (Deoxyguanosine- 13C10, 15N5; Guanine deoxyriboside- 13C10, 15N5) is a 13C- and 15N-labeled 2'-Deoxyguanosine (HY-17563).
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-
- HY-B0456S
-
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Riboflavin- 13C4, 15N2is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
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-
- HY-Y0219S
-
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NSC 83128- 13C2, 15N3 is the 13C and 15N labeled NSC 83128[1].
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-
- HY-107372S
-
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Uridine triphosphate- 13C9, 15N2 (sodium) is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis.
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-
- HY-W011240S1
-
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Hydroflumethiazide- 15N2, 13C,d2 is the 13C- and 15N-labeled Hydroflumethiazide[1].
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-
- HY-B0152S2
-
|
Adenine- 13C5,15C5 (6-Aminopurine- 13C5,15C5; Vitamin B4- 13C5,15C5) is 13C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
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-
- HY-118560S
-
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Tricyclodecenyl acetate- 13C2 is 13C labeled 2-Acetylthiazole.
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-
- HY-A0161S
-
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Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2][3].
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-
- HY-N0667S2
-
|
L-Asparagine- 15N2 (monohydrate) is the 15N-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
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-
- HY-N0667S3
-
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L-Asparagine- 13C4 (monohydrate) is the 13C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
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-
- HY-N0898S
-
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Catechin- 13C3 is the 13C-labeled Catechin. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
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-
- HY-13966S2
-
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2-Deoxy-D-glucose- 13C is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].
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-
- HY-W015824S1
-
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DL-Aspartic acid- 13C, 15N is the 13C, and 15N-labeled DL-Aspartic acid.
|
-
- HY-N0230S1
-
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β-Alanine- 15N is the 15N-labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
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-
- HY-N0650S2
-
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L-Serine-1- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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-
- HY-N0650S4
-
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L-Serine-2- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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-
- HY-B0400S2
-
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D-Sorbitol- 13C-1 is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
|
-
- HY-B0400S3
-
|
D-Sorbitol- 13C-2 is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
|
-
- HY-B0400S15
-
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D-Sorbitol- 18O-1 is the 18O labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
|
-
- HY-B0228S4
-
|
Adenosine-1′- 13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo
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-
- HY-B0228S2
-
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Adenosine-2′- 13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo
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-
- HY-B0228S3
-
|
Adenosine-3′- 13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo
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-
- HY-B0226S
-
|
Nitrofurazone- 13C, 15N2 (Nitrofural- 13C, 15N2) is the 13C and 15N labled Nitrofurazone (HY-B0226) . Nitrofurazone is a potential antibiotic that can be used topically to treat wounds, burns, ulcers and skin infections to combat various microorganisms and to prepare surfactants . Nitrofurazone may affect the ecosystem function in Marine environment and affect the functional processes of epiphytic fauna .
|
-
- HY-10572S1
-
|
Efavirenz- 13C6 is the 13C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1].
|
-
- HY-B0389A
-
3 Publications Verification
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D-Glucose- 13C6 is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose- 13C6 can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard .
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-
- HY-B0389S14
-
|
D-Glucose- 13C2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-B0375S1
-
|
Argatroban- 13C6 hydrochloride is 13C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.
|
-
- HY-N0650S3
-
|
L-Serine- 13C3, 15N,d3 is the deuterium, 13C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-B0141S4
-
|
Estradiol- 13C6 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
|
-
- HY-B0141S5
-
|
Estradiol- 13C2 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
|
-
- HY-16973S
-
|
Fluralaner- 13C2, 15N,d3 is the deuterium, 13C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
|
-
- HY-150712S
-
|
Uridine triphosphate- 13C9, 15N5 dilithium is the 13C and 15N labeled Uridine triphosphate dilithium .
|
-
- HY-N0717S1
-
|
L-Valine- 13C5, 15N is the 13C- and 15N-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
- HY-B0503S
-
|
2-Thiouracil- 13C, 15N2 is the 13C, 15N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.
|
-
- HY-I0400S1
-
|
N-Acetylneuraminic acid- 13C-1 is the 13C labeled N-Acetylneuraminic acid.
|
-
- HY-I0400S2
-
|
N-Acetylneuraminic acid- 13C-2 is the 13C labeled N-Acetylneuraminic acid.
|
-
- HY-I0400S3
-
|
N-Acetylneuraminic acid- 13C-3 is the 13C labeled N-Acetylneuraminic acid.
|
-
- HY-B0003S
-
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Gemcitabine- 13C, 15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride[1]. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2][3].
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- HY-B0211S
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Riluzole- 13C, 15N2 is the 13C and 15N labeled Riluzole[1]. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].
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- HY-W015824S5
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DL-Aspartic acid- 13C, 15N-1 hydrochloride is the 13C and 15N labeled DL-Aspartic acid.
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-
- HY-W010918S
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Adenosine 5'-diphosphate-d13 (Adenosine diphosphate-d13 dilithium; ADP-d13) dilithium is deuterium labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
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- HY-B0149S3
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Tranexamic acid- 13C2, 15N (Cyclocapron- 13C2, 15N) is the 13C2 and 15N labeled Tranexamic acid. Tranexamic acid is an antifibrinolytic agent that alleviates liver damage and fibrosis in mouse models of chronic bile duct injury .
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- HY-A0003S2
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Lenalidomide- 13C5, 15N is 15N and 13C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .
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-
- HY-10984S3
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Pomalidomide- 15N, 13C5 is 15N and 13C labeled Pomalidomide (HY-10984). Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
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-
- HY-13948BS
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Angiotensin II human- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
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- HY-50896S1
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Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].
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-
- HY-12008S1
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Erlotinib- 13C6 (hydrochloride) is the 13C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2]. Erlotinib-13C6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-15027S2
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5-Aminosalicylic acid- 13C6 is the 13C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].
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- HY-D0184S2
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2'-Deoxycytidine- 15N3 is the 15N labeled 2'-Deoxycytidine[1]. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu)[2].
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- HY-D0184S5
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2'-Deoxycytidine- 13C9 (Deoxycytidine- 13C9; Cytosine deoxyriboside- 13C9; Deoxyribose cytidine- 13C9) is 13C-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
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- HY-143704S
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5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
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-
- HY-B0456S1
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Riboflavin-5-Phosphate- 13C4, 15N2-1 is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
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- HY-B0158S5
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Cytidine- 13C9, 15N3 is the 13C and 15N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].
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-
- HY-N5134S5
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5'-Guanylic acid- 13C10, 15N5 (5'-GMP- 13C10, 15N5 dilithium; 5'-guanosine monophosphate- 13C10, 15N5) dilithium is 13C and 15N-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
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-
- HY-W009162S5
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Cytidine 5′-monophosphate- 13C9, 15N3 (5'-Cytidylic acid- 13C9, 15N3 dilithium; 5'-CMP- 13C9, 15N3) dilithium is 13C and 15N-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
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- HY-101400S2
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Deoxycytidine triphosphate- 13C9, 15N3 (dCTP- 13C9, 15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate- 13C9, 15N3) dilithium is 13C and 15N-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
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- HY-17413S1
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Zidovudine- 13C,d3 is the 13C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-106950S1
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Fosfructose- 13C6 (tetrasodium hydrate) is the 13C labeled Fosfructose (HY-106950). Fosfructose is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma[1].
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- HY-B1431S1
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Butylparaben- 13C6 is the 13C labeled Butylparaben[1]. Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.
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- HY-N0305S3
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5-Aminolevulinic acid- 13C-1 (5-ALA- 13C-1) hydrochloride is the 13C labeled 5-Aminolevulinic acid hydrochloride . 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles .
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-
- HY-B0139AS
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Flucytosine- 15N3 hydrochloride is 15N labeled Flucytosine.
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-
- HY-B1290S3
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2-Phenylethanol- 13C2 is 13C labeled β-Caryophyllene (HY-B1290). β-Caryophyllene is a CB2 receptor agonist.
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- HY-N0229S
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L-Alanine-2- 13C, 15Nis the 13C-labeled and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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-
- HY-Y0271S
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Urea- 15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
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-
- HY-N1446S
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Oleic acid- 13C is the 13C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].
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-
- HY-N0229S11
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L-Alanine-1- 13C, 15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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- HY-B0351S2
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Taurine- 13C2, 15N is the 13C- and 15N- labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes[1][2][3].
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- HY-B0035S2
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Sulfamethazine- 13C6 is a 13C-labeled n-Acetyl-s-methyl-l-cysteine[1].
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-
- HY-A0253S
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Cefacetrile- 13C3 is the 13C3 labeled Cefacetrile.
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-
- HY-B0166S2
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L-Ascorbic acid- 13C-1 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen
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- HY-B0166S3
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L-Ascorbic acid- 13C-2 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen
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- HY-B0166S4
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L-Ascorbic acid- 13C-3 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen
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- HY-B0166S5
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L-Ascorbic acid- 13C-4 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collag
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- HY-128850S2
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N-Acetyl-D-mannosamine- 13C-1 is the 13C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1][2]
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- HY-90006S1
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5-Fluorouracil- 13C, 15N2 is the 13C and 15N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].
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- HY-N1150S9
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Thymidine- 15N2 is the 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
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-
- HY-W018603S
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Trifluorothymine- 13C, 15N2 is the 13C and 15N labeled Trifluorothymine[1].
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-
- HY-B1449S9
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Uridine- 13C, 15N2 (β-Uridine- 13C, 15N2) is a 13C- and 15N-labeled Uridine (HY-B1449).
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- HY-111095S1
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D-(-)-Lactic acid-13C ((R)-2-Hydroxypropionic acid-13C) is a 13C-labeled D-Lactic acid. D-(-)-Lactic acid-13C can be used as an internal standard and can also be used in studies such as metabolic tracing.
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-
- HY-77956S
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Thyminose- 13C is the 13C labeled Thyminose. Thyminose is an endogenous metabolite[1].
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- HY-N2840S
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Allitol- 13C is the 13C labeled Allitol. Allitol is a rare natural polyol that can be used as a sweetener. Allitol is an important intermediate for the preparation of the agents which against diabetes, cancer, and viral infections, including AIDS[1]
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- HY-B1659S1
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Glycerol- 13C is the 13C labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[1][2][3][4].
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- HY-Y0721S
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3-Bromofluorobenzene- 13C6 is the 13C labeled 3-Bromofluorobenzene[1].
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-
- HY-13966S4
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2-Deoxy-D-glucose- 13C-1 is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].
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- HY-N0055S
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Chlorogenic acid- 13C3 (Heriguard- 13C3; NSC-407296- 13C3) is 13C- and 15N-labeled Chlorogenic acid (HY-N0055). Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension .
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-
- HY-B0234S
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Estrone- 13C3 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
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- HY-40354S
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Tofacitinib- 13C3 is the 13C-labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
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- HY-N0623S2
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L-Tryptophan- 13C11 is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
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- HY-N0623S8
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L-Tryptophan- 15N2 is the 15N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
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- HY-B0150S2
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Nicotinamide- 13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
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- HY-B0234S3
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Estrone- 13C2 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
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- HY-B0213S1
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Sulfameter- 13C6 is the 13C6 labeled Sulfameter. Sulfameter (Sulfametoxydiazine; 5-Methoxysulfadiazine) is an effective long-acting sulfonamide antibiotic with antibacterial activities. Sulfameter can be used for the research of urinary tract infections and lepriasis.
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- HY-B1331S1
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Cyromazine- 13C3 is the 13C3 labeled Cyromazine. Cyromazine is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects.
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- HY-B0158S1
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Cytidine- 13C is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine
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- HY-N0097S3
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Guanosine- 15N5 is the 15N labeled Guanosine[1]. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity[2].
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- HY-N0378S2
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D-Mannitol- 13C6 is the 13C labeled D-Mannitol[1]. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator[2][3][4].
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- HY-D0187S4
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L-Glutathione reduced- 13C (GSH- 13C; γ-L-Glutamyl-L-cysteinyl-glycine- 13C) is 13C-labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced is an endogenous antioxidant and oxygen free radical scavenger.
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- HY-D0187S6
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L-Glutathione reduced- 15N (GSH- 15N; γ-L-Glutamyl-L-cysteinyl-glycine- 15N) is 15N-labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant that scavenges oxygen free radicals.
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- HY-N1150S11
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Thymidine- 13C10 (DThyd- 13C10; NSC 21548- 13C10) is 13C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
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- HY-100196S1
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Pyrroloquinoline quinone-13C3 (sodium) is an isotope of Pyrroloquinoline quinone. Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .
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- HY-N0097S4
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Guanosine- 13C10 is the 13C labeled Guanosine (HY-N0097). Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .
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-
- HY-Y0589S
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m-Cyanobenzoic acid- 13C6 is the 13C labeled m-Cyanobenzoic acid[1].
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-
- HY-13756S
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Tacrolimus- 13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].
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- HY-B0389S18
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D-Glucose- 13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-B0389S15
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D-Glucose- 13C2-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-B0389S9
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D-Glucose- 13C3-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-14855S
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Tedizolid- 13C,d3 is the 13C- and deuterium labeled Tedizolid. Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome.
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- HY-B0457S2
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Clomipramine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
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- HY-B0389S21
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D-Glucose- 13C,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
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- HY-B0389S25
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D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
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-
- HY-Y1298S
-
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Methyl acetylacetate- 13C4 is an isotopically labeled compound. Methyl acetylacetate- 13C4 can be used for various biochemical studies[1].
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- HY-N1393S
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2-Methoxybenzoic acid- 13C6 is the 13C-labeled 2-Methoxybenzoic acid. 2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.
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- HY-A0042S1
-
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Rufinamide- 15N,d2 is the deuterium and 15N labeled Rufinamide[1]. Rufinamide is a new antiepileptic agent that differs structurally from other antiepileptic agents and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS)[2][3].
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- HY-N0098S2
-
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Vanillin- 13C6 is the 13C labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
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-
- HY-B1511S
-
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Cyclic AMP- 13C5 is a deuterated cyclic AMP.
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-
- HY-16561S1
-
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Resveratrol- 13C6 is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].
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-
- HY-113294S
-
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3-Hydroxykynurenine- 13C3, 15N (3-Hydroxy-DL-kynurenine- 13C3, 15N)is the 13C and 15N labeled3-Hydroxykynurenine(HY-113294) . 3-Hydroxykynurenine, a?metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis .
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-
- HY-18341S1
-
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Thyroxine hydrochloride- 13C6 is the 13C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].
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-
- HY-N0650S
-
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L-Serine- 13C3 is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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-
- HY-N0229S10
-
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L-Alanine- 13C3, 15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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- HY-N0682S3
-
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Pyridoxine- 13C4 (hydrochloride) is the 13C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
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- HY-N0229S15
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L-Alanine- 13C2, 15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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- HY-N0091S2
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Hypoxanthine- 13C5 is a 13C-labeled H-Lys-OH.2HCl[1].
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-
- HY-N0684S3
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Vitamin K1- 13C6 is the 13C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
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- HY-B0495S4
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Lamotrigine- 13C3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
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- HY-15398S4
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Vitamin D3- 13C5 is the deuterium labeled Vitamin D3 (HY-15398). Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells[1][2].
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- HY-13613S
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Dutasteride- 13C6 is the 13C labeled Dutasteride[1]. Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT[2].
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- HY-19821S1
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Fmoc-Ile-OH- 13C6, 15N is the 13C and 15N labeled Fmoc-Ile-OH[1]. Fmoc-Ile-OH is an isoleucine derivative[2].
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- HY-B0228S1
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Adenosine- 13C5 is the 13C labeled Adenosine[1]. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[2][3].
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- HY-B0400S16
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D-Sorbitol- 13C6 is the 13C labeled D-Sorbitol[1]. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[2].
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- HY-N0091S7
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1 Publications Verification
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Hypoxanthine- 15N4 is the 15N labeled Hypoxanthine[1]. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia[2].
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- HY-B0228S11
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Adenosine- 15N5 (Adenine riboside- 15N5; D-Adenosine- 15N5) is the 15N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .
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- HY-N7745S2
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Glucosylsphingosine- 13C6 is an active compound. Glucosylsphingosine- 13C6 can be used for various studies .
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- HY-17563S2
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2'-Deoxyguanosine- 13C10 (Deoxyguanosine- 13C10; Guanine deoxyriboside- 13C10) is 13C-labeled 2'-Deoxyguanosine (HY-17563). 2'-Deoxyguanosine (Deoxyguanosine) is deoxyguanosine.
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- HY-17563S4
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2'-Deoxyguanosine- 15N5 (Deoxyguanosine- 15N5; Guanine deoxyriboside- 15N5) is 15N labeled 2'-Deoxyguanosine (HY-17563). 2'-Deoxyguanosine (Deoxyguanosine) is deoxyguanosine.
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- HY-B0228S13
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Adenosine- 13C10 (Adenine riboside- 13C10; D-Adenosine- 13C10) is 13C-labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
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- HY-B1028S
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Pantethine- 15N2 is the 15N2 labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration [5] .
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- HY-A0084S1
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Procainamide- 13C2 hydrochloride is 13C labeled Procainamide. Procainamide hydrochloride is an antiarrhythmic agent used in the study of cardiac arrhythmias.
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- HY-B0504S1
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Creatinine- 13C is the 13C-labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.
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- HY-76847S2
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Chenodeoxycholic acid- 13C is the 13C-labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
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- HY-N1420AS
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Rhamnose- 13C (monohydrate) is the 13C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate c
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- HY-B2227BS2
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Lactate- 13C (sodium) is the 13C labeled Lactate sodium[1]. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium functions in a variety of biochemical processes[2].
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- HY-W096993S1
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TPABr (Tetrapropylammonium bromide)- 15N is the 15N labeled TPABr (Tetrapropylammonium bromide) .
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- HY-133968S1
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24-Methylenecholesterol- 13C (Ostreasterol- 13C)is the 13C labeled24-Methylenecholesterol(HY-133968) . 24-Methylenecholesterol (Ostreasterol), a natural marine sterol, stimulates cholesterol acyltransferase in human macrophages. 24-Methylenecholesterol possess anti-aging effects in yeast. 24-methylenecholesterol enhances honey bee longevity and improves nurse bee physiology .
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- HY-B0892S5
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Benzyl alcohol- 13C is the 13C labeled Benzyl alcohol (HY-B0892). Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor .
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- HY-126050S
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(R)-Pantetheine- 15N (Pantetheine- 15N) is the 15N labeled (R)-Pantetheine (HY-126050). (R)-Pantetheine is the biosynthetic precursor to CoA .
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- HY-W768338
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Sucrose- 13C is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .
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- HY-B0445S1
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NAD+- 13C5-1 is the 13C labeled NAD+[1]. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
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- HY-141939S
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Triiodothyronine- 13C6 (hydrochloride) is the 13C labeled Triiodothyronine[1].
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- HY-B0456S2
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Riboflavin- 13C5 is the 13C-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
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- HY-W011240S
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Hydroflumethiazide- 13C,d2 is the deuterium and 13C labeled Hydroflumethiazide[1].
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- HY-W013812S
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Ethyl linoleate- 13C18 is the 13C labeled Ethyl linoleate. Ethyl linoleate inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators[1].
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- HY-B0143S3
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Niacin- 13C6 is the 13C-labeled Niacin. Niacin (Nicotinic acid) is a vitamin and is part of the vitamin B group.
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- HY-B0216S2
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Ethynyl Estradiol- 13C2 is the 13C-labeled Ethynyl Estradiol. Ethynyl Estradiol-13C2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-N0680S3
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Thiamine- 13C3 (hydrochloride) is the 13C-labeled Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.
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- HY-A0181S
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Adenosine monophosphate- 13C10, 15N5 is the 13C-labeled and 15N-labeled Adenosine monophosphate. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction[1].
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- HY-Y0978S2
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Boc-Glycine-2- 13C is a 13C-labeled Linuron. Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive a
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- HY-B0688S2
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Dapsone- 13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al [5].
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- HY-10163S2
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Dabigatran- 13C6 is the 13C labeled Dabigatran[1]. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[2][3].
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- HY-N0304S1
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L-DOPA- 13C6 is the 13C-labled L-DOPA . L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .
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- HY-N0543S
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Allantoin- 13C2, 15N4 is the 13C and 15N labeled Allantoin[1]. Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth[2].
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- HY-W040055S
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Neopterin- 13C5 (D-(+)-Neopterin- 13C5; D-erythro-Neopterin- 13C5)is the deuterium labeledNeopterin(HY-W040055) . Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation .
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- HY-14605S
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Rasagiline- 13C3 ((R)-AGN1135- 13C3; TVP1012- 13C3) mesylateis the deuterium labeledRasagiline (mesylate)(HY-14605) . Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43?nM and 412?nM for rat brain MAO B and A activity, respectively .
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- HY-13078S
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Cobimetinib- 13C6 (GDC-0973- 13C6; XL518- 13C6) racemateis the deuterium labeledCobimetinib (racemate)(HY-13078) . Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor .
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- HY-B0152S3
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Adenine- 13C5 (6-Aminopurine- 13C5; Vitamin B4- 13C5) is 13C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA.
Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
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- HY-B0152S4
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Adenine- 15N5 (6-Aminopurine- 15N5; Vitamin B4- 15N5) is 15N labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA.
Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
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- HY-111095S2
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D-(-)-Lactic acid- 13C-1 is the 13C labeled D-(-)-Lactic acid. D-(-)-Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. D-(-)-Lactic acid is identified to be a competitive inhibitor of ProDH (proline dehydrogenase) in plants .
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- HY-111095S3A
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D-(-)-Lactic acid-13C-2 (sodium) is a sodium. D-(-)-Lactic acid-13C-2 (sodium) can be used for a variety of biochemical studies.
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- HY-12956S2
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Dinoprost- 13C5 is 13C labeled Dinoprost (HY-12956). Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
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- HY-112499S1
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Menaquinone-7- 13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].
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- HY-108213S1
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Inosinic acid- 15N4 dilithium (5'-IMP-15N4 (dilithium); IMP-15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-15N4 (dilithium)) is 15N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .
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- HY-13318S1
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Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC50=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections [5].
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- HY-Y0921S3
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(±)-1,2-Propanediol- 13C3 is 13C labeled (±)-1,2-Propanediol (HY-Y0921). (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish .
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- HY-N1415S1
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β-Caryophyllene- 13C,d2 is 13C and deuterated labeled trans,trans-2,4-Decadienal (HY-W013627). trans,trans-2,4-Decadienal is a lipid peroxidation product of linolieic acid .
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- HY-14605BS
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Rasagiline- 13C3 (mesylate racemic) is a 13C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1]. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-90001S1
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Ritonavir- 13C,d3 is the 13C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
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- HY-B0891S1
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17α-Hydroxyprogesterone- 13C3 is the 13C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
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- HY-16637S3
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Folic acid- 13C5 is the 13C-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
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- HY-N0215S11
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L-Phenylalanine- 13C9, 15N is the 13C- and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
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- HY-N0455AS8
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L-Arginine- 13C6, 15N4 (hydrochloride) is the 13C- and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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- HY-12033S1
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2-Methoxyestradiol- 13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].
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- HY-B0166S
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L-Ascorbic acid- 13C6 is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
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- HY-100427S
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Imazamox- 13C,d3 is the 13C- and deuterium labeled Imazamox. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death[1][2].
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- HY-17034AS
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Dexmedetomidine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].
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- HY-B0508S1
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Ornidazole- 13C2, 15N2 is the 13C, 15N labeled Ornidazole. Ornidazole(Ro 7-0207) is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria.
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- HY-A0132S8
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N-Acetyl-D-glucosamine- 13C, 15N is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
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- HY-B0158S2
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Cytidine- 13C-1 is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami
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- HY-N0378S6
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D-Mannitol- 13C,d2 is the deuterium and 13C labeled D-Mannitol.
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- HY-15772S1
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Osimertinib- 13C,d3 is the deuterium and 13C labeled Osimertinib. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively.
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- HY-13690S1
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Mitotane- 13C6 is the 13C labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].
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- HY-90006S3
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5-Fluorouracil- 13C4, 15N2 is the 13C and 15N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].
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- HY-B2176S
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ATP- 13C10, 15N5 is the 13C and 15N labeled ATP[1]. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[2][3].
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- HY-W012926S
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Dihydrouracil- 13C4, 15N2 is the 13C and 15N labeled Dihydrouracil[1]. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].
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- HY-103447S1
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Zearalenone- 13C18 (Mycotoxin F2- 13C18; Toxin F2- 13C18) is the 13C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
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- HY-10219S1
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Rapamycin- 13C,d3 (Sirolimus- 13C,d3; AY-22989- 13C,d3) is the 13C and deuterium labeled Rapamycin (HY-10219) . Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .
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- HY-B1342S3
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Retinol- 13C3 (Vitamin A1- 13C3; all-trans-Retinol- 13C3) is a 13C-labeled Vitamin A/Retinol (HY-B1342). Retinol is an endogenous metabolite.
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- HY-N0086S2
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N6-Methyladenosine- 13C4 (6-Methyladenosine- 13C4; N-Methyladenosine- 13C4) is 13C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.
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- HY-W008642S
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(Leu-13C6,15N)-Leu-OH TFA is a C13 and N15 labeled Leu-Leu-OH TFA. Leu-Leu-OH, a Leu derivative, is a dipeptide .
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- HY-W269700S
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Ile-(Leu-13C6,15N)-OH (TFA) is 13C- and 15N-labeled L-Isoleucyl-L-leucine (HY-W269700). L-Isoleucyl-L-leucine has a role as a metabolite and can be used to inhibit movement-induced muscle damage and muscle defective condition.
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- HY-N0086S3
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N6-Methyladenosine- 13C3 (6-Methyladenosine- 13C3) is 13C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities .
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- HY-W751165
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Uridine-13C9,15N2 (β-Uridine-13C9,15N2) is 13C and 15N labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond .
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-
- HY-13632S5
-
|
Exemestane- 13C,d2 is 13C and deuterated labeled Exemestane (HY-13632). Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
|
-
- HY-B0252S3
-
|
Hydrochlorothiazide- 15N2, 13C,d2 is 15N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
- HY-41417S3
-
|
Octanoic acid- 13C is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-N7092S1
-
|
D-Fructose- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
|
-
- HY-N0455AS7
-
|
L-Arginine- 13C (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-W004260S3
-
|
Arachidic acid- 13C is the 13C labeled Arachidic acid. Arachidic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue .
|
-
- HY-77956S1
-
|
Thyminose- 13C-1 is the 13C labeled Thyminose. Thyminose is an endogenous metabolite[1].
|
-
- HY-77956S2
-
|
Thyminose- 13C-2 is the 13C labeled Thyminose. Thyminose is an endogenous metabolite[1].
|
-
- HY-B1449S1
-
|
Uridine- 13C is the 13C labeled Uridine[1].
|
-
- HY-N0538S
-
|
Xylitol-1- 13C is the 13C labeled Xylit[1][2].
|
-
- HY-N0538S1
-
|
Xylitol-2- 13C is the 13C labeled Xylit[1][2].
|
-
- HY-N0538S2
-
|
Xylitol-5- 13C is the 13C labeled Xylit[1][2].
|
-
- HY-W010042S
-
|
L-Glucose- 13C is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake[1][2].
|
-
- HY-42680S
-
|
D-Tagatose- 13C is the 13C labeled D-Tagatose. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice
|
-
- HY-B1659S2
-
|
Glycerol- 13C-1 is the 13C labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[1][2][3][4].
|
-
- HY-N0210S
-
|
D-Galactose- 13C is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose[1][2][3][4].
|
-
- HY-W012835S2
-
|
4-Methylanisole- 13C is the 13C-labeled 4-Methylanisole. 4-Methylanisole (4-Methoxytoluene) is food flavoring agent and can be naturally found in Ylang Ylang fragrance oil[1].
|
-
- HY-Y0781S1
-
|
Pyruvic acid- 13C is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
|
-
- HY-Y0827S
-
|
Carbonate- 13C (barium) is the 13C labeled Barium carbonate[1].
|
-
- HY-15236S
-
|
PSI-6206- 13C,d3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
|
-
- HY-16938S
-
|
5'-Methylthioadenosine- 13C6 is the 13C-labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].
|
-
- HY-113038AS
-
|
α-Hydroxyglutaric acid- 13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].
|
-
- HY-N0098S
-
|
Vanillin- 13C,d3 is the 13C and deuterium labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
|
-
- HY-10241S
-
|
Simeprevir- 13C,d3 is the 13C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].
|
-
- HY-N1394S
-
|
p-Anisic acid- 13C6 is the 13C-labeled p-Anisic acid. p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties[1].
|
-
- HY-113008AS
-
|
cis-Urocanic acid- 13C3 is the 13C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1].
|
-
- HY-N0650S9
-
|
L-Serine- 15N,d3 is the deuterium and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-N0717S2
-
|
L-Valine- 13C5, 15N,d8 is the deuterium, 13C-, and 15-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
- HY-N0717S3
-
|
L-Valine- 13C5, 15N,d2 is the deuterium, 13C-, and 15-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
- HY-W014423S3
-
|
L-Histidine- 13C6, 15N3 (hydrochloride hydrate) is the 13C- and 15N-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-10999S2
-
|
Trametinib- 13C,d3 is the 13C- and deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].
|
-
- HY-13683S1
-
|
Mifepristone- 13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-15321S1
-
|
Etoricoxib- 13C,d3 is the 13C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
|
-
- HY-B0002BS2
-
|
Ondansetron- 13C,d3 is the 13C- and deuterium labeled Ondansetron[1].
|
-
- HY-B0495S1
-
|
Lamotrigine- 13C,d3 is the 13C- and deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
|
-
- HY-113225S1
-
|
Guanosine triphosphate- 13C10, 15N5 (tetraammonium) is the 13C and 15N labeled Guanosine triphosphate tetraammonium[1]. Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19[2].
|
-
- HY-128738S
-
|
Thymidine-5'-monophosphate- 13C10, 15N2 (disodium) is the 13C and 15N labeled Thymidine-5'-monophosphate disodium salt[1]. Thymidine-5'-monophosphate disodium salt is an endogenous metabolite.
|
-
- HY-18341S4
-
|
L-Thyroxine- 13C6-1 (Levothyroxine- 13C6-1; T4- 13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
|
-
- HY-A0181BS
-
|
Adenosine monophosphate-13C10,15N5 (disodium) is the sodium salt form of Adenosine monophosphate-13C10,15N5. Adenosine monophosphate is a key cellular metabolite that regulates energy homeostasis and signal transduction .
|
-
- HY-16106S
-
|
Talazoparib- 13C,d4 is 13C and deuterated labeled Talazoparib (HY-16106). Talazoparib is an orally active PARP 1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM for inhibiting PARP1 and PARP2 enzymatic activities, respectively. Has anti-tumor activity.
|
-
- HY-W101298S
-
|
(Leu-13C6,15N)-Ile-OH (L-Leucyl-13C6,15N-L-isoleucine) TFA is the deuterium labeled Leu-Ile-OH. Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) synthesis .
|
-
- HY-B0250S1
-
|
Lamivudine-13C,15N2,d2 (BCH-189-13C,15N2,d2) is a 13C, 15N, and deuterium labeled Lamivudine (HY-B0250). Lamivudine is an orally active and blood-brain barrier permeable nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus (HBV) reverse transcriptase .
|
-
- HY-19717S
-
|
DCVC- 13C3, 15N is 15N and 13C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures .
|
-
- HY-B0445S
-
|
NAD+-13C5 (ammonium) is the 13C labled NAD+ (HY-B0445), with an ammonium .
|
-
- HY-17427S2
-
|
Emtricitabine- 13C, 15N2 (BW1592- 13C, 15N2) is a 13C- and 15N-labeled Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.
|
-
- HY-15005S
-
|
Sofosbuvir- 13C,d3 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-N0390S6
-
|
L-Glutamine- 13C5, 15N2 is the 13C- and 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-10163S3
-
|
Dabigatran- 13C,d3 is the 13C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].
|
-
- HY-13629S1
-
|
Etoposide- 13C,d3 is the 13C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy[1].
|
-
- HY-14153AS
-
|
Tegaserod- 13C,d3 (maleate) is the 13C- and deuterium labeled Tegaserod (maleate). Tegaserod maleate is a selective 5-HT4 receptor partial agonist and a 5-HT2B receptor antagonist. Tegaserod maleate exhibits a promotile effect throughout the gastrointestinal (GI) tract[1][2][5].
|
-
- HY-B0957S
-
|
Erythromycin ethylsuccinate- 13C,d3 is the 13C- and deuterium labeled Erythromycin Ethylsuccinate. Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.
|
-
- HY-G0007S1
-
|
Omeprazole metabolite Omeprazole sulfone- 13C,d3 is the deuterium and 13C labeled Omeprazole metabolite Omeprazole sulfone[1].
|
-
- HY-A0132S11
-
|
N-Acetyl-D-glucosamine- 13C, 15N-1 is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-B2176S1
-
|
ATP- 13C10, 15N5 (disodium) is a 13C-labeled and 15N-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[1][2][3][4].
|
-
- HY-Y1069S3
-
|
(S)-Malic acid- 13C4 is the 13C labeled S-Malic acid (HY-Y1069)[1].
|
-
- HY-N0610AS2
-
|
Cinnamic acid- 13C3 (3-Phenylacrylic acid- 13C3) is the 13C labeled Cinnamic acid (HY-N0610A). Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells .
|
-
- HY-18569S4
-
|
3-Indoleacetic acid- 13C6 is the 13C labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.
|
-
- HY-W013159S
-
|
2'-Deoxyguanosine 5'-monophosphate- 13C10, 15N5 (disodium) is the 13C and 15N labeled 2'-Deoxyguanosine 5'-monophosphate disodium[1]. 2'-Deoxyguanosine 5'-monophosphate disodium (5′-dGMP disodium) is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative[2].
|
-
- HY-W010918S1
-
|
Adenosine 5'-diphosphate- 13C10 (Adenosine diphosphate- 13C10 dilithium; ADP- 13C10) dilithium is 13C-labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
|
-
- HY-W010918S2
-
|
Adenosine 5'-diphosphate- 15N5 (Adenosine diphosphate- 15N5 dilithium; ADP- 15N5) dilithium is 15N labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
|
-
- HY-138615S4
-
|
Deoxythymidine-5'-triphosphate- 13C10, 15N2 (dTTP- 13C10, 15N2) dilithium is 13C and 15N-labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
|
-
- HY-B2236S2
-
|
DL-Lysine- 13C6, 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6, 15N2 hydrochloride) is 13C and 15N-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-113066S3
-
|
Guanosine 5'-diphosphate- 13C10, 15N5 (GDP- 13C10, 15N5) dilithium is 13C and 15N-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
|
-
- HY-107372S2
-
|
Uridine triphosphate- 13C9 (UTP- 13C9 dilithium; Uridine 5'-triphosphate- 13C9) dilithium is 13C-labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
|
-
- HY-107372S4
-
|
Uridine triphosphate- 15N2 (UTP- 15N2 dilithium; Uridine 5'-triphosphate- 15N2) dilithium is 15N labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
|
-
- HY-Y0781S
-
|
Pyruvic acid- 13C (sodium) is the 13C-labeled Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
|
-
- HY-W014423S
-
|
L-Histidine- 13C (hydrochloride hydrate) is the 13C-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-W014423S6
-
|
L-Histidine- 15N (hydrochloride hydrate) is the 15N-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-W016562S3
-
|
Hippuric acid- 15N is the 15N-labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
|
-
- HY-113365S1
-
|
Cholestenone- 13C is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2][3].
|
-
- HY-42682S1
-
|
D(+)-Galactosamine- 13C (hydrochloride) is the 13C labeled D(+)-Galactosamine hydrochloride. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and
|
-
- HY-N1420AS2
-
|
Rhamnose- 13C-2 (monohydrate) is the 13C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate
|
-
- HY-B2227BS3
-
|
Lactate- 13C-1 (sodium) is the 13C labeled Lactate (sodium)[1]. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium functions in a variety of biochemical processes[2].
|
-
- HY-W088065S
-
|
Formate- 13C (sodium) is the 13C labeled Sodium formate[1].
|
-
- HY-113225S2
-
|
Guanosine triphosphate- 13C (GTP- 13C) dilithium is 13C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
|
-
- HY-P10324
-
|
TAT-p16 (p16INK4a peptide) is a peptide mimic of p16INK4a that can induce an early G phase cell cycle arrest in the absence of active cyclin E:Cdk2 complex .
|
-
- HY-Y0045S
-
|
2-Acetylthiazole- 13C2 is 13C labeled Fructose-phenylalanine.
|
-
- HY-N0683S
-
|
α-Vitamin E- 13C6 is the 13C-labeled α-Vitamin E. α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant[1][2].
|
-
- HY-B2156S1
-
|
Menaquinone-4- 13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
|
-
- HY-N0683S1
-
|
α-Vitamin E- 13C3 is the 13C-labeled α-Vitamin E. α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant[1][2].
|
-
- HY-N1446S2
-
|
Oleic acid- 13C18 is the 13C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].
|
-
- HY-101541S1
-
|
Docosahexaenoic acid- 13C22 methyl ester is the 13C22 labeled Docosahexaenoic acid methyl ester (HY-101541)[1].
|
-
- HY-136648S
-
|
2'-Deoxyadenosine-5'-triphosphate- 13C10, 15N5 (tetraammonia) is the 13C10 ans 15N5 labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648)[1].
|
-
- HY-121259S
-
|
Doxorubicinol- 13C,d3 (TFA) is the deuterium and 13C labeled Doxorubicinol TFA[1].
|
-
- HY-W013059S
-
|
DMT-dA(bz) Phosphoramidite- 13C10, 15N5 is the 13C and 15N labeled DMT-dA(bz) Phosphoramidite[1]. DMT-dA(bz) Phosphoramidite is typically used in the synthesis of DNA[2].
|
-
- HY-W654078
-
|
Bisphenol AF- 13C12 is an isotopic label of Bisphenol AF. Bisphenol AF is used in polycarbonate plastic and epoxy resin manufacturing. Bisphenol AF can significantly increase intracellular ROS levels .
|
-
- HY-Y0051S
-
|
5-Hydroxymethylfurfural- 13C6 (2-Hydroxymethyl-5-furfural- 13C6; 2-Formyl-5-hydroxymethylfuran- 13C6) is a 13C labeled 5-Hydroxymethylfurfural (HY-Y0051). 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
|
-
- HY-136648S1
-
|
2'-Deoxyadenosine-5'-triphosphate- 13C10, 15N5 (dATP- 13C10, 15N5) dilithium is 13C and 15N-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
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-
- HY-125818S3
-
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Cytidine-5'-triphosphate- 13C9 (Cytidine triphosphate- 13C9 dilithium; 5'-CTP- 13C9) dilithium is 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
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-
- HY-125818S6
-
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Cytidine-5'-triphosphate- 15N3 (Cytidine triphosphate- 15N3 dilithium; 5'-CTP- 15N3) dilithium is 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
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-
- HY-101400S4
-
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Deoxycytidine triphosphate- 13C9 (dCTP- 13C9 dilithium; 2′-Deoxycytidine-5′-triphosphate- 13C9) dilithium is 13C-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
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-
- HY-101400S3
-
|
Deoxycytidine triphosphate- 15N3 (dCTP- 15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate- 15N3) dilithium is 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
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-
- HY-138616S4
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dGTP- 13C10, 15N5 (2'-Deoxyguanosine-5'-triphosphate- 13C10, 15N5) dilithium is 13C and 15N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
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-
- HY-W392933S4
-
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Thymidine 5'-monophosphate- 13C10, 15N2 (Thymidine-5'-phosphate- 13C10, 15N2) dilithium is 13C and 15N-labeled Thymidine 5'-monophosphate (HY-W392933).
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-
- HY-B0389S
-
|
D-Glucose- 13C6,d7 is the deuterium and 13C labeled D-Glucose[1].
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-
- HY-Y1088S
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Hydrocinnamic acid-2,3- 13C2 is the 13C-labeled Hydrocinnamic acid. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities.
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-
- HY-B0389S22
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D-Glucose- 13C2,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si
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- HY-B0579S3
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Cyclosporin A- 13C2,d4 (Cyclosporine A- 13C2,d4; Ciclosporin A- 13C2,d4) is a 13C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .
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-
- HY-N0229S5
-
|
L-Alanine- 13C3, 15N,d4 is the deuterium, 13C-, and 15-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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- HY-A0132S9
-
|
N-Acetyl-D-glucosamine- 13C3, 15N is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
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-
- HY-A0132S10
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N-Acetyl-D-glucosamine- 13C2, 15N is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
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-
- HY-B0158S6
-
|
Cytidine- 15N3 is the 15N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].
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-
- HY-A0132S13
-
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N-Acetyl-D-glucosamine- 13C8, 15N is 13C and 15N labeled N-Acetyl-D-glucosamine (HY-A0132). N-Acetyl-D-glucosamine is a monosaccharide derivative of glucose.
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-
- HY-N5134S1
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5'-Guanylic acid- 13C10 (5'-GMP- 13C10 dilithium; 5'-guanosine monophosphate- 13C10) dilithium is 13C-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
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-
- HY-N5134S2
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5'-Guanylic acid- 15N5 (5'-GMP- 15N5 dilithium; 5'-guanosine monophosphate- 15N5) dilithium is 15N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
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-
- HY-W009162S1
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Cytidine 5′-monophosphate- 13C9 (5'-Cytidylic acid- 13C9 dilithium; 5'-CMP- 13C9) dilithium is 13C-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
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-
- HY-W009162S4
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Cytidine 5′-monophosphate- 15N3 (5'-Cytidylic acid- 15N3 dilithium; 5'-CMP- 15N3) dilithium is 15N labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
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-
- HY-W048482S1
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rU Phosphoramidite- 13C9, 15N2 (DMT-2'O-TBDMS-rU phosphoramidite- 13C9, 15N2) is 13C and 15N-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
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- HY-101981S3
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Uridine 5'-monophosphate- 13C9, 15N2 (5'-?Uridylic acid- 13C9, 15N2) dilithium is 13C and 15N-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
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-
- HY-B0158S7
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Cytidine- 13C9 (Cytosine β-D-riboside- 13C9; Cytosine-1-β-D-ribofuranoside- 13C9) is 13C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .
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-
- HY-N0390S
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L-Glutamine- 15N is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
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-
- HY-B0434S
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Ribavirin- 13C5 is the 13C-labeled Ribavirin. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV.
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-
- HY-19821S
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Fmoc-Ile-OH- 15N is the 15N labeled Fmoc-Ile-OH[1].
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-
- HY-B0337S2
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Sulfadimethoxine- 13C6 is the 13C-labeled Sulfadimethoxine. Sulfadimethoxine (Sulphadimethoxine) is a sulfonamide antibiotic used to treat many infections[1][2].
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-
- HY-B0412S3
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Estriol- 13C3 is the 13C-labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
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-
- HY-N0229S2
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L-Alanine- 15N is the 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system[1].
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-
- HY-N7092S2
-
|
D-Fructose- 13C-1 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
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-
- HY-N0455AS3
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L-Arginine-1- 13C (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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-
- HY-B0467AS
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Amoxicillin- 13C6 is the 13C6 labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity.
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-
- HY-B1781S
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Sulfachloropyridazine- 13C6 is the 13C6 labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria.
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-
- HY-N7123S1
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Sulfacetamide- 13C6 is the 13C6 labeled Sulfacetamide. Sulfacetamide (Sulphacetamide), a bacteriostatic sulphonamide, is a popular antibiotic prescribed for treating ocular infections.
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- HY-N7092S4
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D-Fructose-3- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
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- HY-N7092S5
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D-Fructose-4- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
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-
- HY-N7092S6
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D-Fructose-5- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
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-
- HY-N7092S7
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D-Fructose-6- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
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- HY-N7092S20
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D(-)-Fructose- 18O-1 is the 18O labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
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- HY-N7092S21
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D-Fructose- 18O-2 is the 18O labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
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- HY-B1449S2
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Uridine- 13C-1 is the 13C labeled Uridine[1].
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-
- HY-B1449S3
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Uridine- 13C-2 is the 13C labeled Uridine[1].
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-
- HY-B1449S4
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Uridine- 13C-3 is the 13C labeled Uridine[1].
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-
- HY-W010042S1
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L-Glucose- 13C-1 is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake[1][2].
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-
- HY-W010042S2
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L-Glucose- 13C-2 is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake[1][2].
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- HY-42680S1
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D-Tagatose- 13C-1 is the 13C labeled D-Tagatose. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit jui
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-
- HY-78139S
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L-Xylose-1- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
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- HY-78139S1
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L-Xylose-2- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
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-
- HY-78139S2
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L-Xylose-5- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
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-
- HY-N0210S1
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D-Galactose- 13C-2 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose[1][2][3][4].
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- HY-N0210S2
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D-Galactose- 13C-3 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose[1][2][3][4].
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-
- HY-N0210S3
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D-Galactose- 13C-4 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose[1][2][3][4].
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- HY-N0210S4
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D-Galactose- 13C-5 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose[1][2][3][4].
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- HY-B0252S2
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Hydrochlorothiazide- 13C6 is the 13C labeled Hydrochlorothiazide[1]. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[2][3][4].
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-
- HY-B1449S7
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Uridine 13C-4 is the 13C labeled Uridine[1].
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-
- HY-B1659S4
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Glycerol- 13C2 is the 13C labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].
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- HY-B1659S5
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Glycerol- 13C3 is the 13C labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].
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- HY-N0666S10
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L-Aspartic acid- 13C-1 is the deuterium labeled L-Aspartic acid[1]. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly[2][3].
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- HY-N2362S5
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DL-Alanine- 15N is the 15N labeled DL-Alanine[1]. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[2][3][4][5][6][7].
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- HY-Y0781S3
-
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Pyruvic acid- 13C-2 (sodium) is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
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-
- HY-N6779S
-
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Patulin- 13C7 (Terinin- 13C7) is the 13C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage [5].
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-
- HY-N6746S1
-
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Citrinin- 13C13 (NSC 186- 13C13) is the 13C labeled Citrinin (HY-N6746) . Citrinin is a mycotoxin which causes contamination in the food and is associated with different toxic effects. Citrinin is usually found together with another nephrotoxic mycotoxin, Ochratoxin A. Citrinin is also reported to possess a broad spectrum of bioactivities, including antibacterial, antifungal, and potential anticancer and neuro-protective effects in vitro .
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- HY-78131S3
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Ibuprofen- 13C6 ((±)-Ibuprofen- 13C6) is a 13C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers [5].
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-
- HY-W777457
-
|
Anthracene- 13C6 (Anthracin- 13C6) is 13C labeled Anthracene-13C6 (HY-W777457).
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- HY-B2176S2
-
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ATP- 13C (Adenosine 5'-triphosphate- 13C) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
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- HY-113066S2
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Guanosine 5'-diphosphate-d13 (GDP-d13) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
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- HY-N0136S1
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(±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3) is a derivative of (±)-Taxifolin, labeled with 13C3. (±)-Taxifolin is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
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-
- HY-B0111RS
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Drospirenone- 13C3 is 13C labeled Drospirenone. Drospirenone (Dihydrospirorenone) is a synthetic progesterone that is an analog of Spironolactone .
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- HY-B0228S10
-
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(R)-3-Hydroxybutanoic acid- 13C2 (sodium) is the 13C labeled (R)-3-Hydroxybutanoic acid (sodium) (HY-W015851). (R)-3-Hydroxybutanoic acid (sodium) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2][3].
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-
- HY-W015851S2
-
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(R)-3-Hydroxybutanoic acid-13C4 (sodium) is an active compound. (R)-3-Hydroxybutanoic acid-13C4 (sodium) can be used for kinds of research.
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-
- HY-W393970S3
-
|
2′-Deoxyguanosine 5′-monophosphate- 13C10, 15N5 (5'-Deoxyguanylic acid- 13C10, 15N5) dilithium is 13C and 15N-labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
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- HY-N0215S9
-
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L-Phenylalanine- 13C9, 15N,d8 is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
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-
- HY-N0455AS4
-
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L-Arginine- 13C6, 15N4,d7 (hydrochloride) is the deuterium, 13C-, and 15-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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-
- HY-W050145S2
-
|
Levoglucosan- 13C6 is the 13C labeled Levoglucosan[1]. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature[2].
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-
- HY-B0289S
-
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Erdosteine- 13C4 is a 13C-labeled Erdosteine. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation[1][2]. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[3].
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-
- HY-W015913S
-
|
Sodium 2-oxopropanoate- 13C3 is the 13C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].
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- HY-139145S
-
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Etbicyphat- 13C3 is the 13C labeled Etbicyphat (HY-139145). Etbicyphat is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors[1][2].
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-
- HY-12857S
-
|
Brigatinib- 13C6 is the 13C-labeled Brigatinib. Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor, with an IC50 of 0.6 nM[1].
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- HY-N0717S6
-
|
L-Valine- 13C5 is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
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- HY-113251S1
-
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2-Hydroxyestrone- 13C6 is the 13C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].
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-
- HY-100532S
-
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CD437- 13C6 is the 13C- and deuterium labeled CD437. CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.
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-
- HY-117275S1
-
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Meclofenamic acid- 13C6 is the 13C6 labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
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-
- HY-12542S
-
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Dantrolene- 13C3 is the 13C3 labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
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- HY-15037S2
-
|
Diclofenac- 13C6 (Sodium) is the 13C6 labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
|
-
- HY-B0497S1
-
|
Niclosamide- 13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
|
-
- HY-B0975S
-
|
Penicillin V- 13C6 (potassium) is the 13C6 labeled Penicillin V (potassium). Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis.
|
-
- HY-15926S
-
|
ONPG- 13C is the 13C labeled ONPG. ONPG is a colorimetric and spectrophotometric substrate for detection of β-galactosidase activit[1][2].
|
-
- HY-150679S
-
|
Remdesivir- 13C6 is the 13C labeled Remdesivir[1].
|
-
- HY-B0285AS
-
|
Amiloride- 15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.
|
-
- HY-B0497BS
-
|
Niclosamide- 13C6 (monohydrate) is the 13C labeled Niclosamide monohydrate[1]. Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[2]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[5]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[3][4][6].
|
-
- HY-B0892S3
-
|
Benzyl alcohol- 13C6 is the 13C labeled Benzyl alcohol[1].
|
-
- HY-B1409S
-
|
Isosorbide dinitrate- 13C6 is the 13C labeled Isosorbide dinitrate[1]. Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI)[2].
|
-
- HY-B1779S5
-
|
Sucrose-13C6 is the 13C labeled Sucrose[1]. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al[2].
|
-
- HY-N1380S2
-
|
Guaiacol- 13C6 is the 13C labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].
|
-
- HY-B0421S2
-
|
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
|
-
- HY-W013636S3
-
|
2-Ketoglutaric acid- 13C (Alpha-Ketoglutaric acid- 13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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-
- HY-13407S
-
|
Gossypol-13C2 (BL 193-13C2) is an active compound. Gossypol-13C2 can be used for kinds of research.
|
-
- HY-B1422S
-
|
9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-15407S3
-
|
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 [5].
|
-
- HY-109120S1
-
|
Odevixibat- 13C6 is 13C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .
|
-
- HY-N7093S
-
|
Furaneol- 13C2 is 13C labeled Nonanal (HY-N8016). Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity .
|
-
- HY-N0623S6
-
|
L-Tryptophan- 15N2,d8 is the deuterium and 15N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
|
-
- HY-W014423S1
-
|
L-Histidine- 13C6, 15N3,d5 (hydrochloride hydrate) is the deuterium, 13C-, and 15-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-A0181S4
-
|
Adenosine monophosphate- 13C10, 15N5,d12 (AMP- 13C10, 15N5,d12) dilithium is 13C and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
|
-
- HY-B0495S
-
|
Lamotrigine- 13C3,d3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
|
-
- HY-N0390S3
-
|
L-Glutamine- 13C5, 15N2,d5 is the deuterium, 13C-, and 15-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-P0265AS
-
|
β-Amyloid- 15N (1-40) (TFA) is the 15N-labledβ-Amyloid (1-40) (TFA). β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease[1].
|
-
- HY-N0215S2
-
|
L-Phenylalanine- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
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-
- HY-B0113S3
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|
Omeprazole- 13C,d3 is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].
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-
- HY-W007318S
-
|
2-Iodoaniline- 13C6 is the 13C labeled 2-Iodoaniline[1].
|
-
- HY-N0455AS
-
|
L-Arginine- 15N2 (hydrochloride) is the 15N-labeled L-Arginine (hydrochloride). L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-N0229S1
-
|
L-Alanine-1- 13C is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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-
- HY-W015824S2
-
|
DL-Aspartic acid-3- 13C is the 13C labeled DL-Aspartic acid[1].
|
-
- HY-N0455AS1
-
|
L-Arginine- 15N4 (hydrochloride) is the 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis[1].
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-
- HY-N0215S5
-
|
L-Phenylalanine- 15N is the 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
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-
- HY-41417S4
-
|
Octanoic acid- 13C4 is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
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-
- HY-N7092S
-
|
D-Fructose- 13C6 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
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-
- HY-N0229S6
-
|
L-Alanine-3- 13C is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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-
- HY-N0229S7
-
|
L-Alanine-2- 13C is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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-
- HY-N0390S4
-
|
L-Glutamine-5- 13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
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-
- HY-N0390S5
-
|
L-Glutamine-1- 13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
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-
- HY-N0390S9
-
|
L-Glutamine- 15N-1 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
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-
- HY-N0455AS6
-
|
L-Arginine- 13C6 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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-
- HY-N2362S
-
|
DL-Alanine- 13C-1 is the 13C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].
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-
- HY-N2362S1
-
|
DL-Alanine- 13C-3 is the 13C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].
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-
- HY-B0351S1
-
|
Taurine- 13C2 is the 13C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes[1][2][3].
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-
- HY-19528S1
-
|
SAH- 13C5 is the 13C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].
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-
- HY-N0390S11
-
|
L-Glutamine-2- 13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
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-
- HY-78131S1
-
|
Ibuprofen- 13C,d3 is the 13C- and deuterium labeled Ibuprofen. Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
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-
- HY-B0252S1
-
|
Hydrochlorothiazid- 13C,d2 is the 13C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].
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-
- HY-B0330S2
-
|
Levofloxacin- 13C,d3 is the 13C- and deuterium labeled Levofloxacin.
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-
- HY-B0335S1
-
|
Tolfenamic acid- 13C6 is the 13C6 labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
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-
- HY-W069721S1
-
|
N-Acetylsulfanilamide- 13C6 is the 13C6 labeled N-Acetylsulfanilamide.
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-
- HY-N7032S
-
|
Uridine 5′-diphosphoglucose- 13C (disodium) is the 13C labeled Uridine 5′-diphosphoglucose disodium salt. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycop
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-
- HY-N0210S16
-
|
D-Galactose- 13C6 is the deuterium labeled D-Galactose (HY-N0210). D-Galactose is a natural aldohexose and C-4 epimer of glucose[1][2].
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-
- HY-14781S2
-
|
Levomefolic acid- 13C5 is the 13C labeled Levomefolic acid[1]. Levomefolic acid (5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements[2][3].
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-
- HY-B1449S
-
|
Uridine- 15N2 is the 15N labeled Uridine[1].
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-
- HY-B1449S10
-
|
Uridine- 13C5 (β-Uridine- 13C5) is a 13C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.
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-
- HY-W007376S
-
|
Indole-3-carboxaldehyde- 13C (3-Formylindole- 13C) is a 13C labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin .
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-
- HY-W778203
-
|
Glycolic acid- 13C2 is the 13C-labeled Glycolic acid (HY-W015967). Glycolic acid- 13C2 is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
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-
- HY-N7092S22
-
|
D-Fructose- 13C3 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
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-
- HY-N7092S24
-
|
D-Fructose- 13C4 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-W048482S4
-
|
rU Phosphoramidite- 15N (DMT-2'O-TBDMS-rU phosphoramidite- 15N) is 15N labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-W753983
-
|
Pyruvic acid-13C is isotype-labeled compound of Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .
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-
- HY-W010042S3
-
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L-Glucose- 13C6 (L-(-)-Glucose- 13C6) is C13-labeled L-Glucose. L-Glucose is an enantiomer of D-glucose. L-Glucose enhances food intake .
|
-
- HY-B1449S11
-
|
Uridine-13C9 (β-Uridine-13C9) is a 13C9-labeled form of Uridine (HY-B1449). Uridine (β-Uridine) is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond .
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-
- HY-N0803S1
-
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Myrcene- 13C3 is 13C labeled trans-2-Decenal (HY-W015551). trans-2-Decenal is an important raw material and intermediate used in organic synthesis, medicine, pesticides and dyes.
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-
- HY-W020678S
-
|
2-Methylbutanal- 13C2 is 13C labeled Ethyl 2-methylbutanoate.
|
-
- HY-W334800S
-
|
(2S,6S)-2,6-Diaminoheptanedioic acid- 13C7, 15N2 (L-threo-2,6-Diaminopimelic acid- 13C7, 15N2) is 13C and 15N-labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).
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-
- HY-10065S
-
|
Axitinib- 13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.
|
-
- HY-17427S
-
|
Emtricitabine- 15N,d2 is a 15N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.
|
-
- HY-W014632S
-
|
4-Trifluoromethylsalicylic acid- 13C6 is the 13C labeled 4-Trifluoromethylsalicylic acid[1]. 4-Trifluoromethylsalicylic acid is a platelet aggregation inhibitor[2].
|
-
- HY-A0023AS
-
|
Alogliptin- 13C,d3 is the deuterium labeled Alogliptin. Alogliptin is a potent and selective inhibitor of DPP-4.
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-
- HY-15407AS
-
|
Sacubitril- 13C4 (hemicalcium salt) is a 13C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696[1].
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-
- HY-15605S
-
|
Encorafenib- 13C,d3 is the 13C- and deuterium labeled Encorafenib. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).
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-
- HY-10805S
-
|
Almorexant- 13C,d3 is the 13C- and deuterium labeled Almorexant. Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.
|
-
- HY-17506S1
-
|
Azithromycin- 13C,d3 is the deuterium and 13C labeled Azithromycin[1].
|
-
- HY-W014423S2
-
|
L-Histidine- 13C6 (hydrochloride hydrate) is the 13C-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-W014423S5
-
|
L-Histidine- 15N3 (hydrochloride hydrate) is the 15N-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-10284S1
-
|
Linagliptin- 13C,d3 is the 13C- and deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. Linagliptin-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-10582S2
-
|
Flurbiprofen- 13C,d3 is the 13C- and deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].
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-
- HY-113365S2
-
|
Cholestenone- 13C2 is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2][3].
|
-
- HY-13955S2
-
|
Telmisartan- 13C,d3 is the 13C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
|
-
- HY-14369S
-
|
Elagolix- 13C,d3 (sodium) is the 13C- and deuterium labeled Elagolix sodium. Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
|
-
- HY-16060S2
-
|
Apalutamide- 13C,d3 is the 13C- and deuterium labeled Apalutamide. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].
|
-
- HY-17396S
-
|
Butenafine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
|
-
- HY-17492S1
-
|
Zafirlukast- 13C,d3 is the 13C- and deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
|
-
- HY-17492S2
-
|
Zafirlukast- 13C,d6 is the 13C- and deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
|
-
- HY-18252S
-
|
Avanafil- 13C,d3 is the 13C- and deuterium labeled Avanafil.
|
-
- HY-50904S1
-
|
Nintedanib- 13C,d3 is the 13C- and deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
|
-
- HY-A0166S
-
|
Cilastatin- 15N,d3 is a 15N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct[1][2][3].
|
-
- HY-B0165AS
-
|
Pravastatin- 13C,d3 (sodium) is the 13C- and deuterium labeled Pravastatin (sodium). Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
|
-
- HY-B0192S1
-
|
Alfuzosin- 13C,d3 is the 13C- and deuterium labeled Alfuzosin.
|
-
- HY-B0227S2
-
|
Ketoprofen- 13C,d3 is the 13C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].
|
-
- HY-B0621S1
-
|
Triclabendazole- 13C,d3 is the 13C- and deuterium labeled Triclabendazole[1].
|
-
- HY-B0740S1
-
|
Cyclobenzaprine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Cyclobenzaprine (hydrochloride).
|
-
- HY-W009300S1
-
|
4-Hydroxyestrone- 13C6 is a 13C-labeled Hypoxanthine. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
|
-
- HY-B0263S1
-
|
Thiabendazole- 13C6 is the 13C6 labeled Thiabendazole. Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.
|
-
- HY-W014225S
-
|
3-Phenoxybenzoic acid- 13C6 is the 13C6 labeled 3-Phenoxybenzoic acid. 3-Phenoxybenzoic acid is an endogenous metabolite.
|
-
- HY-B0167S1
-
|
Salicylic acid- 13C6 is the 13C-labeled Salicylic acid (HY-B0167). Salicylic acid is a precursor to and a metabolite of Aspirin (HY-14654), can inhibit cyclo-oxygenase-2 (COX-2) activity[1][2].
|
-
- HY-10888S
-
|
Istradefylline- 13C,d3 is the 13C- and deuterium labeled Istradefylline. Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
|
-
- HY-I0301S
-
|
D-(+)-Glucono-1,5-lactone-1- 13C is the 13C labeled D-(+)-Glucono-1,5-lactone. D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activ[1][2].
|
-
- HY-112174S
-
|
UDP-GlcNAc- 13C (disodium) is the 13C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O[1][2].
|
-
- HY-W010382S
-
|
Oxaloacetic acid- 13C4 is the 13C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis[1][2][3].
|
-
- HY-111772S
-
|
Elexacaftor- 13C,d3 is the deuterium labeled Elexacaftor (HY-111772)[1].
|
-
- HY-10208S1
-
|
Pazopanib- 13C,d3 is the deuterium and 13C labeled Pazopanib[1]. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].
|
-
- HY-12009S
-
|
Pazopanib- 13C,d3 (hydrochloride) is the deuterium and 13C labeled Pazopanib hydrochloride[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].
|
-
- HY-W035903S
-
|
2-Aminoethan-1-ol- 13C2 hydrochloride is the 13C labeled 2-Aminoethan-1-ol hydrochloride[1].
|
-
- HY-W392933S
-
|
Thymidine 5'-monophosphate- 15N2 is the 15N labeled Thymidine 5'-monophosphate[1].
|
-
- HY-14779S
-
|
Riociguat- 13C,d6 is the 13C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
|
-
- HY-B0596S
-
|
Taltirelin- 13C,d3 (TA-0910- 13C,d3) is 13C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca 2+ concentration (Ca 2+ release).
|
-
- HY-N0349S1
-
|
Methyl Paraben- 13C6 (Methyl 4-hydroxybenzoate- 13C6) is a 13C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .
|
-
- HY-W727879
-
|
Upadacitinib- 15N,d2 (ABT-494- 15N,d2) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib- 15N,d2 (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib- 15N,d2 (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib- 15N,d2 (ABT-494) can be used for several autoimmune disorders research .
|
-
- HY-A0181S3
-
|
Adenosine monophosphate- 13C10 (AMP- 13C10) dilithium is 13C-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
|
-
- HY-113225S5
-
|
Guanosine triphosphate- 13C10 (GTP- 13C10) dilithium is 13C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
|
-
- HY-113225S3
-
|
Guanosine triphosphate- 15N5 (GTP- 15N5) dilithium is 15N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
|
-
- HY-W768340
-
|
Sucrose- 13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .
|
-
- HY-106827S1
-
|
Trimegestone- 13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes .
|
-
- HY-14655S1
-
|
Sulfasalazine-d3, 15N is 15N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .
|
-
- HY-B0103AS2
-
|
Fluvoxamine- 13C, d3 maleate is 13C and deuterated labeled Fluvoxamine maleate (HY-B0103A). Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
|
-
- HY-B0374AS
-
|
Moxonidine- 13C,d3 hydrochloride is 13C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) hydrochloride is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.
|
-
- HY-B0250S
-
|
Lamivudine- 15N,d2 is 15N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
- HY-126857AS1
-
|
5-Hydroxyomeprazole- 13C,d2 sodium is 13C and deuterated labeled 5-Hydroxyomeprazole sodium (HY-126857A).
|
-
- HY-W102356S1
-
|
Phenethyl acetate- 13C2 is 13C labeled 2-Methylbutanal.
|
-
- HY-10981S2
-
|
Lenvatinib- 15N,d4 is 15N and deuterated labeled Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities .
|
-
- HY-10353AS1
-
|
Raltegravir- 13C,d3 potassium is 13C labeled Raltegravir potassium (HY-10353A). Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.
|
-
- HY-N0390S1
-
|
L-Glutamine- 13C5 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-50667S
-
|
Apixaban- 13C,d3 is a deuterium and 13C labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1].
|
-
- HY-32351AS1
-
|
Calcifediol- 13C5 (monohydrate) is the 13C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), a major circulating metabolite of vitamin D3, is a potent VDR ligand .
|
-
- HY-W015824S3
-
|
DL-Aspartic acid- 13C1 is the 13C labeled DL-Aspartic acid[1].
|
-
- HY-B0859S
-
|
MCPA- 13C8 is the 13C-labeled MCPA. MCPA is a phenoxy herbicide, and widely used to control annual and perennial broad leaved weeds, including poppy, thistles and docks, in crops such as cereals, rice, linseed, flax, grassland and turf[1][2].
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-
- HY-129242S
-
|
Tempone- 15N,d16 is the deuterium and 15N labeled Tempone[1].
|
-
- HY-10002S
-
|
Calcitriol- 13C3 is the 13C-labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
|
-
- HY-W012722BS1
-
|
4-Methyl-2-oxopentanoic acid- 13C (sodium) is the 13C labeled 4-Methyl-2-oxopentanoic acid sodium[1].
|
-
- HY-113046S
-
|
5-Methyltetrahydrofolic acid- 13C5 is the 13C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid[1].
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-
- HY-N0215S7
-
|
L-Phenylalanine-3- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
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-
- HY-N0229S8
-
|
L-Alanine- 13C3 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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-
- HY-N0229S9
-
|
L-Alanine- 13C2 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-N0390S8
-
|
L-Glutamine- 15N2 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
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-
- HY-10331S1
-
|
Regorafenib- 13C,d3 is the 13C- and deuterium labeled Regorafenib. Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively.
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-
- HY-136450S1
-
|
Triclabendazole sulfoxide- 13C,d3 is the 13C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].
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-
- HY-Y0479AS
-
|
L-Lactic acid- 13C3 (sodium) is the 13C labeled L-Lactic acid. L-Lactic acid- 13C3 sodium can be used for lactate metabolism research[1].
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-
- HY-17453S1
-
|
Salmeterol- 13C6 (xinafoate) is the 13C6 labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.
|
-
- HY-N0210S12
-
|
D-Galactose- 13C,d is the deuterium and 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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-
- HY-N0172S
-
|
Caffeic acid- 13C3 is an 13C labeled caffeic acid. Caffeic acid is a phytonutrient belonging to the flavonoids. Caffeic acid and its derivatives, are potential antimicrobial agents, chronic infection induced by microbes such as bacteria, fungi, and viruses[1].
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-
- HY-100561S
-
|
Tempol-d17, 15N is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS)[2][3].
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-
- HY-101981S
-
|
Uridine 5'-monophosphate-15N2 is the 15N labeled Uridine 5'-monophosphate[1]. Uridine 5'-monophosphate (5'- Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk[2].
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-
- HY-10250S
-
|
Triciribine phosphate-- 13C,d3 is the deuterium and 13C labeled Triciribine phosphate[1].
|
-
- HY-150660S
-
|
25-Hydroxyvitamin D2-(20,21,22,26,27- 13C5) solution is the 13C labeled 25-Hydroxyvitamin D2[1].
|
-
- HY-150663S
-
|
1α,25-Dihydroxyvitamin D3-(23,24,25,26,27- 13C5) solution is the 13C labeled 1α,25-Dihydroxyvitamin D3[1].
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-
- HY-B1075AS
-
|
(Rac)-Fosfomycin (benzylamine)- 13C3 is the 13C labeled Fosfomycin[1]. Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[2][3].
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-
- HY-Y0262BS
-
|
Oxalic Acid- 13C2 (disodium) is the 13C labeled Oxalic Acid disodium[1].
|
-
- HY-N6792S
-
|
T-2 Toxin- 13C24 (T-2 Mycotoxin- 13C24) is 13C-labeled T-2 Toxin (HY-N6792). T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues .
|
-
- HY-126373S1
-
|
SN-38 glucuronide- 13C6 is the 13C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
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-
- HY-14781S1
-
|
Levomefolic acid- 13C,d3is the deuterium labeledLevomefolic acid(HY-14781) . Levomefolic acid (5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements .
|
-
- HY-W017401S
-
|
Benzisothiazolinone-13C5 (1,2-Benzothiazol-3-one-13C5) is a 13C-labeled Benzisothiazolinone. Benzisothiazolinone is widely used as an antiseptic and antibacterial agent .
|
-
- HY-66011AS4
-
|
Moxifloxacin- 13C,d3 hydrochloride (BAY 12-8039- 13C,d3) is 13C and deuterated labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.
|
-
- HY-B1654S
-
|
Flavin adenine dinucleotide- 13C5 (FAD- 13C5) ammonium is 13C labeled Flavin adenine dinucleotide (HY-B1654). Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
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-
- HY-W016814S
-
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(Z)-Aconitic acid- 13C6 is the 13C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
|
-
- HY-N7092S23
-
|
D-Fructose- 13C3-1 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-B2176S6
-
|
ATP- 13C10 (Adenosine 5'-triphosphate- 13C10) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
|
-
- HY-B2176S5
-
|
ATP- 15N5 (Adenosine 5'-triphosphate- 15N5) dilithium is 15N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
|
-
- HY-138615S2
-
|
Deoxythymidine-5'-triphosphate- 13C10 (dTTP- 13C10) dilithium is 13C-labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
|
-
- HY-138615S1
-
|
Deoxythymidine-5'-triphosphate- 15N2 (dTTP- 15N2) dilithium is 15N labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
|
-
- HY-B2236S1
-
|
DL-Lysine- 13C6 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6 hydrochloride) is 13C-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-B2236S3
-
|
DL-Lysine- 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 15N2 hydrochloride) is 15N labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-113066S1
-
|
Guanosine 5'-diphosphate- 13C10 (GDP- 13C10) dilithium is 13C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
|
-
- HY-113066S
-
|
Guanosine 5'-diphosphate- 15N5 (GDP- 15N5) dilithium is 15N labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
|
-
- HY-N0294S1
-
|
Protocatechuic acid- 13C7 is 13C labeled Protocatechuic acid. Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect.
|
-
- HY-W010392S1
-
|
Ethyl 2-methylbutanoate- 13C2 is 13C labeled Tricyclodecenyl acetate.
|
-
- HY-125818S5
-
|
Cytidine-5'-triphosphate- 15N3,d14 (Cytidine triphosphate- 15N3,d14 dilithium; 5'-CTP- 15N3,d14) dilithium is deuterium and 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
|
-
- HY-101400S1
-
|
Deoxycytidine triphosphate- 15N3,d14 (dCTP- 15N3,d14 dilithium; 2′-Deoxycytidine-5′-triphosphate- 15N3,d14) dilithium is deuterium and 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
|
-
- HY-N5134S4
-
|
5'-Guanylic acid- 15N5,d12 (5'-GMP- 15N5,d12 dilithium; 5'-guanosine monophosphate- 15N5,d12) dilithium is deuterium and 15N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
|
-
- HY-W009162S3
-
|
Cytidine 5′-monophosphate- 15N3,d12 (5'-Cytidylic acid- 15N3,d12 dilithium; 5'-CMP- 15N3,d12) dilithium is deuterium and 15N labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
|
-
- HY-18572S
-
|
2,4-D- 13C6 is the 13C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[1].
|
-
- HY-N0437S1
-
|
Progesterone- 13C5 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
|
-
- HY-W097453S
-
|
6-(Methylthio)purine- 13C,d3 is the 13C labeled 6-(Methylthio)purine.
|
-
- HY-N0067S3
-
|
γ-Aminobutyric acid- 13C4 is the 13C-labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
|
-
- HY-N0437S3
-
|
Progesterone- 13C2 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
|
-
- HY-B0033S
-
|
Vigabatrin- 13C,d2 (hydrochloride) is the 13C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].
|
-
- HY-B0640S
-
|
Epinastine- 13C,d3 (hydrobromide) is the 13C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action[1][2][3][4].
|
-
- HY-W014223S
-
|
2,4-Dihydroxybenzophenone- 13C6 (Ultraviolet absorber UV-0- 13C6) is the 13C- and deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone[1].
|
-
- HY-W010452S1
-
|
3-Hydroxybutyric acid- 13C4 (sodium) is the 13C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids[1].
|
-
- HY-W010452S2
-
|
3-Hydroxybutyric acid- 13C2 (sodium) is the 13C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids[1].
|
-
- HY-139427S
-
|
3-Methylglutaconic acid- 13C3 is the 13C labeled 3-Methylglutaconic acid[1].
|
-
- HY-B0152S1
-
|
Adenine- 13C is the 13C labeled Adenine[1]. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[2][3][4].
|
-
- HY-W013059S1
-
|
DMT-dA(bz) Phosphoramidite- 15N5 is the 15N labeled DMT-dA(bz) Phosphoramidite[1]. DMT-dA(bz) Phosphoramidite is typically used in the synthesis of DNA[2].
|
-
- HY-A0023AS2
-
|
Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-136648S5
-
|
2'-Deoxyadenosine-5'-triphosphate- 13C10 (dATP- 13C10) dilithium is 13C-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
|
-
- HY-136648S4
-
|
2'-Deoxyadenosine-5'-triphosphate- 15N5 (dATP- 15N5) dilithium is 15N labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
|
-
- HY-138616S3
-
|
dGTP- 13C10 (2'-Deoxyguanosine-5'-triphosphate- 13C10) dilithium is 13C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
|
-
- HY-W392933S3
-
|
Thymidine 5'-monophosphate- 13C10 (Thymidine-5'-phosphate- 13C10) dilithium is 13C-labeled Thymidine 5'-monophosphate (HY-W392933).
|
-
- HY-W392933S2
-
|
Thymidine 5'-monophosphate- 15N2 (Thymidine-5'-phosphate- 15N2) dilithium is 15N labeled Thymidine 5'-monophosphate (HY-W392933).
|
-
- HY-W343292S
-
|
2-Methylbutyl acetate- 13C2 is 13C labeled 3-Mercaptopentan-2-one.
|
-
- HY-B0203BS2
-
|
(Rac)-Nebivolol-d2, 15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
|
-
- HY-W010696AS
-
|
Reverse T3- 13C6 (hydrochloride) is the 13C labeled Reverse T3[1].
|
-
- HY-B1659S
-
|
Glycerol- 13C3,d8 is the deuterium and 13C labeled Glycerol[1].
|
-
- HY-N0215S10
-
|
L-Phenylalanine- 13C9 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0215S8
-
|
L-Phenylalanine- 13C6 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0229S14
-
|
L-Alanine- 15N,d4 is the deuterium and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-N0229S4
-
|
L-Alanine- 13C,d is the 13C- and deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-N0455AS5
-
|
L-Arginine-1,2- 13C2 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-A0132S4
-
|
N-Acetyl-D-glucosamine- 18O is the 18O labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-A0132S1
-
|
N-Acetyl-D-glucosamine- 13C is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-A0132S7
-
|
N-Acetyl-D-glucosamine- 15N is the 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-B2225AS
-
|
Starch from potato- 13C12 is the 13C-labeled Starch from potato[1].
|
-
- HY-N7032S1
-
|
Uridine 5′-diphosphoglucose- 13C6 (disodium) is the 13C labeled Uridine 5′-diphosphoglucose disodium salt[1]. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR[2].
|
-
- HY-W015851S
-
|
(R)-3-Hydroxybutanoic acid- 13C (sodium) is the 13C labeled (R)-3-Hydroxybutanoic acid sodium[1]. (R)-3-Hydroxybutanoic acid sodium ((R)-3-Hydroxybutyric acid) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[2][3].
|
-
- HY-W048482S2
-
|
rU Phosphoramidite- 13C9 (DMT-2'O-TBDMS-rU phosphoramidite- 13C9) is 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-W048482S3
-
|
rU Phosphoramidite- 15N2 (DMT-2'O-TBDMS-rU phosphoramidite- 15N2) is 15N labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-101981S4
-
|
Uridine 5'-monophosphate- 13C9 (5'-?Uridylic acid- 13C9) dilithium is 13C-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-101981S5
-
|
Uridine 5'-monophosphate- 15N2 (5'-?Uridylic acid- 15N2) dilithium is 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-23506S
-
|
1-Aminoimidazolidine-2,4-dione- 13C3 is 13C labeled 1-Aminoimidazolidine-2,4-dione.
|
-
- HY-50719S1
-
|
2-Acetyl-1-pyrroline- 13C5 is 13C labeled Fenchone.
|
-
- HY-W127515S
-
|
trans-2,cis-6-Nonadienal- 13C2 is 13C labeled 4-Ethylphenol (HY-W012836). 4-Ethylphenol is a volatile phenolic compound associated with off-odour in wine.
|
-
- HY-Y0989S2
-
|
Acetophenone-1,2- 13C2 is the 13C-labeled Acetophenone. Acetophenone is an organic compound with simple structure[1].
|
-
- HY-100441S1
-
|
Treprostinil- 13C2,d is the 13C- and deuterium labeled Treprostinil. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
|
-
- HY-129974S
-
|
3,3'-Diiodo-L-thyronine- 13C6 is the 13C labeled 3,3'-Diiodo-L-thyronine[1]. 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[2][3].
|
-
- HY-W393970S2
-
|
2′-Deoxyguanosine 5′-monophosphate- 13C10 (5'-Deoxyguanylic acid- 13C10) dilithium is 13C-labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
|
-
- HY-W393970S4
-
|
2′-Deoxyguanosine 5′-monophosphate- 15N5 (5'-Deoxyguanylic acid- 15N5) dilithium is 15N labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
|
-
- HY-W001942S2
-
|
DL-2-Methylbutyric acid- 13C2 is 13C labeled 1-(Pyridin-2-yl)ethan-1-one.
|
-
- HY-W012578S1
-
|
2-Isopropyl-3-methoxypyrazine- 13C3 is 13C labeled Octan-2-one.
|
-
- HY-W011090S
-
|
((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate- 13C9, 15N3 (sodium) is the 13C and 15N labeled Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate[1].
|
-
- HY-B1640S
-
|
Ethacrynic acid-13C2,d5 is the deuterium and 13C labeled Ethacrynic acid .
|
-
- HY-N0215S14
-
|
L-Phenylalanine- 15N,d8 is the deuterium and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-N0455AS9
-
|
L-Arginine- 15N4,d7 (hydrochloride) is the deuterium and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-N0390S10
-
|
L-Glutamine-1,2- 13C2 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-32350S
-
|
Ercalcitriol- 13C,d3 is the 13C- and deuterium labeled Ercalcitriol. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.
|
-
- HY-N7092S13
-
|
D-Fructose- 13C6,d7 is the deuterium and 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
|
-
- HY-A0132S2
-
|
N-Acetyl-D-glucosamine- 13C-1 is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-A0132S3
-
|
N-Acetyl-D-glucosamine- 13C-2 is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-A0132S5
-
|
N-Acetyl-D-glucosamine- 13C-3 is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-150661S
-
|
3-Epi-25-hydroxyvitamin D3- 13C5 is the 13C labeled 3-Epi-25-hydroxyvitamin D3[1].
|
-
- HY-Y0836S
-
|
Diethyl succinate- 13C4 is the 13C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
|
-
- HY-B0166S8
-
|
L-Ascorbic acid- 13C6-1 (L-Ascorbate-1; Vitamin C- 13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells [5].
|
-
- HY-100043S
-
|
2-Ethyl-3,5-dimethylpyrazine- 13C2 is 13C labeled Nordiphenhydramine (HY-W585858).
|
-
- HY-B0892S
-
|
Benzyl alcohol-α- 13C-α,α-d2 is the 13C-labeled Benzyl alcohol. Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.
|
-
- HY-P1363S
-
|
β-Amyloid- 15N (1-42), human (TFA) is the 15N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease[1].
|
-
- HY-A0181S5
-
|
Adenosine monophosphate- 15N5,d12 (AMP- 15N5,d12) dilithium is deuterium and 15N labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
|
-
- HY-113225S4
-
|
Guanosine triphosphate- 15N5,d14 (GTP- 15N5,d14) dilithium is deuterium and 15N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
|
-
- HY-W015604S
-
|
2,3-Diethyl-5-methylpyrazine- 13C2 is 13C labeled 4-Hydroxy-5-methylfuran-3(2H)-one.
|
-
- HY-N0390S7
-
|
L-Glutamine- 15N2,d5 is the deuterium and 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-A0132S12
-
|
N-Acetyl-D-glucosamine- 13C6 (N-Acetyl-2-amino-2-deoxy-D-glucose- 13C6) is the 13C labled N-Acetyl-D-glucosamine (HY-A0132) . N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of glucose.
|
-
- HY-B2176S3
-
|
ATP- 15N5,d14 (Adenosine 5'-triphosphate- 15N5,d14) dilithium is deuterium and 15N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
|
-
- HY-138615S3
-
|
Deoxythymidine-5'-triphosphate- 15N2,d15 (dTTP- 15N2,d15) dilithium is deuterium and 15N labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
|
-
- HY-B0712S1
-
|
Ceftriaxone- 13C2,d3 triethylammonium salt is 13C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis [5] .
|
-
- HY-B0094S3
-
|
Artemisinin- 13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
|
-
- HY-B1278AS
-
|
DL-α-Tocopherol acetate- 13C4,d6 is the deuterium and 13C labeled DL-α-Tocopherol acetate[1]. DL-α-Tocopherol acetate is a vitamin E derivative which is often included in the formulations of enteral nutrition[2][3].
|
-
- HY-136648S2
-
|
2'-Deoxyadenosine-5'-triphosphate- 15N5,d14 (dATP- 15N5,d14) dilithium is deuterium and 15N labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
|
-
- HY-138616S2
-
|
dGTP- 15N5,d14 (2'-Deoxyguanosine-5'-triphosphate- 15N5,d14) dilithium is deuterium and 15N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
|
-
- HY-W392933S1
-
|
Thymidine 5'-monophosphate- 15N2,d13 (Thymidine-5'-phosphate- 15N2,d13) dilithium is deuterium and 15N labeled Thymidine 5'-monophosphate (HY-W392933).
|
-
- HY-B0151S1
-
|
Pregnenolone- 13C2,d2 is the deuterium and 13C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[1][2][3][4].
|
-
- HY-W334800S2
-
|
(2S,6S)-2,6-Diaminoheptanedioic acid- 13C7 (L-threo-2,6-Diaminopimelic acid- 13C7) is 13C-labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).
|
-
- HY-W334800S1
-
|
(2S,6S)-2,6-Diaminoheptanedioic acid- 15N2 (L-threo-2,6-Diaminopimelic acid- 15N2) is 15N labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).
|
-
- HY-W048482S
-
|
rU Phosphoramidite- 13C2,d1 (DMT-2'O-TBDMS-rU phosphoramidite- 13C2,d1) is deuterium and 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-101981S1
-
|
Uridine 5'-monophosphate- 15N2,d11 (5'-?Uridylic acid- 15N2,d11) dilithium is deuterium and 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-W393970S
-
|
2′-Deoxyguanosine 5′-monophosphate- 15N5,d12 (5'-Deoxyguanylic acid- 15N5,d12) dilithium is deuterium and 15N labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
|
-
- HY-12650S
-
|
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS .
|
-
- HY-110189S
-
|
Pregnenolone monosulfate (sodium)- 13C2,d2 is the 13C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
|
-
- HY-W156840S
-
|
OTNE- 13C3 is 13C labeled 2-methoxy-4-propylphenol.
|
-
- HY-W249257
-
|
4-Bromobenzoic acid-d4 is the deuterium labeled 4-Bromobenzoic acid-d4[1].
|
-
- HY-W440240
-
|
4-Chlorobenzoic acid-d4 is the deuterium labeled 4-Chlorobenzoic acid-d4[1].
|
-
- HY-W441174
-
|
3-Chlorobenzoic acid-d4 is the deuterium labeled 3-Chlorobenzoic acid-d4[1].
|
-
- HY-113308S
-
|
Taurolithocholic acid-d5 is deuterium labeled Taurolithocholic acid.
|
-
- HY-113308S1
-
|
Taurolithocholic acid-d4 is deuterium labeled Taurolithocholic acid.
|
-
- HY-12769S1
-
|
Mebeverine acid-d5 (hydrochloride) is deuterium labeled Mebeverine acid.
|
-
- HY-B0172S1
-
|
Lithocholic acid-d5 is deuterium labeled Lithocholic acid.
|
-
- HY-154788S
-
|
Losartan acid-d6 hydrochloride is deuterated labeled Losartan acid.
|
-
- HY-18569S
-
1 Publications Verification
|
3-Indoleacetic acid-d5 is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid-d5 can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates[1].
|
-
- HY-W010255S
-
|
Phenylglyoxylic acid-d5 (Benzoylformic acid-d5) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human .
|
-
- HY-78327AS
-
|
(S)-(+)-Modafinic acid-d5 is deuterium labeled (S)-(+)-Modafinic acid.
|
-
- HY-N0384S4
-
|
Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency .
|
-
- HY-B1899BS
-
|
Taurodeoxycholic acid-d4 (sodium) is the deuterium labeled Taurodeoxycholic acid[1].
|
-
- HY-113335S
-
|
Trihydroxycholestanoic acid-d3 is the deuterium labeled Trihydroxycholestanoic acid[1].
|
-
- HY-121238S1
-
|
Hyocholic Acid-d5 is the deuterium labeled Hyocholic Acid[1].
|
-
- HY-132446S
-
|
Metoprolol Acid-d5 is the deuterium labeled Metoprolol Acid[1].
|
-
- HY-76353S
-
|
Pyrazinecarboxylic acid-d3 is the deuterium labeled Pyrazinecarboxylic acid[1].
|
-
- HY-139417S
-
|
Docosapentaenoic acid-d5 is the deuterium labeled Docosapentaenoic acid[1].
|
-
- HY-122141S
-
|
Glycohyocholic acid-d4 is the deuterium labeled Glycohyocholic acid[1].
|
-
- HY-133813S
-
|
Apovincaminic acid-d4 is the deuterium labeled Apovincaminic acid[1].
|
-
- HY-125731S1
-
|
Glycodeoxycholic acid-d6 is the deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is an endogenous metabolite.
|
-
- HY-125731S
-
|
Glycodeoxycholic acid-d4 is the deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is an endogenous metabolite.
|
-
- HY-121238S
-
|
Hyocholic Acid-d4 is the deuterium labeled Hyocholic Acid[1].
|
-
- HY-N7833S
-
|
Heneicosapentaenoic acid-d6 is the deuterium labeled Heneicosapentaenoic acid[1].
|
-
- HY-115340S
-
|
Decanoic acid-d19 (sodium) is the deuterium labeled Decanoic acid[1].
|
-
- HY-132464S1
-
|
Esmolol acid-d7 (sodium) is the deuterium labeled Esmolol acid sodium[1].
|
-
- HY-143924S
-
|
Belinostat acid-d5 is the deuterium labeled Belinostat acid[1].
|
-
- HY-143994S
-
|
Metopimazine acid-d6 hydrochloride is the deuterium labeled Metopimazine acid hydrochloride[1].
|
-
- HY-N0830BS2
-
|
Palmitic acid-d3 (sodium) is the deuterium labeled Palmitic acid[1].
|
-
- HY-N0830BS3
-
|
Palmitic acid-d31 (sodium) is the deuterium labeled almitic acid[1].
|
-
- HY-111973S3
-
|
Phaseic acid-d4 is the deuterium labeled Phaseic acid[1].
|
-
- HY-B1053S
-
|
Iotalamic acid-d3 is the deuterium labeled Iotalamic acid[1].
|
-
- HY-B1899S1
-
|
Taurodeoxycholic acid-d4 is the deuterium labeled Taurodeoxycholic acid[1].
|
-
- HY-W010255AS
-
|
Phenylglyoxylic acid-d5 (sodium) is the deuterium labeled Phenylglyoxylic acid (sodium)[1].
|
-
- HY-W105832S
-
|
Diglycolic acid-d4 is the deuterium labeled Diglycolic acid[1].
|
-
- HY-Y0001S
-
|
Cyclopropanecarboxylic acid-d4 is the deuterium labeled Cyclopropylcarboxylic acid[1].
|
-
- HY-Y1150S2
-
|
Pivalic acid-d9 is the deuterium labeled Pivalic acid[1].
|
-
- HY-B0302AS
-
|
Etidronic acid-d3 (disodium) is the deuterium labeled Etidronic acid disodium[1].
|
-
- HY-12769S
-
|
Mebeverine acid-d5 is the deuterium labeled Mebeverine Acid; Mebeverine Acid is a metabolite of Mebeverine, that is an antispasmodic.
|
-
- HY-12771S1
-
|
O-desmethyl Mebeverine acid-d5 (hydrochloride) is the deuterium labeled O-desmethyl Mebeverine acid.
|
-
- HY-12771S
-
|
O-Desmethyl Mebeverine acid-d5 is the deuterium labeled O-desmethyl Mebeverine acid.
|
-
- HY-121950S
-
|
18-Methyleicosanoic acid-d3 is the deuterium labeled 18-Methyleicosanoic acid.
|
-
- HY-12771S2
-
|
O-Desmethyl Mebeverine acid-d6 is deuterium labeled O-desmethyl Mebeverine acid.
|
-
- HY-N0305S1
-
|
5-Aminolevulinic acid-d2 (hydrochloride) is deuterium labeled 5-Aminolevulinic acid (hydrochloride).
|
-
- HY-139483S
-
|
Epinephrine Sulfonic acid-d3 is the deuterium labeled Epinephrine Sulfonic acid[1].
|
-
- HY-131314S
-
|
Ibuprofen carboxylic acid-d3 is the deuterium labeled Ibuprofen carboxylic acid[1].
|
-
- HY-W141770S
-
|
DL-Phenylmercapturic acid-d2 is the deuterium labeled DL-Phenylmercapturic acid[1].
|
-
- HY-W012738S
-
|
DL-Pyroglutamic acid-d5 is the deuterium labeled DL-Pyroglutamic acid[1].
|
-
- HY-W141770S1
-
|
DL-Phenylmercapturic acid-d5 is the deuterium labeled DL-Phenylmercapturic acid[1].
|
-
- HY-N1481S
-
|
Linoleic Acid-d11 methyl ester is the deuterium labeled Linoleic Acid methyl ester[1].
|
-
- HY-113328S
-
|
Aminoadipic acid-d3 is the deuterium labeled Aminoadipic acid. Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine.
|
-
- HY-W018790S
-
|
4-Dimethylamino benzoic acid-d6 is deuterium labeled 4-Dimethylaminobenzoic acid.
|
-
- HY-W035361S
-
|
(Aminomethyl)phosphonic acid-d2 is the deuterium labeled (Aminomethyl)phosphonic acid[1].
|
-
- HY-W099438S
-
|
n-Butoxyacetic acid-d9 is the deuterium labeled n-Butoxyacetic acid[1].
|
-
- HY-Y0069S1
-
|
N-Acetylglycine-d2 (Aceturic acid-d2; Acetamidoacetic acid-d2) is the deuterated labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
|
-
- HY-109590S1
-
|
Arachidonic acid-d5 is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes.
|
-
- HY-146713S
-
|
(±)-7-Methyl-nonanoic acid-d3 is the deuterium labeled (±)-7-Methyl-nonanoic acid.
|
-
- HY-W012791S1
-
|
2-(Methylamino)acetic acid-d5 (hydrochloride) is the deuterium labeled 2-(Methylamino)acetic acid.
|
-
- HY-W103882S
-
|
2-(Benzhydrylsulfinyl)acetic acid-d5 is deuterium labeled 2-(Benzhydrylsulfinyl)acetic acid.
|
-
- HY-W002071S
-
|
2-Quinoxalinecarboxylic acid-d4 is the deuterium labeled Fmoc-Pro-OH[1].
|
-
- HY-W010590S
-
|
(Rac)-2-Aminobutyric acid-d3 is the deuterium labeled Chlomethoxyfen[1].
|
-
- HY-Y0267S
-
|
Phenoxyacetic acid-d5 is the deuterium labeled Phenoxyacetic acid[1]. Phenoxyacetic acid is an endogenous metabolite.
|
-
- HY-Y1009S
-
|
Methoxyacetic acid-d3 is the deuterium labeled Methoxyacetic acid[1]. Methoxyacetic acid is an endogenous metabolite.
|
-
- HY-W702637
-
|
3-(Trimethylsilyl)propanoic acid-d4 sodium is deuterated labeled 3-(Trimethylsilyl)propanoic acid.
|
-
- HY-113295S3
-
|
Salicyluric acid-d4 is deuterated labeled Salicyluric acid (HY-113295). Salicyluric acid is an endogenous metabolite.
|
-
- HY-107494S2
-
|
4-Oxoretinoic acid-d3 is the deuterium labeled 4-Oxoretinoic acid[1].
|
-
- HY-141749S
-
|
(Rac)-Clopidogrel carboxylic acid-d4 is the deuterium labeled (Rac)-Clopidogrel carboxylic acid[1].
|
-
- HY-B1788S
-
|
Taurocholic acid-d4 (sodium) is the deuterium labeled Taurocholic acid. Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
|
-
- HY-131620S
-
|
4-Methylhippuric acid-d7 is the deuterium labeled 4-Methylhippuric acid[1].
|
-
- HY-124350S
-
|
10-Formylfolic acid-d4 is the deuterium labeled 10-Formylfolic acid[1].
|
-
- HY-133707S1
-
|
β-Muricholic acid-d4 is the deuterium labeled β-Muricholic acid[1].
|
-
- HY-W004283S1
-
|
Pentadecanoic acid-d3 is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.
|
-
- HY-133890AS
-
|
Tauro-α-muricholic acid-d4 (sodium) is the deuterium labeled Tauro-α-muricholic acid sodium[1].
|
-
- HY-B0172S
-
|
Lithocholic acid-d4 is the deuterium labeled Lithocholic acid, which is a toxic secondary bile acid[1].
|
-
- HY-113099S
-
|
Indolelactic acid-d5 is the deuterium labeled Indolelactic acid. Indolelactic acid is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures.
|
-
- HY-W127329S
-
|
12-Hydroxystearic acid-d5 is the deuterium labeled 12-Hydroxystearic acid[1].
|
-
- HY-133707S
-
|
β-Muricholic acid-d5 is the deuterium labeled β-Muricholic acid[1].
|
-
- HY-125138S
-
|
ω-Muricholic Acid-d5 is the deuterium labeled ω-Muricholic Acid[1].
|
-
- HY-W004283S
-
|
Pentadecanoic acid-d29 is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.
|
-
- HY-B1788S1
-
|
Taurocholic acid-d4 is deuterium labeled Taurocholic acid. Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
|
-
- HY-W004283S2
-
|
Pentadecanoic acid-d2 is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.
|
-
- HY-W154267S
-
|
(Rac)-3-Aminoisobutyric acid-d3 (hydrochloride) is the deuterium labeled DL-Histidine[1].
|
-
- HY-Y1315S
-
|
DL-Tartaric acid-d2 is the deuterium labeled DL-Tartaric acid (HY-Y1315)[1].
|
-
- HY-150718S
-
|
α-Ketoisohexanoic acid-d3 (sodium) is the deuterium labeled α-Ketoisohexanoic acid sodium[1].
|
-
- HY-78571S
-
|
3-Methylbenzoic acid-d7 is the deuterium labeled 3-Methylbenzoic acid[1].
|
-
- HY-I0746S
-
|
3-Aminobenzoic acid-d4 is the deuterium labeled 3-Aminobenzoic acid[1].
|
-
- HY-W015333S
-
|
2-Bromobutanoic acid-d6 is the deuterium labeled 2-Bromobutanoic acid[1].
|
-
- HY-W032375S
-
|
3-Mercaptopropionic acid-d4 is the deuterium labeled 3-Mercaptopropionic acid[1].
|
-
- HY-W220946S
-
|
2-Chlorobutanoic acid-d6 is the deuterium labeled 2-Chlorobutanoic acid[1].
|
-
- HY-W245465
-
|
2-Nitrobenzoic acid-d4 is the deuterium labeled 2-Nitrobenzoic acid[1].
|
-
- HY-Y0607S1
-
|
4-Nitrobenzoic acid-d2 is the deuterium labeled 4-Nitrobenzoic acid[1].
|
-
- HY-Y1027S2
-
|
2-Chlorobenzoic acid-d4 is the deuterium labeled 2-Chlorobenzoic acid[1].
|
-
- HY-Y1115S
-
|
2-Fluorobenzoic acid-d4 is the deuterium labeled 2-Fluorobenzoic acid[1].
|
-
- HY-Y1138S
-
|
2-Bromobenzoic acid-d4 is the deuterium labeled 2-Bromobenzoic acid[1].
|
-
- HY-Y1313S
-
|
3-Nitrobenzoic acid-d4 is the deuterium labeled 3-Nitrobenzoic acid[1].
|
-
- HY-B0421S
-
|
Mycophenolic acid-d3 is deuterium labeled Mycophenolic acid, which is an an immunosuppresant agent and has potent anti-proliferative activity.
|
-
- HY-W013049S1
-
|
Docosanoic acid-d43 is the deuterium labeled Docosanoic acid. Docosanoic acid is poorly absorbed, and a cholesterol-raising saturated fatty acid in humans.
|
-
- HY-41912AS
-
|
D-2-Aminohexanoic acid-d9 is the deuterium labeled D-2-Aminohexanoic acid.
|
-
- HY-W012709S
-
|
DL-2-Aminohexanoic acid-d9 is the deuterium labeled DL-2-Aminohexanoic acid.
|
-
- HY-W013049S3
-
|
Docosanoic acid-d3 is the deuterium labeled Docosanoic acid. Docosanoic acid is poorly absorbed, and a cholesterol-raising saturated fatty acid in humans.
|
-
- HY-100560S
-
|
Abscisic acid-d6 is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H+-ATPase)[1].
|
-
- HY-21323S
-
|
Isophthalic-2,4,5,6 Acid-d4 is the deuterium labeled Isophthalic acid[1].
|
-
- HY-W016473S
-
|
Adamantane-carboxylic Acid-d15 is the deuterium labeled Adamantane-1-carboxylic acid[1].
|
-
- HY-113328S1
-
|
Aminoadipic acid-d6 is deuterated labeled Aminoadipic acid (HY-113328). Aminoadipic acid is an intermediate in the metabolism of lysine and glycopurine.
|
-
- HY-B0660S
-
|
Eicosapentaenoic Acid-d5 is the deuterium labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA; Timnodonic acid) is an omega-3 fatty acid.
|
-
- HY-139610S1
-
|
3-Sulfo-glycodeoxycholic acid-d4 (sodium) is the deuterium labeled 3-Sulfo-glycodeoxycholic acid[1].
|
-
- HY-W015924S
-
|
2-Hydroxyisobutyric acid-d6 is the deuterium labeled 2-Hydroxyisobutyric acid. 2-Hydroxyisobutyric acid is an endogenous metabolite.
|
-
- HY-131619S
-
|
3-Methyl Hippuric acid-d7 is the deuterium labeled 3-Methyl Hippuric acid[1].
|
-
- HY-B0515AS1
-
|
Ibandronic acid-d3 is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
|
-
- HY-109590S2
-
|
Arachidonic acid-d11 is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes[1][2].
|
-
- HY-109590S
-
1 Publications Verification
|
Arachidonic acid-d8 is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes[1][2].
|
-
- HY-139924S
-
|
3β-Cholic acid-d4 is the deuterium labeled 3β-Cholic acid[1].
|
-
- HY-W012583S
-
|
2,2'-Thiodiacetic acid-d4 is the deuterium labeled 2,2'-Thiodiacetic acid[1].
|
-
- HY-W013049S4
-
|
Docosanoic acid-d4-11 is the deuterium labeled Docosanoic acid. Docosanoic acid is poorly absorbed, and a cholesterol-raising saturated fatty acid in humans.
|
-
- HY-113524S
-
|
N-Acetyl-L-aspartic acid-d3 is the deuterium labeled N-Acetyl-L-aspartic acid. N-Acetyl-L-aspartic acid is a derivative of aspartic acid.
|
-
- HY-W012791S
-
|
2-(Methylamino)acetic acid-d3 (hydrochloride) is the deuterium labeled 2-(Methylamino)acetic acid[1].
|
-
- HY-W013049S5
-
|
Docosanoic acid-d4-2 is the deuterium labeled Docosanoic acid. Docosanoic acid is poorly absorbed, and a cholesterol-raising saturated fatty acid in humans.
|
-
- HY-113482S
-
|
1β-Hydroxydeoxycholic Acid-d5 is the deuterium labeled 1β-Hydroxydeoxycholic Acid[1].
|
-
- HY-W014633S
-
|
4-(Trifluoromethoxy)benzoic acid-d4 is the deuterium labeled 4-(Trifluoromethoxy)benzoic acid[1].
|
-
- HY-143860S
-
|
C14 Benzalkonium chloride -1 acid-d5 is the deuterium labeled C14 Benzalkonium chloride -1 acid[1].
|
-
- HY-150664S
-
|
4-Methoxy-benzoic acid-d3 is the deuterium labeled 4-Methoxy-benzoic acid[1].
|
-
- HY-41463S
-
|
4-(Butylamino)benzoic acid-d7 is the deuterium labeled 4-(Butylamino)benzoic acid[1].
|
-
- HY-75968S
-
|
2,6-Difluorobenzoic acid-d3 is the deuterium labeled 2,6-Difluorobenzoic acid[1].
|
-
- HY-N0216BS
-
|
Benzoic-3,5 Acid-d2 is the deuterium labeled Benzoic-3,5 Acid[1].
|
-
- HY-W012507S
-
|
2,6-Dichlorobenzoic acid-d3 is the deuterium labeled 2,6-Dichlorobenzoic acid[1].
|
-
- HY-W012510S
-
|
2,4-Dichlorobenzoic acid-d3 is the deuterium labeled 2,4-Dichlorobenzoic acid[1].
|
-
- HY-W015139S
-
|
3,4-Dichlorobenzoic acid-d3 is the deuterium labeled 3,4-Dichlorobenzoic acid[1].
|
-
- HY-W015496S
-
|
3,5-Difluorobenzoic acid-d3 is the deuterium labeled 3,5-Difluorobenzoic acid[1].
|
-
- HY-W015881S
-
|
2,2-Dimethylbutanoic acid-d11 is the deuterium labeled 2,2-Dimethylbutanoic acid[1].
|
-
- HY-W018728S
-
|
3,5-Dimethylbenzoic acid-d9 is the deuterium labeled 3,5-Dimethylbenzoic acid[1].
|
-
- HY-W039173S
-
|
4-(Methylamino)butanoic acid-d9 hydrochloride is the deuterium labeled 4-(Methylamino)butanoic acid hydrochloride[1].
|
-
- HY-W091636S
-
|
3,3'-Azanediyldipropionic acid-d8 is the deuterium labeled 3,3'-Azanediyldipropionic acid[1].
|
-
- HY-Y0957S
-
|
2,5-Difluorobenzoic acid-d3 is the deuterium labeled 2,5-Difluorobenzoic acid[1].
|
-
- HY-W002068S
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2,4-Difluorobenzoic acid-d3 is the deuterium labeled 2,4-Difluorobenzoic acid[1].
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-
- HY-W710495
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N-Acetyl-L-aspartic acid-d3-1is the deuterium labeledN-Acetyl-L-aspartic acid(HY-W710495) .
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-
- HY-B0760S
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Fenofibric acid-d6 (FNF acid-d6) is the deuterium labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
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-
- HY-139610S
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|
3-Sulfo-glycodeoxycholic acid-d4 (disodium) is the deuterium labeled 3-Sulfo-glycodeoxycholic acid disodium[1].
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-
- HY-W015967S
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Glycolic acid-d2 is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
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-
- HY-113353S
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Nicotinuric acid-d4 is the deuterium labeled Nicotinuric acid. Nicotinuric acid is an acyl glycine. Nicotinuric acid is a metabolite of nicotinic acid[1][2].
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- HY-113308AS
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Taurolithocholic acid-d4 (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].
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-
- HY-W011713S
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|
N-(4-Aminobenzoyl)-L-glutamic acid-d4 is the deuterium labeled 4-Nitrobenzoic acid[1].
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-
- HY-Y1176S
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Isonipecotic acid-d9 is the deuterium labeled Isonipecotic acid[1]. Isonipecotic acid is a GABAA receptor partial agonist[2].
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-
- HY-76847S
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Chenodeoxycholic Acid-d4 is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
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-
- HY-N0420S
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Succinic acid-d6 is the deuterium labeled Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.
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- HY-113308AS1
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Taurolithocholic Acid-d5 (sodium) is the deuterium labeled Taurolithocholic acid sodium salt. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1][2].
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- HY-76847S1
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Chenodeoxycholic Acid-d9 is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
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-
- HY-113327S
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1,3,7-Trimethyluric acid-d9 is the deuterium labeled 1,3,7-Trimethyluric acid[1].
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- HY-W011873S
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Palmitoleic acid-d14 is the deuterium labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.
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- HY-100805S
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D-Glutamic acid-d5 is the deuterium labeled D-Glutamic acid. D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods[1].
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- HY-W011873S1
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Palmitoleic acid-d13 is the deuterium labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.
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- HY-76847S3
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Chenodeoxycholic acid-d5 is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
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- HY-113308AS2
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Taurolithocholic acid-d4-1 (sodium) is the deuterium labeled Taurolithocholic acid. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].
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- HY-B2219S8
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Stearic acid-d is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-W001942S1
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DL-2-Methylbutyric acid-d9 is the deuterium labeled DL-2-Methylbutyric acid[1].
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- HY-W001955S
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2-(4-Fluorophenyl)acetic acid-d2 is the deuterium labeled 2-(4-Fluorophenyl)acetic acid[1].
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- HY-W007872S
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2,2'-(Methylazanediyl)diacetic acid-d4 is the deuterium labeled 2,2'-(Methylazanediyl)diacetic acid[1].
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-
- HY-W017763S
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|
Tetrahydrofuran-2-carboxylic acid-d7 is the deuterium labeled Tetrahydrofuran-2-carboxylic acid[1].
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- HY-W131158S
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2-(2-Ethoxyphenoxy)acetic acid-d5 is the deuterium labeled 2-(2-Ethoxyphenoxy)acetic acid[1].
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-
- HY-W282887S
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2-(4-Nonylphenoxy)acetic acid-d2 is the deuterium labeled 2-(4-Nonylphenoxy)acetic acid[1].
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- HY-Y0001S1
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Cyclopropane-1-carboxylic Acid-d1 is the deuterium labeled Cyclopropane-1-carboxylic Acid[1].
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- HY-Y0839S
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Levulinic acid-d5 is the deuterium labeled Levulinic acid[1]. Levulinic acid is a precursor for the synthesis of biofuels, such as ethyl levulinate[2].
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- HY-Y1373S
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Cyclohexanecarboxylic acid-d1 is the deuterium labeled Cyclohexanecarboxylic acid[1]. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action[2].
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- HY-Y1373S1
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Cyclohexanecarboxylic acid-d11 is the deuterium labeled Cyclohexanecarboxylic acid[1]. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action[2].
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- HY-161008S
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Heroin-CH2-acid-d6 (compound 4) is a deuterated heroin hapten that can be used in the development of heroin vaccines .
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- HY-W028943S
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(E)-3-Methyl-2-hexenoic acid-d5 ((2E)-3-Methyl-2-hexenoic acid-d5) is a deuterium labeled (E)-3-Methyl-2-hexenoic acid. (E)-3-Methyl-2-hexenoic acid is an axillary odor-related compound .
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- HY-B0515AS
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Ibandronic Acid-d3 (sodium) is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis[1][2].
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- HY-W012980S
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Isovaleric acid-d9 is the deuterium labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human.
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- HY-34740S
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Ethylmalonic acid-d3 is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.
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- HY-103395S
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Methylmalonic acid-d3 is the deuterium labeled Methylmalonic acid. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer[1][2].
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- HY-B0149S
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Tranexamic acid-d2 is the deuterium labeled Tranexamic acid. Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments.
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- HY-34740S1
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Ethylmalonic acid-d5 is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.
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- HY-113411S
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3-Hydroxyglutaric acid-d5 is the deuterium labeled 3-Hydroxyglutaric acid. 3-Hydroxyglutaric acid is a glutaric acid derivative[1][2].
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- HY-70002BS
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Enzalutamide carboxylic acid-d6 is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide[1].
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- HY-N0666S2
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DL-Aspartic acid-d3 is the deuterium labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
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- HY-N0666S8
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L-Aspartic acid-d3 is the deuterium labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
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- HY-W206016S
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3-Amino-2-hydroxybenzoic acid-d3 is deuterium labeled 3-Amino-2-hydroxybenzoic acid.
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- HY-N1446S5
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Oleic acid-d9 is deuterium labeled Oleic acid. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator[1][2].
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- HY-W016456S
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5-Bromopentanoic-3,3,4,4 Acid-d4 is the deuterium labeled 5-Bromopentanoic acid[1].
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- HY-B0148S
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Risedronic Acid-d4 is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption[1][2].
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- HY-N1428S
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Citric acid-d4 is the deuterium labeled Citric acid. Citric acid is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a natural preservative and food tartness enhancer.
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- HY-W013826S
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4-(N-(Butylcarbamoyl)sulfamoyl)benzoic acid-d6 is the deuterium labeled 4-(N-(Butylcarbamoyl)sulfamoyl)benzoic acid[1].
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- HY-B1008S
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4-Aminobenzoic acid-d4 is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.
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- HY-W013826S1
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4-(N-(Butylcarbamoyl)sulfamoyl)benzoic acid-d9 is the deuterium labeled 4-(N-(Butylcarbamoyl)sulfamoyl)benzoic acid[1].
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- HY-W010098S
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Terephthalic acid-d4 is the deuterium labeled Terephthalic acid. Terephthalic acid is one isomer of the three phthalic, a precursor to the polyester PET, used to make clothing and plastic bottles.
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- HY-B2219S3
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Stearic acid-d3 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-116752S
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Dinor-12-oxo phytodienoic acid-d5 is the deuterium labeled Dinor-12-oxo phytodienoic acid[1].
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- HY-B2219S1
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Stearic acid-d2 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-106579S
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Tiaprofenic acid-d3 is a deuterium labeled Tiaprofenic acid. Tiaprofenic acid is a nonsteroidal anti-inflammatory agent (NSAID) mainly used in the treatment of rheumatic diseases[1].
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- HY-B2219S4
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Stearic Acid-d35 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-125140S
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ω-3 Arachidonic Acid-d8 is the deuterium labeled ω-3 Arachidonic Acid[1].
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- HY-B2219S6
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Stearic acid-d55 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-113301S1
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Hexacosanoic acid-d4-11 is the deuterium labeled Hexacosanoic acid. Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis.
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- HY-B2219S9
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Stearic acid-d7 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-W002094S
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Cyclopropane-1,1-dicarboxylic acid-d4 is the deuterium labeled Cyclopropane-1,1-dicarboxylic acid[1].
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- HY-W040287S
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4-(2,4-Dichlorophenoxy)butanoic acid-d3 is the deuterium labeled 4-(2,4-Dichlorophenoxy)butanoic acid[1].
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- HY-W056964S
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Naphthalene-2,6-dicarboxylic acid-d6 is the deuterium labeled Naphthalene-2,6-dicarboxylic acid[1].
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- HY-W188178S
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2-[Methyl(nitroso)amino]acetic acid-d3 is the deuterium labeled 2-[methyl(nitroso)amino]acetic acid[1].
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- HY-Y1088S1
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Hydrocinnamic acid-d2 is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities[2].
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- HY-Y1088S3
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Hydrocinnamic acid-d5 is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities[2].
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- HY-Y1139S
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Pimelic acid-d4 is the deuterium labeled Pimelic acid[1]. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.
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- HY-157568S
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Budesonide acid-d8 is a deuterium labeled Budesonide acid. Budesonide acid is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist .
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- HY-Y0262S
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Oxalic Acid-d2 is the deuterium labeled Oxalic Acid. Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
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- HY-126061S
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1,7-Dimethyluric acid-d3 is the deuterium labeled 1,7-Dimethyluric acid. 1,7-Dimethyluric acid is the metabolite of caffeine[1].
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- HY-W001080S
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3,4-Dihydroxybenzeneacetic acid-d5 is the deuterium labeled 3,4-Dihydroxybenzeneacetic acid. 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.
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- HY-W015882S
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4-Methylpentanoic acid-d12 is the deuterium labeled 4-Methylpentanoic acid. 4-Methylpentanoic acid (Isocaproic Acid) is a Short chain fatty acid (SCFA)[1].
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- HY-W016825S1
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2-(Pyridin-2-yl)acetic acid-d4 (hydrochloride) is deuterium labeled 2-(Pyridin-2-yl)acetic acid hydrochloride.
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- HY-133972S
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3β-Hydroxy-5-cholestenoic acid-d5 is deuterium labeled 3β-Hydroxy-5-cholestenoic acid.
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- HY-113220S
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Monoisobutyl phthalic acid-d4 is the deuterium labeled Monoisobutyl phthalic acid[1]. Monoisobutyl phthalic acid is a phthalate metabolite that is in human semen and in meconium[2].
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- HY-N0339S
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Syringic acid-d6 is the deuterium labeled Syringic acid[1]. Syringic acid is correlated with high antioxidant activity and inhibition of LDL oxidation[2][3].
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- HY-Y0367S
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Maleic Acid-d2 is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].
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- HY-N0156S
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Oleanolic acid-d3 is the deuterium labeled Oleanolic Acid[1]. Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities[2].
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- HY-N0324S
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Cholic acid-d4 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
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- HY-141721S
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2-(((7-Methyloctyl)oxy)carbonyl)benzoic acid-d4 is the deuterium labeled 2-(((7-Methyloctyl)oxy)carbonyl)benzoic acid[1].
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- HY-W009973S
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4-Anilino-4-oxobutanoic acid-d5 is the deuterium labeled 4-Anilino-4-oxobutanoic acid[1].
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- HY-N0324S1
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Cholic acid-d5 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
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- HY-132800S
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7-Methyl-3-methyluric acid-d3 is the deuterium labeled 7-Methyl-3-methyluric acid[1].
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- HY-115433S1
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α-Muricholic acid-d4 is the deuterium labeled α-Muricholic acid. α-Muricholic acid is the most abundant primary bile acid in rodents[1][2].
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- HY-125774S
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Bimatoprost acid-d4 (17-Phenyl trinor PGF2α-d4) is the deuterium labeled Bimatoprost acid[1].
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- HY-135400S
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Glyco-obeticholic acid-d5 is the deuterium labeled Glyco-Obeticholic acid. Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist[1].
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- HY-115433S
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α-Muricholic acid-d5 is the deuterium labeled α-Muricholic acid. α-Muricholic acid is the most abundant primary bile acid in rodents[1][2].
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- HY-135399S
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Tauro-obeticholic acid-d5 sodium is deuterium labeled Tauro-obeticholic acid. Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist.
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- HY-B2219S7
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Stearic acid-d4 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils[1].
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- HY-N2041S5
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Myristic acid-d is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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-
- HY-W016342S
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2-Amino-4-sulfobutanoic acid-d4 is the deuterium labeled 2-Amino-4-sulfobutanoic acid[1].
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-
- HY-W143303S
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3-Hydroxy-3-methylvaleric acid-d5 is the deuterium labeled 3-Hydroxy-3-methylvaleric Acid[1].
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-
- HY-142907S
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|
(2-Fluoro-4-biphenyl)acetic acid-d5 is the deuterium labeled (2-Fluoro-4-biphenyl)acetic acid .
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-
- HY-78985S
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|
Benzene-1,3,5-tricarboxylic acid-d3 is the deuterium labeled Benzene-1,3,5-tricarboxylic acid[1].
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- HY-B0541S
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Cyclamic Acid-d11 is the deuterium labeled Cyclamic acid[1]. Cyclamic acid (Cyclohexylsulfamic acid) is one of the most widely used artificial sweetenersin food and pharmaceuticals[2].
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- HY-W012241S
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Dodecanedioic acid-d20 is the deuterium labeled Dodecanedioic acid[1]. Dodecanedioic acid (C12) is a dicarboxylic acid with a metabolic pathway intermediate to those of lipids and carbohydrates[2].
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- HY-W012241S1
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Dodecanedioic acid-d4 is the deuterium labeled Dodecanedioic acid[1]. Dodecanedioic acid (C12) is a dicarboxylic acid with a metabolic pathway intermediate to those of lipids and carbohydrates[2].
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-
- HY-W015883S3
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Fumaric acid-d2 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
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- HY-W015883S4
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Fumaric acid-d4 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
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- HY-Y1088S2
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Hydrocinnamic acid-d9 is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activitie[2]s.
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- HY-N1423S1
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Glycocholic acid-d5 is the deuterium labeled Glycocholic acid. Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways .
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- HY-18569S1
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3-Indoleacetic acid-d4 (Indole-3-acetic acid-d4; 3-IAA-d4)is the deuterium labeled3-Indoleacetic acid(HY-18569) . 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
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-
- HY-W015060S1
-
|
2-(2-Methylbenzamido)acetic acid-d2 is the deuterium labeled 2-(2-Methylbenzamido)acetic acid. 2-(2-Methylbenzamido)acetic acid is a metabolite detected in urine.
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-
- HY-W015229S
-
|
3-Indolepropionic acid-d2 is the deuterium labeled 3-Indolepropionic acid. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.
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-
- HY-N1423S
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|
Glycocholic acid-d4 is the deuterium labeled Glycocholic acid. Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].
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-
- HY-W015060S
-
|
2-(2-Methylbenzamido)acetic acid-d7 is the deuterium labeled 2-(2-Methylbenzamido)acetic acid. 2-(2-Methylbenzamido)acetic acid is a metabolite detected in urine.
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-
- HY-N2341S
-
|
Palmitelaidic acid-d13 is the deuterium labeled Palmitelaidic Acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
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-
- HY-113455S
-
|
9S-HODE-d4 (Alpha-dimorphecolic acid-d4) is the deuterium labeled 9S-HODE (HY-113455) .
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-
- HY-76082S
-
|
L-Pyroglutamic acid-d5 is the deuterium labeled L-Pyroglutamic acid. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
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-
- HY-N9933S
-
|
Tauro-β-muricholic acid-d4-1 (T-βMCA-d4-1) sodiumis the deuterium labeledTauro-β-muricholic acid(HY-N9933) .
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-
- HY-Y1311S
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Malic acid-d3 is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods[1][2].
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- HY-N0384S2
-
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Homovanillic acid-d5 is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
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-
- HY-N0384S
-
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Homovanillic acid-d3 is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
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-
- HY-16637S1
-
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Folic acid-d4 is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
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-
- HY-W013425S
-
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2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 is the deuterium labeled 2-Hydroxy-5-(phenyldiazenyl)benzoic acid[1].
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- HY-N0384S1
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Homovanillic acid-d2 is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
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- HY-N1424S
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Glycoursodeoxycholic acid-d4 (Ursodeoxycholylglycine-d4) is the deuterium labeled Glycoursodeoxycholic acid. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid[1][2].
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- HY-145003S
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4(Z),7(Z)-Decadienoic acid-d5 is the deuterium labeled 4(Z),7(Z)-Decadienoic acid[1].
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- HY-41417S1
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Octanoic acid-d3 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
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- HY-41417S2
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Octanoic acid-d2 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
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- HY-41417S
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Octanoic acid-d15 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
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- HY-N2041S3
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Myristic acid-d33 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S
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1 Publications Verification
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Myristic acid-d27 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-B0172AS
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Isoallolithocholic acid-d2 is the deuterium labeled Isoallolithocholic acid (HY-B0172A). Isoallolithocholic acid is a T cell regulator and enhances regulatory T cells (Tregs) differentiation[1][2].
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- HY-N2041S1
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Myristic acid-d2 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S6
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Myristic acid-d5 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S7
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Myristic acid-d7 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-W004261S
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Nonadecanoic acid-d37 is the deuterium labeled Nonadecanoic acid. Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis to defence[1].
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- HY-Y0127S
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D(-)-2-Aminobutyric acid-d6 is the deuterium labeled D(-)-2-Aminobutyric acid. D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.
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- HY-143854S
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N-Nitroso-N-methyl-4-aminobutyric acid-d3 is the deuterium labeled N-Nitroso-N-methyl-4-aminobutyric acid[1].
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- HY-148677S
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2,3-Dihydroxy-2-methylbutanoic acid-d3 is the deuterium labeled 2,3-Dihydroxy-2-methylbutanoic acid[1].
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- HY-113301S
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Hexacosanoic acid-d4 is the deuterium labeled Hexacosanoic acid[1]. Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis[2].
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- HY-W012980S2
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Isovaleric acid-d2 is the deuterium labeled Isovaleric acid[1]. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human[2].
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- HY-W012980S3
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Isovaleric acid-d7 is the deuterium labeled Isovaleric acid[1]. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human[2].
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- HY-W014666S
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Xanthurenic acid-d4 is the deuterium labeled Xanthurenic acid[1]. Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus[2].
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- HY-W015300S
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Suberic acid-d4 is the deuterium labeled Suberic acid[1]. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency[2].
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- HY-W015300S1
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Suberic acid-d12 is the deuterium labeled Suberic acid[1]. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency[2].
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- HY-W015882S1
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4-Methylpentanoic acid-d11 is the deuterium labeled 4-Methylpentanoic acid[1]. 4-Methylpentanoic acid (Isocaproic Acid) is a Short chain fatty acid (SCFA)[2].
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- HY-W016825S
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2-(Pyridin-2-yl)acetic acid-d6 (hydrochloride) is the deuterium labeled 2-(Pyridin-2-yl)acetic acid hydrochloride[1].
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- HY-W016825S2
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2-(Pyridin-2-yl)acetic acid-d2 (hydrochloride) is the deuterium labeled 2-(Pyridin-2-yl)acetic acid hydrochloride[1].
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- HY-W030778S
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Nitrilotriacetic acid-d9 is the deuterium labeled Nitrilotriacetic acid[1]. Nitrilotriacetic acid is an aminotricarboxylic acid. Nitrilotriacetic acid can be used as a chelating agent, forming coordination compounds with metal ions[2].
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- HY-W087940S
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Benzene-1,2,4,5-tetracarboxylic acid-d6 is the deuterium labeled Benzene-1,2,4,5-tetracarboxylic acid[1].
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- HY-N0593S1
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Deoxycholic acid-d5 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
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- HY-W016562S1
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Hippuric acid-d2 is the deuterium labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
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- HY-113493S1
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4-Pyridoxic acid-d3 is the deuterium labeled 4-Pyridoxic acid. 4-Pyridoxic acid is a catabolic product of vitamin B6 which is excreted in the urine[1][2].
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- HY-N0593S2
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Deoxycholic acid-d6 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
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- HY-W016562S
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Hippuric acid-d5 is the deuterium labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
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- HY-N0610AS
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Cinnamic acid-d6 is the deuterium labeled Cinnamic acid. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.
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- HY-B0167S
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Salicylic acid-d6 is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].
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- HY-N1446S3
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Oleic acid-d17 is the deuterium labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].
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- HY-N0593S
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Deoxycholic acid-d4 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
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- HY-N1446S1
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Oleic acid-d2) is the deuterium labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].
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- HY-75087S
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(R)-Pyrrolidine-2-carboxylic acid-d3 is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.
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- HY-W004282S
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Undecanoic acid-d21 is the deuterium labeled Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum[1].
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- HY-W004282S1
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Undecanoic acid-d3 is the deuterium labeled Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum[1].
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- HY-W004282S2
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Undecanoic acid-d2 is the deuterium labeled Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum[1].
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- HY-12357S2
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Bempedoic acid-d4 is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].
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- HY-B0704S
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Azelaic acid-d14 is the deuterium labeled Azelaic acid[1]. Azelaic acid is an organic compound produced by the ozonolysis of oleic acid;component of a number of hair and skin conditioners[2][3].
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- HY-W002011S
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Quinoline-2-carboxylic acid-d6 is the deuterium labeled Quinoline-2-carboxylic acid[1]. Quinoline-2-carboxylic acid is an endogenous metabolite.
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- HY-W015175S
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p-Toluenesulfonic acid-d7 (monohydrate) is the deuterium labeled p-Toluenesulfonic acid monohydrate[1]. p-Toluenesulfonic acid monohydrate, a strong organic acid, acts as organic catalyst used in organic synthesis[2][3].
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- HY-B1306S
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4-Aminohippuric acid-d4 is the deuterium labeled 4-Aminohippuric acid. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow.
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- HY-108398AS
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Mead acid-d6 is the deuterium labeled Mead acid. Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency[1].
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- HY-101541S
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Docosahexaenoic acid-d5 methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed[1][2].
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- HY-N1394S1
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p-Anisic acid-d4 is the deuterium labeled p-Anisic acid[1]. p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties[2].
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- HY-W280618S
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4-(4-Chloro-2-methylphenoxy)butanoic acid-d3 is the deuterium labeled 4-(4-Chloro-2-methylphenoxy)butanoic acid[1].
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- HY-Y0771S
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3,4-Dimethoxyphenylacetic acid-d2 is the deuterium labeled 3,4-Dimethoxyphenylacetic acid[1]. 3,4-Dimethoxyphenylacetic acid is a building block in the chemical synthesis[2].
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- HY-B0493S
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Niflumic Acid-d5 is the deuterium labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis[1][2].
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- HY-A0281S
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4-Phenylbutyric acid-d11 is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
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- HY-W015309S
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Decanoic acid-d3 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects[1][2][3].
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- HY-N0169S
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Hyodeoxycholic acid-d5 is the deuterium labeled Hyodeoxycholic acid. Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
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- HY-B2167S
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Docosahexaenoic acid-d5 is the deuterium labeled Docosahexaenoic Acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
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- HY-W015309S2
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Decanoic acid-d2 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects[1][2][3].
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- HY-W015309S1
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Decanoic acid-d199 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects[1][2][3].
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- HY-W014663S
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(S)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid-d3 is the deuterium labeled (S)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid.
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- HY-W015309S3
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Decanoic acid-d5 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects[1][2][3].
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- HY-N0351S1
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p-Coumaric acid-d6 is the deuterium labeled p-Coumaric acid (HY-N0351). p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities[1][2].
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- HY-41417S6
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Octanoic acid-d5 is the deuterium labeled Octanoic acid[1]. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
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- HY-W014787S
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Decanedioic acid-d4 is the deuterium labeled Decanedioic acid[1]. Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[2].
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- HY-W014787S1
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Decanedioic acid-d16 is the deuterium labeled Decanedioic acid[1]. Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[2].
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- HY-122464S2
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(±)-Jasmonic acid-d5 is the deuterium labeled (±)-Jasmonic acid. (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.
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- HY-122464S1
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Jasmonic acid-d5 is deuterium labeled (±)-Jasmonic acid. (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.
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- HY-30004S
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1-Aminocyclopropane-1-carboxylic acid-d4 is the deuterium labeled 1-Aminocyclopropane-1-carboxylic acid. Aminocyclopropane-1-carboxylic acid is an endogenous metabolite[1].
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- HY-Y0669S
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Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid, a metabolite of Lysine, is an important precursor of many useful microbial secondary metabolites. Pipecolic acid can be used as a diagnostic marker of Pyridoxine-dependent epilepsy[1][2].
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- HY-113247S1
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trans-trans-Muconic acid-d4-1 is a deuterium labeled trans-trans-Muconic acid (HY-113247). trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.
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- HY-W393970S1
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2′-Deoxyguanosine 5′-monophosphate-d12 (5'-Deoxyguanylic acid-d12) dilithium is deuterium labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
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- HY-101411S
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4-Acetamidobutanoic acid-d3 is the deuterated analog of 4-Acetamidobutanoic acid (HY-101411). 4-Acetamidobutanoic acid (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities .
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- HY-W018161S
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Hexadecanedioic acid-d28 is the deuterium labeled Hexadecanedioic acid. Hexadecanedioic acid is covalently linked to Sepharose 4B, shows better performance in terms of specificity than dye-based resins and could be used for depletion of SA from plasma samples.
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- HY-W008820S
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Glutaric acid-d6 is the deuterium labeled Glutaric acid. Glutaric acid is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
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- HY-Y0264S1
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4-Hydroxybenzoic acid-d4 is the deuterium labeled 4-Hydroxybenzoic acid. 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.
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- HY-Y0366S3
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Lauric acid-d33 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
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- HY-Y0366S1
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Lauric acid-d233 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
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- HY-101108S
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Tazarotenic acid-d6 is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .
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- HY-N0180S
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18β-Glycyrrhetinic acid-d3 is deuterium labeled 18β-Glycyrrhetinic acid. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
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- HY-Y0366S2
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Lauric acid-d2 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
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- HY-Y0366S5
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Lauric acid-d5 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
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- HY-113019S
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3β,7α-Dihydroxycholest-5-enoic acid-d3 is deuterium labeled 3β,7α-Dihydroxycholest-5-enoic acid.
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- HY-146773S
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7α-Hydroxy-3-oxocholest-4-enoic acid-d3 is deuterium labeled 7α-Hydroxy-3-oxocholest-4-enoic acid.
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- HY-146793S
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3β-Hydroxy-7-oxocholest-5-enoic acid-d3 is deuterium labeled 3β-Hydroxy-7-oxocholest-5-enoic acid.
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- HY-113247S
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trans-trans-Muconic acid-d4 is the deuterium labeled trans-trans-Muconic acid[1]. trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human[2].
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- HY-12357S
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Bempedoic acid-d5 is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].
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- HY-41494S
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O-Toluic acid-d7 is the deuterium labeled o-Toluic acid[1]. o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.
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- HY-76547S
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p-Toluic acid-d4 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
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- HY-76547S1
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p-Toluic acid-d7 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
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- HY-76547S2
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p-Toluic acid-d3 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
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- HY-B0149S1
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Tranexamic acid-d2-1 is the deuterium labeled Tranexamic acid[1]. Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM[2][3].
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- HY-W004515S
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3-Pyridylacetic acid-d4 (hydrochloride) is the deuterium labeled 3-Pyridylacetic acid hydrochloride[1]. 3-Pyridineacetic acid hydrochloride is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids)[2][3].
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- HY-N1429S
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Taurochenodeoxycholic acid-d9 (sodium) is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
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- HY-141745S
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2-(((4-Methyl-7-oxooctyl)oxy)carbonyl)benzoic acid-d4 is the deuterium labeled 2-(((4-Methyl-7-oxooctyl)oxy)carbonyl)benzoic acid[1].
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- HY-N2334AS
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Glycochenodeoxycholic acid-d7 (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].
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- HY-N1429S1
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Taurochenodeoxycholic acid-d5 (sodium) is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
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- HY-N2334S
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Glycochenodeoxycholic acid-d4 is the deuterium labeled Glycochenodeoxycholic acid. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis[1][2].
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- HY-N2027S
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Taurochenodeoxycholic acid-d4 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
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- HY-113427AS
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cis-Vaccenic acid-d13 is the deuterium labeled cis-Vaccenic acid. cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].
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-
- HY-A0281S3
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4-Phenylbutyric acid-d2 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
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-
- HY-W010381S
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2-Methylsuccinic acid-d6 is the deuterium labeled 2-Methylsuccinic acid[1]. 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy[2][3].
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- HY-113121S1
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Vanillylmandelic acid-d is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].
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-
- HY-Y1069S
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(S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive[1][2].
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-
- HY-B1415S
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Clofibric acid-d4 is the deuterium labeled Clofibric acid. Clofibric acid (Chlorofibrinic acid), the pharmaceutically active metabolite of lipid regulators Clofibrate, Etofibrate and Etofyllinclofibrate, is a PPARα agonist which exhibits hypolipidemic effects. Clofibric acid also is an herbicide[1][2][3].
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-
- HY-N1902S
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4-Hydroxyphenylacetic acid-d6 is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].
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- HY-N1429S2
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Taurochenodeoxycholic acid-d4-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
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- HY-W015240S
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N-Acetyl-L-glutamic acid-d5 is the deuterium labeled N-Acetyl-L-glutamic acid. N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human[1].
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- HY-N0216S
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Benzoic acid-d5 is a deuterium substitute for Benzoic acid. Benzoic acid is an aromatic alcohol that occurs naturally in many plants and is a common additive in food, beverages, cosmetics and other products. Benzoic acid can act as a preservative by inhibiting bacteria and fungi[1][2].
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- HY-B1619S
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Cromoglicic acid-d5 is the deuterium labeled Cromolyn[1]. Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis[2].
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-
- HY-N0610S
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trans-Cinnamic acid-d5 is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].
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-
- HY-N0610S1
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trans-Cinnamic acid-d7 is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].
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- HY-W009713S
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(3,4,5-Trimethoxyphenyl)acetic-2,2 Acid-d2 is the deuterium labeled 3,4,5-Trimethoxyphenylacetic acid[1]. 3,4,5-Trimethoxyphenylacetic acid is a metabolite of Mescaline[2].
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- HY-W008820S1
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Glutaric acid-d4 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
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-
- HY-113378S
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3-Hydroxybutyric acid-d4 (sodium) is the deuterium labeled 3-Hydroxybutyric acid. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids[1].
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- HY-W008820S2
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Glutaric acid-d2 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
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- HY-16637S
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Folic acid-d2 (Vitamin B9-d2) is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
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-
- HY-I0508S
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Phthalic acid-d4 is the deuterium labeled Phthalic acid. Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers[1].
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-
- HY-B0631S
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Alendronic acid-d6 is the deuterium labeled Alendronic acid. Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease[1].
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- HY-W004260S1
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Arachidic acid-d39 is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].
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-
- HY-W004260S
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Arachidic acid-d2 is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].
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-
- HY-W004284S
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Heptadecanoic acid-d3 is the deuterium labeled Heptadecanoic acid. Heptadecanoic acid is an odd chain saturated fatty acid (OCS-FA). Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis[1].
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-
- HY-13318S
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Oseltamivir acid-d3 is a deuterium labeled Oseltamivir acid. Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses[1][2].
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- HY-116374S
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Glycolithocholic acid-d4 is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].
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- HY-135103S
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Tauro-β-muricholic acid-d4 (sodium) is the deuterium labeled Tauro-β-muricholic acid sodium. Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3].
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- HY-W004260S2
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Arachidic acid-d3) is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].
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-
- HY-W004284S1
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Heptadecanoic acid-d33 is the deuterium labeled Heptadecanoic acid. Heptadecanoic acid is an odd chain saturated fatty acid (OCS-FA). Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis[1].
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- HY-W041895S
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DL-Glutamic acid-d5 is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability[1].
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- HY-W041895S1
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DL-Glutamic acid-d3 is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability[1].
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- HY-W004260S4
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Arachidic acid-d4 is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].
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- HY-W000793S
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5-Methoxy-1H-indole-3-carboxylic acid-d3 is the deuterium labeled 5-methoxy-1H-indole-3-carboxylic acid[1].
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-
- HY-13777S
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Zoledronic acid-d5 is deuterated labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .
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- HY-113121S
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Vanillylmandelic acid-d3 is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].
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- HY-12222S
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Obeticholic acid-d5 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].
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- HY-15027S
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5-Aminosalicylic Acid-d3 (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
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- HY-12222S1
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Obeticholic Acid-d4 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].
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-
- HY-13936S
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2-(1-Methyl-1H-imidazol-4-yl)acetic acid-d3 is deuterium labeled 2-(1-Methyl-1H-imidazol-4-yl)acetic acid.
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- HY-D0869S
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3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 is the deuterium labeled CAPS[1]. CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis[2][3].
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- HY-Y0084S
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3,4,5-Trimethoxybenzoic acid-d3 is the deuterium labeled 3,4,5-Trimethoxybenzoic acid[1]. 3,4,5-Trimethoxybenzoic acid (Eudesmic acid;Trimethylgallic Acid) is a benzoic acid derivative. A building block in medicine and organic synthesis.
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- HY-W009216S3
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2'-Deoxycytidine-5'-monophosphoric acid-d12 dilithium is deuterium labeled 2'-Deoxycytidine-5'-monophosphoric acid (HY-W009216). 2'-Deoxycytidine-5'-monophosphoric acid is an endogenous metabolite.
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- HY-14608S7
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L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
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-
- HY-14608S8
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L-Glutamic acid-d3 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
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- HY-A0281S2
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4-Phenylbutyric acid-d5 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[2][3][4].
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-
- HY-N1902S1
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4-Hydroxyphenylacetic acid-d4 is the deuterium labeled 4-Hydroxyphenylacetic acid[1]. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[2].
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- HY-W015240S1
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N-Acetyl-L-glutamic acid-d4 is the deuterium labeled N-Acetyl-L-glutamic acid[1]. N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human[2].
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- HY-W014993S1
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1,3-Dimethyluric acid-d3 is deuterated labeled 1,3-Dimethyluric acid (HY-W014993). 1,3-Dimethyluric acid is a product of theophylline metabolism in man. 1,3-Dimethyluric acid is one of the purine components in urinary calculi.
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- HY-100806S
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Kynurenic acid-d5 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8[1][2].
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- HY-W011560S
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3-Methylflavone-8-carboxylic acid-d5 is the deuterium labeled 3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid[1].
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- HY-B0574S1
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Mefenamic Acid-d3 is the deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
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-
- HY-B0166S6
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L-Ascorbic acid-d2 is the deuterium labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a colla
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- HY-W010452S
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3-Hydroxybutyric acid-d2 (sodium) is the deuterium labeled 3-Hydroxybutyric acid sodium[1]. 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids[2].
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- HY-17556S1
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Folinic acid-d4-1 (Leucovorin-d4-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
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- HY-W008253S1
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5-Hydroxyindole-3-acetic acid-d6 is the deuterium labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
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- HY-W008253S
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5-Hydroxyindole-3-acetic acid-d2 is the deuterium labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
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- HY-Y1718S
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Tridecanoic acid-d2 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation[1].
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- HY-Y1718S1
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Tridecanoic acid-d25 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation[1].
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- HY-Y1718S2
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Tridecanoic acid-d9 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation[1].
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- HY-Y0607S
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4-Nitrobenzoic acid-d4 is the deuterium labeled 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate (Vonoprazan Impurity)[1].
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- HY-I0736S
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Isonicotinic acid-d4 is the deuterium labeled Isonicotinic acid[1]. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C[2].
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- HY-W004260S5
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Arachidic acid-d4-1 is the deuterium labeled Arachidic acid[1]. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[2][3].
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-
- HY-Y1097S
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Monomethyl phthalate-d4 (2-(Methoxycarbonyl)benzoic acid-d4) is the deuterium labeled Monomethyl phthalate. Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule .
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- HY-W041195S
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3-Hydroxy-3-methylhexanoic acid-d5 is the deuterium labeled 3-Hydroxy-3-methylhexanoic acid (HY-W041195). 3-Hydroxy-3-methylhexanoic acid is a fatty acid that is one of the metabolic products of leukocytes .
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- HY-W027544S1
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(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-100807S
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Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2].
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- HY-113067S
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Phytanic acid-d3 is the deuterium labeled Phytanic acid[1]. Phytanic acid is an endogenous metabolite present in Blood that can be used for the research of Zellweger Syndrome, Alpha Methylacyl CoA Racemase Deficiency, Rhizomelic Chondrodysplasia Punctata and Infantile Refsum Disease[2][3][4][5][6].
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- HY-W011819S
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Tetradecanedioic acid-d24 is the deuterium labeled Tetradecanedioic acid[1]. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions[2].
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- HY-W017522S
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Adipic acid-d10 is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].
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-
- HY-W017522S2
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Adipic acid-d4 is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].
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- HY-W017522S4
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Adipic acid-d8 is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].
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- HY-N0067S1
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γ-Aminobutyric acid-d2 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
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- HY-B0574S
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Mefenamic acid-d4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].
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- HY-N0067S
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γ-Aminobutyric acid-d6 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
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- HY-N0830S18
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Palmitic acid-d is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N7057S
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Nonanoic acid-d17 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[1].
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- HY-N7057S1
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Nonanoic acid-d3 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[1].
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-
- HY-N7057S2
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Nonanoic acid-d4 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[1].
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- HY-W017522S5
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Adipic acid-d4-1 is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].
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- HY-121883S
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Lignoceric acid-d47 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].
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- HY-N0830S5
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Palmitic acid-d3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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-
- HY-B1350S
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Fusidic acid-d6 is the deuterium labeled Fusidic acid. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome[1][2].
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- HY-N0830S2
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Palmitic acid-d31 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S4
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Palmitic acid-d2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S7
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Palmitic acid-d4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-121883S3
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Lignoceric acid-d4-11 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].
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- HY-121883S4
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Lignoceric acid-d4-2 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].
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- HY-121883SS5
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Lignoceric acid-d9 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].
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- HY-N0830S14
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Palmitic acid-d17 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S20
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Palmitic acid-d9 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S21
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Palmitic acid-d5 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-W097197S
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(R)-2-((R)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid-d5 is deuterium labeled (R)-2-((R)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid.
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- HY-W168915S
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1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid-d3 is deuterium labeled 1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid.
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- HY-15027S1
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5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].
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- HY-18569S3
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3-Indoleacetic acid-d7 is the deuterium labeled 3-Indoleacetic acid[1]. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.
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- HY-B0398S
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Nalidixic Acid-d5 is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].
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- HY-N0830S11
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Palmitic acid-d2-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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-
- HY-N0830S12
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Palmitic acid-d4-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2][3].
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-
- HY-N0830S13
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Palmitic acid-d4-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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-
- HY-N0830S15
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Palmitic acid-d2-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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-
- HY-N0830S16
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Palmitic acid-d2-3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-N0830S17
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Palmitic acid-d2-4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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-
- HY-N0830S19
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Palmitic acid-d2-5 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
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- HY-W017386S
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3-Methyl-2-oxovaleric acid-d8 (sodium) is the deuterium labeled 3-Methyl-2-oxovaleric acid. 3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids[1].
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- HY-121883S1
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Lignoceric acid-d3 is the deuterium labeled Lignoceric acid[1]. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[2][3].
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-
- HY-N7057S3
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Nonanoic acid-d2 is the deuterium labeled Nonanoic acid[1]. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[2].
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- HY-B1002S
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Oxolinic acid-d5 is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].
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- HY-117275S
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Meclofenamic acid-d4 is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker[1][2][3].
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- HY-W014504S1
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2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid-d7 is the deuterium labeled 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid. 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.
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- HY-N0523S
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Gallic acid-d2 is the deuterium labeled Gallic acid[1]. Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)[2]. Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[3].
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- HY-W008253S2
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5-Hydroxyindole-3-acetic acid-d5is the deuterium labeled5-Hydroxyindole-3-acetic acid(HY-W008253) . 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors .
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- HY-W718300
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Indole-3-pyruvic acid-d5 is deuterated labeled Indole-3-pyruvic acid. Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety .
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- HY-113371S
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2-Methylcitric acid-d3 is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].
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- HY-N0729S1
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Linoleic acid-d11 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2].
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- HY-N0729S
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Linoleic Acid-d4 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2].
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- HY-16322S
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Minodronic acid-d4 is deuterium labeled Minodronic acid. Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].
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- HY-W012946S
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2-Furoic acid-d3 is the deuterium labeled 2-Furoic acid[1]. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation[2]. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats[3].
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- HY-W012974S
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3-Amino-2-methylpropanoic acid-d3 is the deuterium labeled 3-Amino-2-methylpropanoic acid[1]. 3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors[2].
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- HY-N0729S5
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Linoleic Acid-d2 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
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- HY-N0729S4
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Linoleic Acid-d5 is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
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- HY-132334S
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9-cis-Retinoic acid-d5 is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5][6].
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- HY-B0335S
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Tolfenamic acid-d4 is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].
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- HY-14520S
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Tetrahydrofolic acid-d4 is the deuterium labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1][2].
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- HY-W016099S
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3-Methyl-2-quinoxalinecarboxylic acid-d4 is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].
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- HY-146767S
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(3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid-d4 is deuterium labeled (3β,5α,6β)-3,5,6-Trihydroxycholan-24-oic acid.
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- HY-113097S
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3α,7α-Dihydroxycoprostanic acid-d3is the deuterium labeled3α,7α-Dihydroxycoprostanic acid(HY-113097) . 3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α,7α-Dihydroxycoprostanic acid, a bile acid, is the precursor to chenodeoxycholic acid .
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- HY-15027S3
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5-Aminosalicylic acid-d3 disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
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- HY-Y1620S
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3-(3,4-Dimethoxyphenyl)propanoic acid-d10 is the deuterium labeled 3-(3,4-Dimethoxyphenyl)propanoic acid. 3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies and other anemias[1].
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- HY-10585AS1
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Valproic acid-d14 (sodium) is deuterium labeled Valproic acid (sodium). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
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- HY-W013636S1
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2-Ketoglutaric acid-d4 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
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- HY-W013636S2
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2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
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- HY-N1428S6
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Citric acid-d4-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.
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- HY-N0492S
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α-Lipoic Acid-d5 is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].
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- HY-113038AS1
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α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].
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- HY-113410S
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3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].
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- HY-W027544S
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(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3].
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- HY-101981S2
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Uridine 5'-monophosphate-d11 (5'-?Uridylic acid-d11) dilithium is deuterium labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
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- HY-10585AS
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Valproic acid-d7 (sodium) is the deuterium labeled Valproic acid (sodium salt). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
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- HY-N0728S2
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α-Linolenic acid-d14 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
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- HY-10585S3
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Valproic acid-d4 (sodium) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
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- HY-118189S
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Misoprostol acid-d5 is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers[1]. Misoprostol is an oral agent used to induce labor[2].
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- HY-N0728S
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α-Linolenic acid-d5 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
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- HY-Y0682S1
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Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
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- HY-B1899S
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Taurodeoxycholic acid-d5is the deuterium labeledTaurodeoxycholic acid(HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) [5].
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- HY-W009162S2
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Cytidine 5′-monophosphate-d12 (5'-Cytidylic acid-d12 dilithium; 5'-CMP-d12) dilithium is deuterium labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
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- HY-119695AS1
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Simvastatin acid-d9 ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .
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- HY-10585S4
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Valproic acid-d4-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
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- HY-10585S2
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Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
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- HY-10585S
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Valproic acid-d4 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
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- HY-10585S1
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Valproic acid-d6 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
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- HY-A0143S
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Dihomo-γ-linolenic acid-d6 (DGLA-d6) is the deuterium labeled Dihomo-γ-linolenic acid. Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].
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- HY-119695AS
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Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].
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- HY-B0236S1
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6-Aminocaproic acid-d10 is the deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].
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- HY-B0236S
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6-Aminocaproic acid-d6 is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].
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- HY-B1221S
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Flufenamic acid-d4 is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca 2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
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- HY-101329S
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Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].
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- HY-N5134S3
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5'-Guanylic acid-d12 (5'-GMP-d12 dilithium; 5'-guanosine monophosphate-d12) dilithium is deuterium labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
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- HY-14649S2
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11-cis-Retinoic Acid-d5 is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].
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- HY-N2007S
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Veratric acid-d6 is deuterium labeled Veratric acid. Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
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- HY-N0761AS
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trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[3].
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- HY-14649S4
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Retinoic acid-d5 is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha [5].
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- HY-14649S3
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Retinoic acid-d6 is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].
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- HY-W285163S
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1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
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- HY-W751835
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Maximum Cited Publications
21 Publications Verification
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Baloxavir-d4 (Baloxavir acid-d4; S-033447-d4) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d4 (Baloxavir-d4 acid), derived from the proagent Baloxavir-d4 marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d4 inhibits viral RNA transcription and replication and has potently antiviral activity .
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- HY-12765S1
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Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].
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- HY-N0060BS
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(E)-Ferulic acid-d3 is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
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Cat. No. |
Product Name |
Application |
Reactivity |
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- HY-P81667
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Synaptosomal-associated protein 25; SNAP-25; super protein; sup; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP
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WB, ICC/IF, IP
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Human, Mouse, Rat |
Cat. No. |
Product Name |
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Classification |
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- HY-D1327
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Labeling and Fluorescence Imaging
Azide
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Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λex=684 nm, λem=710 nm) [1]sup >. Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-156497
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- HY-50896S1
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CP-358774-<sup>13sup>C6; NSC 718781-<sup>13sup>C6; OSI-774-<sup>13sup>C6
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Alkynes
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Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].
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- HY-12008S1
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CP-358774-<sup>13sup>C6 hydrochloride; NSC 718781-<sup>13sup>C6 hydrochloride; OSI-774-<sup>13sup>C6 hydrochloride
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Alkynes
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Erlotinib- 13C6 (hydrochloride) is the 13C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2]. Erlotinib-13C6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-17413S1
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Azidothymidine-<sup>13sup>C,d3; AZT-<sup>13sup>C,d3; ZDV-<sup>13sup>C,d3
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Azide
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Zidovudine- 13C,d3 is the 13C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Zidovudine-13C,d3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-B0216S2
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17α-Ethynylestradiol-<sup>13sup>C2; Ethynylestradiol-<sup>13sup>C2
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Alkynes
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Ethynyl Estradiol- 13C2 is the 13C-labeled Ethynyl Estradiol. Ethynyl Estradiol-13C2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-14605BS
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AGN1135-<sup>13sup>C3; TVP1012-<sup>13sup>C3 racemic
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Alkynes
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Rasagiline- 13C3 (mesylate racemic) is a 13C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1]. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-W027544S1
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5-(Dimethyl-d6-amino)-N-(prop-2-ynyl)naphthalene-1-sulfonamide
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Alkynes
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(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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